Vaigundaragavendran Jegadeesan

Department of Anesthesia

McGill University, Canada

Email: rags_jeg@yahoo.co.in

Qualifications

2004-2007 Ph.D., Birla Institute of Technology & Science, Medicinal Chemistry and Neuropharmacology

2002-2004 M.S., Birla Institute of Technology & Science, Pharmacy

1998-2002 B.S., Birla Institute of Technology & Science, Pharmacy

Publications (selected)

1. Ragavendran JV, Laferrière A, Xiao WH, Bennett GJ, Padi SS, Zhang J, Coderre TJ, “Topical combinations aimed at treating microvascular dysfunction reduce allodynia in rat models of CRPS-I and neuropathic pain”, J. Pain, 14, 66-78, 2013.
2. Millecamps M, Laferrière A, Ragavendran JV, Stone LS, Coderre TJ, “Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)”, Pain, 151, 174-83, 2010.
3. Jegadeesan Vaigunda Ragavendran, Terence J. Coderre, “Pathophysiological mechanisms and therapeutic drug targets for complex regional pain syndrome – type I”, Int. J. Drug Des. Discov., 1, 1-10, 2010.
4. A. Semwal, P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, J.P. Stables, “Discovery of isatinimino derivatives as new leads for neuropathic pain treatment: an isomeric modification approach”, Int. J. Drug Des. Discov., 1, 169-187, 2010.
5. P. Yogeeswari, J. V. Ragavendran, D. Sriram, A. Priyanka, S. Ganguly, A. Sunil Kumar Reddy, A. Semwal, “Effectiveness of antiepileptic GABA analogues for the treatment of neuropathic pain”, Pharmacologyonline, 1, 575-590, 2010.
6. A. Laferrière, M. Millecamps, D.N. Xanthos, W.H. Xiao, C. Siau, M. de Mos, C. Sachot, J.V. Ragavendran, F.J. Huygen, G.J. Bennett, T.J. Coderre, “Cutaneous tactile allodynia associated with microvascular dysfunction in muscle”, Mol. Pain, 4, 49-59, 2008.
7. J. Vaigunda Ragavendran, D. Sriram, Srikanth Kotapati, James Stables, P. Yogeeswari, “Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach”, Eur. J. Med. Chem., 43, 2650-2655, 2008.
8. P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, R. Kavya, K. Vanitha, N. Harshini, “Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain”, Pharmacol., (Int. J. Exp. Clin. Pharmacol.,) 81, 21-31, 2008.
9. P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, Y. Nageswari, R. Kavya, N. Sreevatsan, K. Vanitha, J.P. Stables, “Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: A hybrid pharmacophore approach”, J. Med. Chem., 50, 2459-2467, 2007.
10. J.V. Ragavendran, I. Vikram Reddy, P. Yogeeswari, D. Sriram, “Synthesis of 4-{[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]amino}-N-substituted phenyl) butanamides possessing antiallodynic and antihyperalgesic activities in two rat models of neuropathic pain”, Med. Chem. Res., 15, 225-226, 2007.
11. P. Yogeeswari, D. Sriram, P. Sahitya, J. Vaigunda Ragavendran, V. Ranganadh, “Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethyl phenylamino)-2-oxoethylamino)-N-(substituted) butanamides-A pharmacophoric hybrid approach”, Bioorg. Med. Chem. Lett., 17, 3712-3715, 2007.
12. P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, “Neuropathic pain: strategies in drug discovery and treatment”, Exp. Opin. Drug Discov., 2, 169-184, 2007.
13. J. V. Ragavendran, D. Sriram, S.K. Patel, I. Vikram Reddy, N. Bharathwajan, J.P. Stables, P. Yogeeswari, “Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore”, Eur. J. Med. Chem., 42, 146-151, 2007.
14. P. Yogeeswari, R. Thirumurugan, D. Sriram, L.R.J. Suniljit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J.P. Stables,  “Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA-mediated mechanism”, Acta Pharm., 56, 259-272, 2006.
15. P. Yogeeswari, D. Sriram, J. Vaigunda Ragavendran, R. Thirumurugan, S. Induja, J.P. Stables, “Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones”, Med. Chem., 2, 55-62, 2006.
16. P. Yogeeswari, J.V. Ragavendran, D. Sriram, “An update on GABA analogs for CNS drug discovery”, Rec. Pat. CNS Drug Discov., 1, 113-118, 2006.
17. P. Yogeeswari, D. Sriram, R. Thirumurugan, J. Vaigunda Ragavendran, K. Sudhan, Roheeth Kumar, J.P. Stables, “Discovery of N-(2,6-dimethylphenyl) substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design”, J. Med. Chem., 48, 6202 – 6211, 2005.
18. P. Yogeeswari, D. Sriram, V. Veena, R. Kavya, K. Rakhra, S. Mehta, J. Vaigunda Ragavendran, R. Thirumurugan, J.P. Stables, “Synthesis of novel aryl semicarbazones as potential anticonvulsant agents”, Biomed. Pharmacother., 59, 51-55,  2005.
19. P. Yogeeswari, D. Sriram, J.V. Ragavendran, R. Thirumurugan, “The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders”, Curr. Drug Metab., 6, 127-139, 2005.
20. P. Yogeeswari, J. Vaigunda Ragavendran, R. Thirumurugan, A. Saxena, D. Sriram, “Ion channels as important targets for antiepileptic drug design”, Curr. Drug Targets, 5, 589-602, 2004.
21. P. Yogeeswari, D. Sriram, V. Saraswat, J. Vaigunda Ragavendran, M. Mohan Kumar, S. Murugesan, R. Thirumurugan, J.P. Stables, “Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides”, Eur. J. Pharm. Sci., 20, 341-346, 2003.