Dr. Wang
Bing
Department of Orthopaedic Surgery and Neurology
University of Pittsburgh School of Medicine, USA
Assistant Professor
Email: bingwang@pitt.edu
Qualifications
1998 Ph.D., Chinese Academy of Sciences
1986 M.D., Huazhong University of Science and
Technology
Publications(selected)
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Christian Isaac, Adam Wright, Arvydas Usas,
Hongshuai Li, Ying Tang, Xiadong Mu, Qing Dong, Nam Vo, James Kang, Bing Wang,
and Johnny Huard. Dystrophin and Utrophin “Double Knockout” Dystrophic Mice
Exhibit a Spectrum of Degenerative Musculoskeletal Abnormalities. Journal of
Orthopaedic Research. 2013; 31: 343-349.
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Sarah A. Beckman, William CW Chen, Ying Tang,
Jonathan Proto, Logan Mlakar, Bing Wang, Johnny Huard. The beneficial effect of
mechanical stimulation on the regenerative potential of MDSCs is lost by
inhibiting VEGF. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013,
(Ahead of Print).
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Xiaodong Mu, Arvydas Usas, Ying Tang, Aiping Lu,
Bing Wang, Kurt Weiss, and Johnny Huard. RhoA mediates defective stem cell
function and heterotopic ossification in dystrophic muscle of mice. The FASEB
Journal • Research Communication. 2013 (Ahead of Print).
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Gao X, Usas A, Lu A, Tang Y, Wang B, Chen C, Li
H, Tebbets JC, Cummins JH, Huard J. BMP2 is superior to BMP4 for promoting
human muscle derived-stem cell mediated bone regeneration in a critical size
calvarial defect model. Cell Transplant. 2012 Nov 1.
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Qing Yang, Ying Tang, Kara Imbrogno, Aiping Lu,
Jonathan D. Proto, Anmin Chen, Fengjin Guo, Freddie H. Fu, Johnny Huard, Bing
Wang. AAV-based shRNA silencing of NF-κB ameliorates muscle pathologies in mdx
mice. Gene Therapy, 2012, 19(12): 1196-204.
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Aiping Lu, Jonathan D Proto, Lulin Guo, Ying
Tang, Mitra Lavasani, Jeremy S Tilstra, Laura J Niedernhofer, Bing Wang, Denis
C Guttridge, Paul D Robbins and Johnny Huard. NF-κB Negatively Impacts the
Myogenic Potential of Muscle-derived Stem Cells. Mol Ther. 2012; 20(3): 661-8.
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Dawn E Bowles, Scott WJ McPhee, Chengwen Li,
Steven J Gray, Jade J Samulski, Angelique S Camp, Juan Li, Bing Wang, Paul E
Monahan, Joseph E Rabinowitz, Joshua C Grieger, Lakshmanan Govindasamy, Mavis
Agbandje-McKenna, Xiao Xiao and R Jude Samulski Phase 1 Gene Therapy for
Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector.Mol
Ther. 2012; 20(2): 443-55.
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Xiang G, Yang Q, Wang B, Sekiya N, Mu X, Tang Y,
Chen CW, Okada M, Cummins J, Gharaibeh B, Huard J. Lentivirus Mediated Wnt11
Gene Transfer Enhances Differentiation of Skeletal Muscle-derived Stem Cells.
Molecular Therapy, 2011, 19(4): 790-796.
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Liqiao Zhou, Tong Zhu, Xiaojing Ye, Lin Yang,
Bing Wang, Xiaoyan Liang, Lina Lu, Yeou-Ping Tsao, Show-Li Chen, Juan Li, and
Xiao Xiao. Long-term protection against HPV E7-positive tumor by a single
vaccination of AAV vectors encoding a fusion protein of inactivated E7 of HPV
16/18 and heat shock protein 70. Human Gene Therapy. 2010, 21: 109-119.
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Ying Tang, Daniel P. Reay, Melessa N. Salay,
Michael Y. Mi, Paula R. Clemens, Denis C. Guttridge, Paul D. Robbins, Johnny
Huard, Bing Wang. Inhibition of the IKK/NF-κB Pathway by AAV Gene Transfer
Improves Muscle Regeneration in Oldermdx Mice. Gene Therapy, 2010, 17 (12),
1476-1483.
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Koppanati BM, Li J, Reay DP, Wang B, Daood M,
Zheng H, Xiao X, Watchko JF, Clemens PR. Improvement of the mdx mouse
dystrophic phenotype by systemic in utero AAV8 delivery of a minidystrophin
gene. Gene Therapy. Gene Therapy, 2010, 17 (11), 1355-1362.
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Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C,
Zheng H, Wang B, Qiao C, Howard JF Jr, Xiao X. Widespread Muscle Expression of
an AAV9 Human Mini-dystrophin Vector After Intravenous Injection in Neonatal
Dystrophin-deficient Dogs.Molecular Therapy. 2010, 18(8): 1501‐1508.
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Bing Wang, Juan Li, Freddie H. Fu, and Xiao
Xiao. Systemic human minidystrophin gene transfer improves functions and
life-span of dystrophin and dystrophin/utrophin deficient mice. Journal of
Orthopaedic Research, 2009, 27: 4, 421-426.
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Michael Y. Mi, Ying Tang, Melessa N. Salay,
Guangheng Li, Johnny Huard, Freddie H. Fu, Christopher Niyibizi, Bing Wang.AAV
based ex vivo gene therapy in rabbit adipose-derived mesenchymal
stem/progenitor cells for osteogenesis. The Open Stem Cell Journal, 2009, 1,
69-75.
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Bing Wang, Juan Li, Chunping Qiao, Chunlian
Chen, Peiqi Hu, Xiaodong Zhu, Liqiao Zhou, Janet Bogan, Joseph Kornegay &
Xiao Xiao. A canine mini-dystrophin is functional and therapeutic in mdx mice.
Gene Therapy, 2008, 15 (15), 1099-1106.
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Bing Wang, Juan Li, Freddie H. Fu, Chunlian
Chen, Xiaodong Zhu, Liqiao Zhou, Xiancheng Jiang, and Xiao Xiao.Construction
and analysis of compact muscle-specific promoters for AAV Vectors. Gene
Therapy, 2008, 15 (22), 1489-1499.
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A. Draviam, Bing Wang, Juan Li, Xiao Xiao &
Simon C Watkins. Mini-dystrophin efficiently incorporates into the dystrophin
protein complex in living cells. Journal of Muscle research and cell motility,
2006, 27(1): 53-67.
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Romesh A. Draviam, Bing Wang, Stuart Shand,
Xiao Xiao & Simon C. Watkins. Alpha-sarcoglycan is recycled from the plasma
membrane in the absence of sarcoglycan complex assembly. Traffic, 2006,
7(7): 793-810.
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Zhong Wang, Tong Zhu, Chunping Qiao, Liqiao
Zhou, Bing Wang, Jiang Zhang, Chunlian Chen, Juan Li, Xiao Xiao.
Adeno-associated Virus Serotype 8 Efficiently Delivers Genes to Muscle and
Heart. Nat Biotechnol. 2005, 23(3): 321-328.
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Bing Wang, Juan Li, Xiao Xiao. Adeno-associated
Virus Vector Carrying Human Minidystrophin Genes Effectively Ameliorates
Muscular Dystrophy in mdx Mouse Model. Proc. Natl. Acad. Sci. USA., 2000,
97(25): 13714-13719.