Department of Diabetes and Metabolic Diseases Research

Beckman Research Institute of the City of Hope

National Medical Center

Email: ssinghal@coh.org

1982  B.Sc., Zoology, Botany, Chemistry, Agra University, India

Publications (selected)

1. Singhal SS, Singhal J, Figarola JL, Horne D, and Awasthi S. (2015) RLIP76 targeted therapy for kidney cancer. Pharm Res (in-press)
2. Singhal SS, Singhal J, Figarola JL, Riggs A, Horne D, and Awasthi S. (2015) 2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention. Biochem Pharmacol (in-press).
3. Figarola JL, Singhal J., Rahbar S., Awasthi S, and Singhal SS. (2014) LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells. Apoptosis 19: 776-788.
4. Figarola JL, Singhal P., Rahbar S., Gugiu BG, Awasthi S, and Singhal SS. (2013) COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. PLoS ONE 8: e83801.
5. Singhal SS, Figarola J, Singhal J, Reddy MA, Liu X, Berz D, Natarajan R, and Awasthi S. (2013) RLIP76 protein knockdown attenuates obesity due to a high-fat diet. J Biol Chem 288: 23394-23406.
6. Singhal SS, Figarola J, Singhal J, Nagaprashantha L, Berz, D., Rahbar S, and Awasthi S. (2013) Novel compound 1, 3-bis (3, 5-dichlorophenyl) urea inhibits lung cancer progression. Biochem Pharmacol 86: 1664-1672.
7. Vatsyayan, R., Singhal, J., Nagaprashantha, L., Awasthi, S., and Singhal SS. (2013) Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma. Mol Carcinogenesis 52: 39-48.
8. Singhal, S.S., Figarola, J., Singhal, J., Leake, K., Nagaprashantha, L., Lincoln, C., Gigiu, G., Horn, D., Jove, R., Awasthi, S., and Rahbar, S. (2012) 1,3-bis(3,5-dichlorophenyl) urea compound ‘COH-SR4’ inhibits proliferation and activates apoptosis in melanoma. Biochem Pharmacol 84: 1419-1427.
9. Lee, S., Wurtzel, J., Singhal, S.S., Awasthi, S., and Goldfinger, L.E. (2012) RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neo-vascularization. Cancer Res 72: 5165-5173.
10. Singhal J, Nagaprashantha L, Vatsyayan R, Ashutosh, Awasthi S, and Singhal SS. (2012) Didymin induces apoptosis by inhibiting N-Myc and up regulating RKIP in neuroblastoma. Cancer Prev Res 5: 473-483.
11. Nagaprashantha, L., Vatsyayan, R., Singhal, J., Lelsani, P., Awasthi, Y.C., Prokai, L., Awasthi, S., and Singhal, SS. (2011) 2-Hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL mutant renal cell carcinoma. Carcinogenesis 32: 568-575.
12. Singhal J, Nagaprashantha, L., Vatsyayan, R., Awasthi S, and Singhal SS. (2011) RLIP76, a glutathione conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. PLoS ONE 6(9): e24688
13. Nagaprashantha LD, Vatsyayan R, Singhal J, Fast, S., Roby, R., Awasthi, S., and Singhal, S.S. (2011) Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Biochem Pharmacol 82: 1100-1109.
14. Singhal, S.S., Wickramarachchi, D., Yadav, S., Singhal, J., Leake, K., Vatsyayan, R., Lelsani, P., Chaudhary, P., Suzuki, S., Suzuki, S., Yang, S., Awasthi, Y.C., and Awasthi, S. (2011) Glutathione-Conjugate Transport by RLIP76 is required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis. Mol Cancer Therapeutics 10: 16-28. (Cover Page Illustration).
15. Awasthi, S., Singhal, S. S., Yadav, S., Singhal, J., Vatsyayan, R., Zajac, E., Luchowski, R., Borvak, J., Gryczynski, K. and Awasthi, Y C. (2010) A central role of RLIP76 in regulation of glycemic control. Diabetes 59: 714-725.
16. Singhal SS, Sehrawat A, Sahu M., Singhal, P., Vatsyayan, R., Lelsani, P., Yadav, S., and Awasthi, S. (2010) RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. In J Cancer 126: 1327-1338.
17. Singhal SS, Yadav S, Singhal J, Sahu M, Awasthi YC and Awasthi S (2009) RLIP76: A target for kidney cancer therapy. Cancer Res 69: 4244-4251.
18. Singhal SS, Yadav S, Singhal J, Sahu M, Sehrawat A and Awasthi S. (2008) Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. FEBS Lett 582: 3408-3414.
19. Singhal, S.S., Yadav, S., Drake, K., Singhal, J. and Awasthi, S. (2008) Hsf-1 and POB1 induce drug-sensitivity and apoptosis by inhibiting Ralbp1. J Biol Chem 283: 19714-19729.
20. Singhal SS, Singhal J, Yadav S, Dwivedi S, Boor P, Awasthi YC and Awasthi S (2007) Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (RALBP1). Cancer Res 67: 4382-4389.
21. Singhal SS, Yadav S, Singhal J, Awasthi YC and Awasthi S (2006) Mitogenic and drug-resistance mediating effects of PKCα require RLIP76. Biochem Biophys Res Commun 348: 722-727.
22. Singhal SS, Awasthi YC and Awasthi S (2006) Regression of Melanoma in a Murine Model by RLIP76 Depletion. Cancer Res 66: 2354-2360.
23. Singhal SS, Yadav S, Singhal J, Drake K, Awasthi YC and Awasthi S (2005) The Role of PKCα and RLIP76 in Transport-mediated Doxorubicin-resistance in Lung Cancer. FEBS Lett 579: 4635-4641.
24. Singhal SS, Yadav S, Singhal J, Zajac E, Drake K, Awasthi YC, and Awasthi S (2005) Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. Biochem Pharmacol 70: 481-488.
25. Awasthi, S., Singhal, S.S., Yadav, S., Singhal, J., Drake, K., Nadkar, A., Zajac, E., Wickramarachchi, D., Rowe, N., Yacoub, A., Boor, P., Dwivedi, S., Dent, P., Jarman, W., John, B. and Awasthi, Y.C. (2005) RALBP1 is a major determinant of radiation sensitivity. Cancer Res 65: 6022-6028.

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Last Updated: 2015-07-08