Prof.
Stephen C. Strom
Department of Laboratory Medicine
Karolinska Institutet, Sweden
Professor
Email: strom@pitt.edu
Qualifications
1978 Ph.D, University of Kansas Medical
Center, Pharmacology
1974 B.A., Westmar College, Biol. &
Chemistry
Publications
(selected)
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Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler
TK, Strom SC, Eaton DL. (2010) Sulforaphane- and phenethyl isothiocyanate-induced
inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of
GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci 116: 422-32.
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Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J,
Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E,
Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY. (2010)
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in
human liver. Genome Res 20: 1020-36.
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Kamagate, AKim, DH Zhang, T, Sluser, S,
Gramignoli, R, Bertera, S, Ringquist, S, Dong, HH (2010) FOXO1 links hepatic
insulin action to endoplasmic reticulum stress. Endocrinology 151: 3521-3535.
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Sharma, S Venkataramanan, R, Caritis, S, Dorko, K,
Strom, SC. (2010) Metabolism of 17α-hydroxyprogesterone caproate by fetal
liver: A new agent for preventing pre-term labor. Drug Metabolism and
Disposition: the biological fate of chemicals 38(5): 723-727.
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Shufeng Liu, Wayne Kuo, Wei Yang, Gregory A.
Gibson, Kenneth Dorko, Simon C. Watkins, Stephen C. Strom, Tianyi Wang. (2010)
The second extracellular loop dictates Occludin-mediates HCV entry. Virology
407(1): 160-170.
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Strom SC, Davila J, Grompe M. 2010. Chimeric mice
with humanized liver: tools for the study of drug metabolism, excretion, and
toxicity. Methods Mol Biol 640: 491-509.
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Soltys KA, Soto-Gutierrez A, Nagaya M, Baskin KM,
Deutsch M, Ito R, Shneider BL, Squires R, Vockley J, Guha C, Roy-Chowdhury J,
Strom SC, Platt JL, Fox IJ. (2010). Barriers to the successful treatment of
liver disease by hepatocyte transplantation. J Hepatol 53: 769-74.
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Kim, DH, Perdomo, G, Zang, T, Slusher, S, Lee, S,
Phillips, YF, Giannoukakis, N, Gramignoli, R., Strom, S, Rinquist, S, Dong, HH.
Fox06 integrates insulin signaling with gluconeogenesis in the liver. Diabetes
60: 2763-2774.
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Singh, R, Bullard, J, Kalra, M, Assefa, S,
Kaul, AK, Vonfeldt, K, Strom, SC, Conrad, RS, Sharp, HL, Kaul, R.
(2011) Status of bacterial colonization, toll-like receptor expression and
nuclear factor-kappaB activation in normal and diseased human livers. Clin.
Immunol. 138: 41-40.
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Ou, Zhimin, Wada, T, Gramignoli, R, Li, S,
Strom, SC, Huang, M, Xie, W. (2011) MicroRNA has-mir-613 targets the human
LXRalpha gene and mediates a feedback loop of LXR autoregulation. Mol.
Endocrinol. 25(4): 584-596.
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Soto-Gutierrez, A, Zhang, L, Medberry, C,
Fukumitsu, K, Faulk, D, Jiang, H, Reing, J, Gramignoli, R, Komori, J,
Ross, M, Herrera, B, Nagaya, M, Lagasse, E, Stolz, D, Strom, SC, Fox,
IJ, Badylak, S. (2011) A whole organ regenerative medicine approach for liver
replacement. Tissue Engineering, Part C Methods.17: 677-686.
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Marongiu, F Gramignoli, R, Dorko, K, Miki,
T, Sharma, S, Tahan, V, Skvorak, KJ, Ellis, E, Davila, J, Laconi, E,
Strom, SC (2011) Hepatic differentiation of human amnion epithelial cells.
Hepatology 53: 1719-1725.
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Meyer zu Schwabedissen, HE, Ware, JA,
Finkelstein, D., Chaudhry, AS, Mansell, S, Leon-Ponte, M, Strom, SC,
Zaher, H, Schwartz, UI, Freeman, DJ, Schuetz, EG, Triona, RG, Kim,
RB. (2011) Hepatic organic anion transporting polypeptide transporter and
thyroid hormone receptor interplay determine cholesterol and glucose
hemostasis. Hepatology 54: 644-654.
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Duncan, AW, Hanlon-Newell, AE, Smith, L, Wilson,
EM, Olson, SB, Thayer, MJ, Strom, SC, Grompe, M. (2012) Frequent aneuploidy
among normal human hepatocytes. Gastroenterology (2012) 142: 25-28.
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Gramignoli, R, Green, M, Tahan, V. Dorko, K,
Skvorak, K, Marongiu, F, Zao, W, Venkataramanan, R, Ellis, ECS, Geller, D,
Breite, A, Dwulet, F, McCarthy, R, Strom, SC. Development and application of
purified tissue dissociation enzyme mixtures for human hepatocyte isolation,
Cell Transplantation (2012) 21: 1245-1260.
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Puppi, J, Strom, SC, Hughes, RD, Bansal, S,
Castell, JV, Dagher, I, Ellis, EC, Nowak, G., Ericzon, B-G , Fox, IJ,
Gómez-Lechón, MJ, Guha, C, Gupta, S, Mitry R, Ohashi, K Ott, M, Reid, M,
Roy-Chowdhury, J, Sokal, E, Weber, A Dhawan, A. (2011) Improving the
Techniques for Human Hepatocyte Transplantation: Report from a Consensus
Meeting in London . Cell Transplantation 21: 1-10.
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Jorns, C, Ellis, EC, Nowak, G, Fischler, B, Nemeth,
A, Strom, SC, Ericzon, BG (2012) Hepatocyte transplantation for inherited
metabolic diseases of the liver. J. Internal Medicine 272: 201-223
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Metukuri, MR, Zhang, P, Basantani, MK, Chin,
C., Stamateters, RE, Alonso, LC, Takane, K, Gramignoli, R, Strom, SC,
O’Doherty, RM, Stewart, AF, Vasavada, RC, Garcia-Ocana, A, Scott, DK.
ChREBP mediates glucose-stimulated pancreatic beta cell proliferation. Diabetes
61: 2004-2015.
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Noreault-Conti, TL, Fellows, A, Jacobs, J, Trask,
H, Strom, SC, Evans, RA, Wrighton, S, Sinclair, P, Sinclair, J, Nichols. R.
(2012) Arsenic decreases RXR±-dependent transcription of CYP3A and suppresses
immune regulators in hepatocytes. Intl. Immunopharmacology 4: 651-656.
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Zang, S, Pillai, VC, Mada, SR, Strom, S,
Venkataramanan, R. (2012) Effects of voriconazole and other azole antifungal
agents on CYP3A activity and metabolism of tacrolimus in human liver
microsomes. Xenobiotica 42: 409-416.
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Skvorak, K, Dorko, K, Marongiu, F, Tahan, V,
Hansel, MC, Gramignoli, R, Gibson, KM, Strom, SC. (2012) Placental stem cell
correction of murine intermediate maple syrup urine disease. Hepatology.
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Hansel, MC, Gramignoli, R, Blake, W, Davila, J,
Skvorak, KJ, Dorko, K, Tahan, V, Brian R. Lee, B, Tafaleng E, Guzman-Lepe, JG,
Soto-Gutierrez, A, Fox, IJ, Strom, SC. Increased reprogramming of human fetal
hepatocytes compared to adult hepatocytes under feeder-free conditions. Cell
Transplantation (In Press).
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Ou, Z, Shi, X, Gilroy, RK, Kirisci, L, Romkes, M,
Lynch, C, Wang, H, Xu, M, Jiang, M, Ren, S, Gramignoli, R, Strom, SC, Huang, M,
Xie, W. (2012) Regulation of human hydroxysteroid sulfotransferase SUL2A1 by
ROR-alpha and ROR-gamma and its potential relevance in human liver diseases.
Molecular Endocrinology (In press).
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Sharma, S, Ellis, EC, Venkataramanan, R, Cretis,
S, Dorko, K, Strom, SC. Hepatobiliary disposition of 17-OHPC and taurocholate
in fetal human hepatocytes: a comparison with adult human hepatocytes. Drug
Metabolism and Disposition (2012) epub, 5 November 2012.
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