Dr. Krishna Balasubramanian

University of Pittsburgh, USA

Email: krb84@pitt.edu

Qualifications

1997  Ph.D., Institute of Microbial Technology, India

1989  M.Sc., Indian Institute of Technology Bombay, India

1987  B.Sc., University of Bombay, India

Publications (selected)

1. Balasubramanian K and Schroit AJ. Membrane lipid asymmetry in ageing and apoptosis. John Wiley & Sons, Inc., Editors, Philippe Devaux and Andreas Herrmann/Transmembrane Dynamics of Lipids, (2012).
2. Kapralov, A, Feng, W. H, Amoscato, A, Yanamala, N, Balasubramanian, K, Winnica, D, Kisin, E, Kotchey, G, Gou, P, Sparvero, L, Klein-Seetharaman, J, Fadeel, B, Star, A, Shvedova, A, Kagan, V. Selective Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration: Role in Uptake by Macrophages. ACS Nano 6 (5) 4147-4156, (2012).
3. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung, MC and Fidler IJ. Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy. Neoplasia 13(3): 286-298, (2011).
4. Fidler IJ, Balasubramanian K, Lin Q, Kim SW, and Kim SJ. The Brain Microenvironment and Cancer Metastasis. Mol. Cells 30, 93-98, (2010).
5. Lin Q, Balasubramanian K, Fan D, Kim SJ, Guo L, Wang Hg, Bar-Eli, M, Aldape KD & Fidler IJ. Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia 12(9): 748-754, (2010).
6. Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A, Prieto VG, Hung MC, Bar-Eli M. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule expression and melanoma metastasis. J Biol. Chem. 284: 28845–28855, (2009).
7. Mirnikjoo B, Balasubramanian K and Schroit AJ. Suicidal Membrane Repair Regulates PS Externalization During Apoptosis. J Biol. Chem. 284: 22512-22516, (2009).
8. Wolfs JL, Comfurius P, Bekers O, Zwaal RF, Balasubramanian K, Schroit AJ, Lindhout T, Bevers EM. Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions. Cell Mol.Life Sci. 66: 314-323, (2009).
9. Mirnikjoo B, Balasubramanian K and Schroit AJ. Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis. J Biol. Chem. 284: 6918-6923, (2009).
10. Maiti SN, Balasubramanian K, Ramoth JA, Schroit AJ. Beta-2-glycoprotein 1-dependent macrophage uptake of apoptotic cells. Binding to lipoprotein receptor-related protein receptor family members. J Biol. Chem. 283: 3761-6, (2008).
11. Sakai T, Balasubramanian K, Maiti S, Halder JB, Schroit AJ. Plasmin-cleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis. Am J Pathol 171: 1659-69, (2007).
12. Balasubramanian K, Mirnikjoo B, Schroit AJ. Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis. J Biol Chem 282: 18357-64, (2007).
13. Balasubramanian K, Maiti SN, Schroit AJ. Recruitment of beta-2-glycoprotein 1 to cell surfaces in extrinsic and intrinsic apoptosis. Apoptosis 10: 439-46, (2005).
14. Bevers EM, Janssen MP, Comfurius P, Balasubramanian K, Schroit AJ, Zwaal RF, Willems GM. Quantitative determination of the binding of beta2-glycoprotein I and prothrombin to phosphatidylserine-exposing blood platelets. Biochem J 386(Pt 2): 271-9, (2005).
15. Balasubramanian K, Schroit AJ. Aminophospholipid Asymmetry: A Matter of Life and Death. Annu.Rev.Physiol 65: 701-734, (2003).