Biography

Magdalene J. Seiler

Department of Anatomy & Neurobiology

Reeve-Irvine Research Center

Sue & Bill Gross Stem Cell Research Center

University of California at Irvine, USA

Project Scientist


Email: mseiler@uci.edu


Qualifications

1985  Ph.D., Ludwig-Maximilians-University, Munich, Germany; Neurochemistry; “Neurotrophic factors in CNS”

1982  Diploma, Ludwig-Maximilians-University, Munich, Germany; Biology


Publications(Selected)

  1. Seiler M. J., Aramant R. B. Cell replacement and visual restoration by retinal sheet transplants (2012). Prog Retin Eye Res, 31, 661-87.
  2. Seiler M. J., Jones B. W., Aramant R. B., Yang P. B., Keirstead H. S., Marc R. E. Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration (2012). Eur J Neurosci, 35, 1692-704.
  3. Harness J. V., Turovets N. A., Seiler M. J., Nistor G., Altun G., Agapova L. S., Ferguson D., Laurent L. C., Loring J. F., Keirstead H. S. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells (2011). PLoS ONE, 6, e14499.
  4. Martinez-Navarrete G., Seiler M. J., Aramant R. B., Fernandez-Sanchez L., Pinilla I., Cuenca N. Retinal degeneration in two lines of transgenic S334ter rats (2011). Exp Eye Res, 92, 227-37.
  5. Nistor G., Seiler M. J., Yan F., Ferguson D., Keirstead H. S. Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells (2010). J Neurosci Methods, 190, 63-70.
  6. Seiler M. J., Aramant R. B., Thomas B. B., Peng Q., Sadda S. R., Keirstead H. S. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets (2010). Eur J Neurosci, 31, 508-20.
  7. Seiler M. J., Rao B., Aramant R. B., Yu L., Wang Q., Kitayama E., Pham S., Yan F., Chen Z., Keirstead H. S. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats (2010). J Neurosci Methods, 188, 250-7.
  8. Seiler M. J., Aramant R. B., Seeliger M. W., Bragadottir R., Mahoney M., Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration (2009). Vet Ophthalmol, 12, 158-69.
  9. Leung K. W., Liu M., Xu X., Seiler M. J., Barnstable C. J., Tombran-Tink J. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors (2008). Invest Ophthalmol Vis Sci, 49, 1221-31.
  10. Radtke N. D., Aramant R. B., Petry H. M., Green P. T., Pidwell D. J., Seiler M. J. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium (2008). Am J Ophthalmol, 146, 172-82.
  11. Seiler M. J., Thomas B. B., Chen Z., Arai S., Chadalavada S., Mahoney M. J., Sadda S. R., Aramant R. B. BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function (2008). Exp Eye Res, 86, 92-104.
  12. Seiler M. J., Thomas B. B., Chen Z., Wu R., Sadda S. R., Aramant R. B. Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons (2008). Eur J Neurosci, 28, 208-20.
  13. Colodetti L., Weiland J. D., Colodetti S., Ray A., Seiler M. J., Hinton D. R., Humayun M. S. Pathology of damaging electrical stimulation in the retina (2007). Exp Eye Res, 85, 23-33.
  14. Peng Q., Thomas B. B., Aramant R. B., Chen Z., Sadda S. R., Seiler M. J. Structure and function of embryonic rat retinal sheet transplants (2007). Curr Eye Res, 32, 781-9.
  15. Qiu G., Seiler M. J., Thomas B. B., Wu K., Radosevich M., Sadda S. R. Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo (2007). Exp Eye Res, 84, 1047-59.
  16. Thomas B. B., Samant D. M., Seiler M. J., Aramant R. B., Sheikholeslami S., Zhang K., Chen Z., Sadda S. R. Behavioral evaluation of visual function of rats using a visual discrimination apparatus (2007). J Neurosci Methods, 162, 84-90.
  17. Thomas B. B., Seiler M. J., Aramant R. B., Samant D., Qiu G., Vyas N., Arai S., Chen Z., Sadda S. R. Visual functional effects of constant blue light in a retinal degenerate rat model (2007). Photochem Photobiol, 83, 759-65.
  18. Thomas B. B., Arai S., Ikai Y., Qiu G., Chen Z., Aramant R. B., Sadda S. R., Seiler M. J. Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats (2006). J Neurosci Methods, 151, 186-93.
  19. Thomas B. B., Aramant R. B., Sadda S. R., Seiler M. J. Retinal transplantation. A treatment strategy for retinal degenerative diseases (2006). Adv Exp Med Biol, 572, 367-76.
  20. Qiu G., Seiler M. J., Mui C., Arai S., Aramant R. B., de Juan E., Jr., Sadda S. Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats (2005). Exp Eye Res, 80, 515-25.
  21. Seiler M. J., Aramant R. B. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function (2005). Semin Ophthalmol, 20, 31-42.
  22. Seiler M. J., Sagdullaev B. T., Woch G., Thomas B. B., Aramant R. B. Transsynaptic virus tracing from host brain to subretinal transplants (2005). Eur J Neurosci, 21, 161-72.
  23. Thomas B. B., Aramant R. B., Sadda S. R., Seiler M. J. Light response differences in the superior colliculus of albino and pigmented rats (2005). Neurosci Lett, 385, 143-7.
  24. Arai S., Thomas B. B., Seiler M. J., Aramant R. B., Qiu G., Mui C., de Juan E., Sadda S. R. Restoration of visual responses following transplantation of intact retinal sheets in rd mice (2004). Exp Eye Res, 79, 331-41.
  25. Aramant R. B., Seiler M. J. Progress in retinal sheet transplantation (2004). Prog Retin Eye Res, 23, 475-94.


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