Dr. Jayadev Raju

Health Canada, Canada

Email: jayadev_raju@hc-sc.gc.ca

Qualifications

1999 Ph.D., Life Sciences, School of Life Sciences, Jawaharlal Nehru University, India

1994 M.Sc., Life Sciences, School of Life Sciences, Jawaharlal Nehru University, India

1992 B.Sc., Zoology, R.K.M. Vivekananda College, University of Madras, India

Publications(Selected)

1. Jayadev Raju, Chandni Sondagar, Jennifer Roberts, Syed Aziz, Don Caldwell, Elizabeth Vavasour, Rekha Mehta. Dietary acrylamide does not augment azoxymethane-induced colon aberrant crypt foci formation in male F344 rats. Food and Chemical Toxicology, 49(6): 1373-1380, 2011
2. Qixuan Chen, Eleonara Swist, Jocelyn Beckstead, Judy Green, Fernando Matias, Jennifer Roberts, Cunye Qiao, Jayadev Raju, Stephen P.J. Brooks and Kylie A. Scoggan. Different doses of dietary oligofructosaccharides and wheat bran elicit different gene expression responses in colon epithelia of healthy Fisher 344 rats. Journal of Nutrition, 141(5): 790–797, 2011
3. Agnieszka Bielecki, Jennifer Roberts, Rekha Mehta, Jayadev Raju. Estrogen receptor-mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones. Nutrition and Cancer, 63(1): 139-150, 2011
4. Sonal Varma, Michael Eskin, Ranjana Bird, Brion Dolenko, Jayadev Raju, Omkar B. Ijare, Tedros Bezabeh. The potential of magnetic resonance spectroscopy (1H MRS) to assess the effect of dietary fatty acids on the progression of inflammatory bowel disease in an animal model. Lipids, 45(9): 843-854, 2010
5. Jayadev Raju, Agnieszka Bielecki, Donald Caldwell, Eric Lok, Marnie Taylor, Kamla Kapal, Ivan Curran, Gerard M. Cooke, Ranjana P. Bird and Rekha Mehta. Soy isoflavones modulate azoxymethane-induced colon carcinogenesis exposed pre- and postnatally and inhibit the growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-b. Journal of Nutrition, 139: 474-481, 2009
6. Jayadev Raju, Rekha Mehta. Cancer chemopreventive and therapeutic properties of diosgenin, a food saponin. Nutrition and Cancer, 61(1): 27-35, 2009
7. Jayadev Raju. AOM-induced rat aberrant crypt foci: Relevance in studying chemoprevention of colon cancer. World Journal of Gastroenterology, 12(23): 6637-6670, 2008
8. Sonal Varma, Ranjana Bird, Michael Eskin, Brion Dolenko, Jayadev Raju, Tedros Bezabeh. Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model. Journal of Inflammation, 4(1): 24, 2007
9. Jayadev Raju and Ranjana P. Bird. Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Letters, 255: 194–204, 2007
10. N.A. Michael Eskin, Jayadev Raju and Ranjana P. Bird. Novel mucilage fraction of Sinapis alba L. (mustard) reduces azoxymethane-induced colonic aberrant crypt foci formation in F344 and Zucker obese rats. Phytomedicine, 14(7-8): 479-485, 2007
11. Jayadev Raju and Ranjana P. Bird. Alleviation of liver steatosis accompanied by modulation of plasma and liver TNF-alevels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. Int. J. Obesity, 30(8): 1298-1307, 2006
12. Jagan M.R. Patlolla, Jayadev Raju, Malisetty V. Swamy and Chinthalapally V. Rao. β-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21 waf1/cip1 in colon cancer cells. Molecular Cancer Therapeutics, 5(6): 1459-1466, 2006
13. Jayadev Raju, Gagan D. Bajaj, Jennifer Chrusch and Ranjana P. Bird. Obese state leads to elevated TGF-and COX isoforms in platelets of Zucker rats.Mol. Cell. Biochem., 284(1-2): 19-24, 2006
14. Jayadev Raju, Malisetty V. Swamy, Indranie Cooma, Jagan M.R. Patlolla, Vernon E. Steele, Bandaru S. Reddy and Chinthalapally V. Rao. Low doses of b-carotene and lutein inhibits AOM-induced rat colonic ACF formation but augments ACF incidence at higher doses. Int. J. Cancer, 113(5): 798-802, 2005
15. Jayadev Raju, Jagan M.R. Patlolla, Malisetty V. Swamy and Chinthalapally V. Rao. Diosgenin, a steroid saponin of Trigonella foenum graecum(fenugreek) inhibit sazoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiology Biomarkers and Prevention, 13(8): 1392-1398, 2004
16. Gacheri A. Kiunga, Jayadev Raju, Natasa Sabljic, Carolyn K. Good, Gagan Bajaj and Ranjana P. Bird. Elevated expression of insulin receptor is a phenotype common to colonic tumors of azoxymethane-injected F344 rats irrespective of dietary lipid interventions. Cancer Letters, 211: 145-153, 2004
17. Jagan M.R. Patlolla, Malisetty V. Swamy, Jayadev Raju and Chinthalapally V. Rao. Overexpression of caveolin-1 in experimental colon carcinogenesis and human colon cancer cell lines. Oncology Reports, 11(5): 957-964, 2004
18. Jayadev Raju and Ranjana P. Bird. Energy restriction reduces the number of advanced ACF and attenuates the expression of colonic TGF-b and COX in Zucker obese (fa/fa) rats. Cancer Research, 63: 6595-6601, 2003
19. Jayadev Raju, Brendan McCarthy, and Ranjana P. Bird. Steady state levels of transforming growth factor-b1 and -b2 mRNA and protein expression are elevated in colonic tumors in vivoirrespective of dietary lipids intervention. Int. J. Cancer, 100(6): 635-641, 2002
20. Jayadev Raju and Ranjana P. Bird. Dietary lipids modulate transforming growth factors and cycloxygenases in the platelet lysates of Male F344 Rats.Mol. Cell. Biochem. 231(1/2): 139-146, 2002