Prof. Douglas Lees Schmucker

University of California, San Francisco, USA

Email: douglas.schmucker@ucsf.edu

Qualifications

1972 Ph.D., Clark University, Biology

Publications(selected)

1. Taylor L. D., A. L. Jones and D. L. Schmucker. 1992. Does aging affect liver microtubules? Proceedings of Society for Experimental Biology and Medicine, 199, 441-445.
2. Schmucker D. L. and E. S. Vesell. 1993. Under-representation of women in clinical drug trials. Clinical Pharmacology and Therapeutics, 54, 11-15.
3. Daniels C. K., P. Perez and D. L. Schmucker. 1993. Alterations in CD8+ cells in gut-associated lymphoid tissues (GALT) of the aging Fischer 344 rat: A correlated immunohistochemical and flow cytometry analysis. Experimental Gerontology, 28, 549-556.
4. Daniels C. K., D. L. Schmucker and B. J. Irvin. 1993. Differential immunoglobulin A responses in the aging Fischer rat following mucosal stimulation with cholera toxin or B subunit. Aging: Immunology & Infectious Disease, 4, 95-107.
5. van Bezooijen R. L., R. K. Wang, M. C. Lechner and D. L. Schmucker. 1994. Aging affects the regulation of preferentially expressed liver proteins in male Fischer 344 rats. Experimental Gerontology 29, 186-196.
6. Wei X., C. Loi, D. L. Schmucker and R. E. Vestal. 1995. Characterization of the independent and combined effects of two inhibitors on oxidative drug metabolism in rat liver microsomes. Biochemical Pharmacology, 49, 1657-1663.
7. Schmucker D. L., J. T. Kato, R. Owen, J. Anderson, C. Miller and M. Heyworth. 1995. Cecal fistula rhesus macaque: a model for gut mucosal immunity. Regional Immunology, 6, 238-242.
8. Vargas J., D. A. Vessey and D. L. Schmucker. 1998. Effect of dehydroepiandrosterone (DHEA) on mucosal immunity in young vs old rats. Experimental Gerontology, 33, 499-505.
9. Schmucker D. L., E. S. Vesell. 1999. Representation of the elderly in clinical drug trials. Journal of Clinical Pharmacy, 39, 1103-1108.
10. Schmucker D. L., 1999. Efficacy of intraduodenal, oral and parenteral boosting in inducing intestinal mucosal immunity to cholera toxin in rats. Immunological Investigations, 28, 339-346.
11. Thoreux K., R. L. Owen and D. L. Schmucker. 2000. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology, 101, 161-167.
12. Thoreux K. and D. L. Schmucker. 2001. Fermented milk enhances intestinal immunity in young, but not in old, rats. Journal of Nutrition, 131, 807-812.
13. Schmucker D. L., K. Thoreux and R. L. Owen. 2001. Aging impairs intestinal immunity. Mechanisms of Aging & Development, 122, 1397-1411.
14. Schmucker D. L. and H. Sachs. 2002. Quantifying dense bodies and lipofuscin as a function of aging: a morphologist’s perspective. Archives of Gerontology & Geriatrics, 34, 249-261.
15. Schmucker D. L., 2002. Intestinal immunosenescence in rats. Experimental Gerontology 37, 197-203.
16. Schmucker D. L., R. L. Owen, R. Outenreath and K. Thoreux. 2003. Basis for the age-related decline in intestinal mucosal immunity Clinical & Developmental Immunology 10. 167-172.
17. Thoreux K., R. L. Owen and D. L. Schmucker. 2007. Functional foods, mucosal immunity and aging:effect of probiotics on intestinal immunity in young and old rats. Communicating Current Research and Educational Topics and Trends in Applied Microbiology, 458-465.
18. Schmucker D. L., K. W. Woodhouse, R. K. Wang, H. Wynne, O. F. James, M. McManus and P. Kremers. 1990. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases. Clinical Pharmacy & Therapeutics, 48, 365-374.
19. Schmucker D. L., C. K. Daniels, R. K. Wang and K. Smith. 1989. Mucosal immune response to cholera toxin in aging rats. I. Antibody and antibody-containing cell response. Immunology, 64, 691-695.
20. Schmucker D. L., R. Gilbert, G. T. Hradek, H. Bazin and A. L. Jones. 1985. Effects of aging on the hepatobiliary transport of immunoglobulin A in the rat. Gastroenterology, 88, 436-443.
21. Schmucker D. L. and R. K. Wang. 1983. Age-dependent alterations in rat liver microsomal NADPH cytochrome c (P-450) reductase: a qualitative and quantitative analysis. Mechanisms of Aging and Development, 21, 137-156.
22. Schmucker D. L., J. S. Mooney and A. L. Jones. 1978. Stereological analysis of hepatic fine structure in the Fischer 344 rat. Influence of sublobular location and animal age. Journal of Cell Biology, 78, 319-337.

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