Dr. Dongmin Liu

Virginia Tech, USA

Email: doliu@vt.edu

Qualifications

2000 Ph.D., Virginia Tech., Nutritional physiol

1992 M.S., Gansu Agricultural University, Animal Genetics

1989 B.S., Gansu Agricultural University, Animal Science

Publications(selected)

1. Gilbert E. R., Liu D., 2012. EPIGENETICS: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics (In press).
2. Si H., Yu J., Jiang H., Lum H., Liu D., 2012. Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells. Endocrinology. 153:3190-8.
3. Pon Velayutham A. B., Liu D., 2012. Epigallocatechin gallate reduces vascular inflammation in db/db mice possibly through a NFκB-mediated mechanism. Molecular Nutrition and Food Research (In press).
4. Zhang Z., Zhen W., Maechler P., Liu D., 2012. Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB. Journal of Nutritional Biochemistry (In press).
5. Pon Velayutham A. B., Si H., Fu Z., Zhen W., Liu D., 2012. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. The Journal of Nutrition. 142:724-30.
6. Fu Z., Gilbert E. R., Pfeiffer L., Zhang Y., Fu Y., Liu D., 2012. Genistein ameliorates hyperglycemia in a mouse model of non-genetic type 2 diabetes. Applied Physiology, Nutrition, and Metabolism. 37:480-8.
7. Wang A., Si H., Liu D., Jiang H. 2012. Butyrate activates the cAMP-protein kinase A-cAMP response element-binding protein signaling pathway in caco-2 cells. The Journal of Nutrition. 142:1-6.
8. Gilbert E., Liu D., 2012. Development of a non-genetic mouse model of type 2 diabetes. Experimental Diabetes Research. 2011:1-12.
9. Zhang Y., Liu D., 2011. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. European Journal of Pharmacology. 670:325-332.
10. Ning Y, Zhen W., Fu Z., Jiang J, Liu D., Belardinelli L, Dhalla AK*, 2011. Ranolazine increases β-cell survival and improves glucose homeostasis in low dose STZ-induced diabetes in mice. Journal of Pharmacology and Experimental Therapeutics 337:50-8.
11. Si H., Fu Z., Jia Z., Zhen W., Pon Velayutham A. B., LeRoith T., Meaney M. P., Voelker K. A., Jia Z., Grange R. W., Liu D., 2011. Dietary cocoa flavonoid epicatechin promotes health and lifespan in obese diabetic mice and Drosophila. The Journal of Nutrition. 141:1095-100.
12. Fu Z., Zhang W., Zhen W., Lum H., Nadler J., Bassaganya-Riera J., Jia Z., Wang Y., Misra H., Liu D., 2010. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 151:3026-3037.
13. Gilbert E., Liu D., 2010. Flavonoids influence epigenetic-modifying enzyme activity: structure-function relationships and the therapeutic potential for cancer. Current Medicinal Chemistry 17:1756-1768.
14. Liu D., O’Leary B., Iruthayanathan M., Love-Homan L., Perez-Hernandez N., Olivo H. F., Dillon J. S., 2010. Evaluation of a novel photoactive and biotinylated dehydroepiandrosterone analog. Molecular and Cellular Endocrinology. 328:56-62.
15. Fu Z., Zhen W., Yuskavage J., Liu D., 2010. Epigallocatechin gallate delays the onset of type I diabetes in spontaneous non-obese diabetic mice. British Journal of Nutrition. 105: 1218–1225.
16. Horacio F. O., Perez-Hernandez N., Liu D., Iruthayanathan M., O’Leary B., Homan L. L., Dillon J. S., 2010. Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA). Bioorganic & Medicinal Chemistry Letters. 20:1153–1155.
17. Guri A.J., Misyak S. A., Hontecillas R., Hasty A., Liu D., Si H., Bassaganya-Riera J., 2010. Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4(+) T cell recruitment into the aortic wall. Journal of Nutritional. Biochemistry. 21:1178-85.
18. Fu Z., Liu D., 2009. Long-term exposure to genistein improves insulin secretory function of pancreatic β-cells. European Journal of Pharmacology. 616:321-327.
19. Si H., Liu D., 2009. Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-α-induced apoptosis through the p38β mitogen-activated protein kinase. Apoptosis. 14:66-76.
20. Liu D., Iruthayanathan M., Homan L. L., Wang Y., Yang Y., Dillon J. S. 2008. Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular regulated kinase 1/2-mediated mechanisms. Endocrinology. 149:889–898 (Editor Editorial, Endocrinology. 2008;149: 886-8).
21. Si H., Liu D., 2008. Genistein increases endothelial nitric oxide synthase expression in human vascular endothelial cells and improves blood pressure in hypertensive rats. The Journal of Nutrition. 138:297-304.
22. Liu D., Si H., Reynolds K. A., Zhen W., Jia Z., Dillon J., 2007. Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Gi-protein-dependent activation of PI-3K/Akt and regulation of antiapoptotic Bcl-2 protein. Endocrinology. 148:3068-76 (Editor Editorial, Endocrinology. 2007;148:3065-7).
23. Anandh Babu P. V., Liu D., 2008. Green tea catechins and cardiovascular health: an update. Current Medicinal Chemistry. 15:1840-50.
24. Si H., Liu D., 2007. Phytochemical genistein in the regulation of vascular function: new insights. Current Medicinal Chemistry. 14:2581-2589.
25. Guri A. J., Hontecillas R., Ferrer J., Casagran O., Wankhade U., Noble A. M., Eizirik D. L., Ortis F., Cnop M., Liu D., Si H., Bassaganya-Riera J., 2007. The loss of PPAR-gamma in immune cells impairs the ability of a natural PPAR-gamma agonist to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. Journal of Nutritional Biochemistry. 19:216-28.

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