Prof. Hsu-Shan Huang

School of Pharmacy and Graduate Institute of Pharmacy

National Defense Medical Center (NDMC), Taiwan

Email: huanghs99@gmail.com

Qualifications

1999-2000 Postdoctoral Fellow, University of Münster, Institute of Pharmaceutical Chemistry (Advisor: Prof. Dr. K. Müller)

1992-1996 Dr. rer. nat., University of Regensburg (Germany), Institute of Pharmaceutical Chemistry

1985-1987 M.S., National Defense Medical Center, Institute of Medicinal Chemistry, Taiwan

1981-1985 B.S., National Defense Medical Center, School of Pharmacy, Taiwan

Publications (Selected)

1. Chen, C. L.;Liu,F. L.;Lee, C. C.; Chen, T. C.;Chang,W. W.; Guh, J. H.; Ali, A.A.A.; Chang, D. M.*;Huang, H. S.* Ring Transformation Strategy for the Synthesis of Anthra[2,3-d]oxazole-2-thione-5,10-dione Homologues as DNA Topoisomerase Inhibitors and as Antitumor Agents, Eur. J. Med. Chem., 2014, submitted.
2. Tang, S. H.; Haung, H. S.;, Wu, H. U.; Tsai, Y. T.; Chuang, M. J.; Chang, S. Y.; Yu, C. P.; Hsiao, P. W.; Sun, G. H.; Yu, D. S.; Cha, T. L.*Emodin Derivative NSC745885 Downregulates EZH2 and Inhibits Cancer Cell Growth, Oncotarget,2014, accepted, in press.
3. Liu, F. C.;Huang, H. S.; Huang, C. Y.; Ro, Y.; Chang, D. M.; Lai, J. H.; Ho, L. J.^*, A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells,Eur. J. Pharmacol.,2014, accepted, in press.
4. Chung, Y. L.; Pan, C. H.; Lioua, W. H.; Sheua, M. J.; Lin, W. H.; Chen, T. C.; Huang, H. S.*; Wu, C. H.* NSC746364, a G-quadruplex stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of ATR/Chk1-dependent pathway, J. Pharmacol. Sci.,2014, 124, 1, 7-17.
5. Lee, C. C.; Chang, D. M.; Huang, K. F.; Chen, C. L.; Chen, T. C.;Lo, Y.; Guh, J. H.*; Huang, H. S.*Design, Synthesis and AntiproliferativeEvaluation of FluorenoneAnalogs with DNA TopoisomeraseI Inhibitory Properties, Bioorg. Med. Chem.,2013, 21, 7125-7133.
6. Chen, T. C.; Yu, D. S.;Huang, K. F.; Fu, Y. C.; Chen, C. L.; Lee, C. C.; Huang, F. C.; Hsieh, H. H.; Lin, J. J.^*; and Huang, H. S.^* Structure-based Design, Synthesis and Biological Evaluation of Novel Anthra[1,2-d]imidazole-6,11-dione Homologues as Potential Antitumor Agent, Eur. J. Med. Chem., 2013,69, 278-293.
7. Liou, W. S.; Hsieh, S. C.; Chang, W. Y.; Wu, H. M. Grace;Huang, H. S.; Lee, C. F.^*Brand name or generic? What Are the Health Professionals Prescribed for Treating Diabetes? A Longitudinal Analysis of the National Health Insurance Reimbursement Database, Pharmacoepidemiol Drug Saf.,2013, 10.1002/pds.3445.
8. Wang, C. H.; Huang, H. S.; Dai, N. T.; Sheu, M. J.; Chang, D. M.^*Ascorbigen Induces Dermal Papilla CellProliferation in Vitro, but Fails toModulateChemotherapy-Induced Alopecia in Vivo, Phytotherapy Research,2013, Mar 11. doi: 10.1002/ptr.4933.
9. Lee, Y. R.;Yu, D. S.; Liang, Y. C.; Huang, K. F.; Chou, S. J.;Chen, T. C.; Lee, C. C.; Chen, C. L.; Chiou, S. H.*;Huang, H. S.*New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cell Lines and Cancer Stem-like Cells caused by Some Selected Anthraquinone-derived Small Molecules, Plos One, 2013, 8(2), e56284.
10. Chen, C. L.; Chang, D. M.;Chen, T. C.;Lee, C. C.;Hsieh, H. H.; Huang, F. C.; Huang, K. F.;Guh, J. H.; Lin, J. J.^*; and Huang, H. S.^* Structure-based Design, Synthesis and Evaluation of Novel Anthra[1,2-d]imidazole-6,11-dione Derivatives as Telomerase Inhibitors and Potential for Cancer Polypharmacology, Eur. J. Med. Chem., 2013,60, 29-41.
11. Lee, C. C.;Huang, K. F.;Chang, D. M.; Hsu, J. J.; Huang, F. C.; Shih, K. N.; Chen, C. L.; Chen, T. C.;Chen, R. H.; Lin, J. J.*; Huang, H. S.*Design, Synthesis and Evaluation of Telomerase Inhibitory, hTERT Repressing, and Anti-proliferation Activities of Symmetrical 1,8-disubstituted Amidoanthraquinones, Eur. J. Med. Chem.,2012, 50, 102-112.
12. Lee, C. C.; Huang, K. F.; Lin, P. Y.;Huang, F. C.;Chen, C. L.; Chen, T. C.; Guh, J. H.; Lin, J. J.*; Huang, H. S.*Synthesis, Antiproliferative Activities and Telomerase Inhibition Evaluation of Novel Asymmetrical 1,2-Disubstituted Amidoanthraquinone Derivatives, Eur. J. Med. Chem.,2012, 47, 323-336.
13. Huang, F. C.; Huang, K. F.; Chen, R. H.; Wu, J. E.; Chen, T. C.; Chen, C. L.; Lee, C. C.; Chen, J. Y.; Lin, J. J.*; Huang, H. S.*Synthesis, Telomerase Evaluation and Anti-proliferative Studies on Various Series of Diaminoanthraquinone-linked Aminoacyl Residues Derivatives, Arch. Pharm., 2012, 345, 101-111.
14. Cheng, C. P.;Huang, H. S.; Hsu, Y. C.; Sheu, M. J.; Chang, D. M.* Benzamide-linked Small Molecule NDMC101 Inhibits NFATc1 and NF-κB Activity: a Potential Osteoclastogenesis Inhibitor for Rheumatoid Arthritis, J. Clin. Immunol.,2012, 32, 762-777.
15. Cheng, M. H.; Yang, Y. C.; Wong, Y. H.; Chen, T. R.; Lee, C. Y.; Yang, C. C.; Chen, S. H.; Yang, I. N.; Yang, Y. S.; Huang, H. S.;Yang, C. Y.; Huang, M. S.;Chiu, H. F.*; B1, A Novel Topoisomerase II Inhibitor, Induces Apoptosis and Cell Cycle G1 Arrest in Lung Adenocarcinoma A549 Cells, Anti-Cancer Drugs,2012, 23(2), 191-199.
16. Chang, Y. L.; Lee, H. J.; Liu, S. T.; Lin, Y. S.; Chen, T. C.; Hsieh, T. Y.*; Huang, H. S.*; Huang, S. M.*, Different roles of p53 in the regulation of DNA damage caused by1,2-heteroannelated anthraquinones and doxorubicin, Int. J. Biochem. Cell Biol., 2011, 43, 1720-1728.
17. Chang, C. J., Hsu, C. C., Chang, C. H., Tsai, L. L., Chang, Y. C., Lu, S. W., Yu, C. H., Huang, H. S.,Wang, J. J., Tsai, C. H., Chou, M. Y., Yu, C. C., Hu, F. W. Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer, Oncol. Rep.2011, Oct; 26(4), 1003-10.
18. Liu, F. C.; Huang, H. S.; Huang, C. Y.; Ro, Y.; Chang, D. M.; Lai, J. H.; Ho, L. J.^*, A benzamide-linked small molecule HS-Cfinhibits TNF-α-induced Interferon Regulatory Factor-1 in porcine chondrocytes: A potential disease-modifying drug for osteoarthritis therapeutics, J. Clin. Immunol.,2011, 31, 6, 1131-1142.
19. Chiang, C. H.; Chang, C. C.; Huang, H. C.; Tsai, P. H.; Jeng, S. Y.; Hung, S. I.; Liang, Y. C.; Huang, H. S.; Chiou, S. H.; Lee, F. Y.; Lee, S. D.; Yuan, C. C.; Hsieh, J. H., Investigation of hepatoprotective activity of induced pluripotent stem cells in the mouse model of liver injury, J. Biomed. Biotechnol.,2011, 2011: 219060.
20. Shchekotikhin, A. E.*; Glazunova, V. A.; Dezhenkova, L. G.; Shevtsova, E. K.; Traven, V. F.;Balzarini, J.;Huang, H. S.;Shtil, A. A.; Preobrazhenskaya, M. N.The first series of 4,11-bis[(2-aminoethyl)amino]anthrax[2,3-B]furan-5,10-diones: synthesis and anti-proliferative characteristics, Eur. J. Med. Chem.,2011, 46(1), 423-428.
21. Huang, H. S.*;Huang, K. F.; Lee, C. C.; Chen, C. L.;Li, C. L.; Lin, J. J.NSC 746364, NSC 746365 and NSC 746366: the spectra of cytotoxicity and molecular correlates of response to telomerase activity, Anti-Cancer Drugs, 2010, 21(2), 169-180.
22. Dutikova, Yu. V.; Borisova, О. F.; Shchyolkina, А. К.; Lin, J. J.; Huang, H. S.; Shtil, А. А.; Kaluzhny, D. N. 5,10,15,20-Tetra-(N-methyl-3-pyridyl)porphyrin destabilizes the anti-parallel telomericquadruplex d(TTAGGG)4, Molecular Biology, 2010, 44, 5, 823-831.
23. Chou, Y. S.; Horng, C. T.; Huang, H. S.; Chen, J. T.; Tsai, M. L. Reactive Arthritis following Streptococcus viridian Urinary Tract Infection, Ocul. Immunol. Inflamm.,2010, 18(1), 41-42.
24. Huang, H. S.*;Chen, J. C.; Chen, R. H.; Huang, K. F.; Huang, F. C.; Jhan, J. R.; Chen, C. L.;Lo, Y.; Lee, C. C.; Lin, J. J.*Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole -6,11-dione homologues, Bioorg. Med. Chem.,2009, 17, 7418-7428.
25. Shchekotikhin, A. E.*; Glazunova, V. A.; Dezhenkova, L. G.; Luzikov, Y. N.; Sinkevich, Y. B.; Kovalenko, L. V.; Buyanov, V. N.; Balzarini, J.; Huang, F. C.; Lin, J. J.; Huang, H. S.; Shtil, A. A.;Preobrazhenskaya, M. N. Synthesis and cytotoxic properties of 4,11-bis [(aminoethyl)amino]anthra-[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones, Bioorg. Med. Chem.,2009, 17, 1861-1869.