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Prof. Guoan Chen

The University of Michigan, USA

Email: guoanche@umich.edu


1996 Ph.D., Peking Union Medical College, Oncology

1988 M.Sc., Xi’an Jiaotong University, Pulmonary Medicine

1981 M.D., Xi’an Jiaotong University, Medicine

Publications (selected)

  1. Mahaveer S. Bhojani*, Guoan Chen*, Brian D. Ross, David G. Beer,AlnawazRehemtulla. Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. Cell Cycle. 2005 Nov;4(11):1478-81. Epub 2005 Nov 20. (* co-authors).
  2. Mitch Raponi, Yi Zhang, Jack Yu, Guoan Chen, Grace Lee, Jeremy M.G. Taylor, James MacDonald, Dafydd Thomas, Christopher Moskaluk, Yixin Wang and David G. Beer. Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung. Cancer Res. 66(15):7466-72, 2006.
  3. Guoan Chen, Xiaoju Wang, Jianjun Yu, SooryanarayanaVarambally, Jindan Yu, Dafydd G. Thomas, Mu-Yen Lin, Prakash Vishnu, Zhuwen Wang, Rui Wang, Jeff Fielhauer, DebashisGhosh, Thomas J. Giordano, Donald Giacherio, Andrew C. Chang, Mark B. Orringer, Talal El-Hefnawy, William L. Bigbee, David G. Beer and Arul M. Chinnaiyan. Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma.Cancer Res.67(7):3461-7,2007.
  4. Jindan Yu, Qi Cao, RohitMehra, BharathiLaxman, Jianjun Yu, Scott A. Tomlins, Chad J. Creighton, Saravana M. Dhanasekaran, RonglaiShen, Guoan Chen, David S. Morris, Victor E. Marquez, Rajal B. Shah, DebashisGhosh, SooryanarayanaVarambally and Arul M. Chinnaiyan Integrative Genomics Analysis Reveals Silencing of β-Adrenergic Signaling by Polycomb in Prostate Cancer. Cancer Cell. 12(5):405-7,2007.
  5. Jindan Yu, Jianjun Yu, Daniel R. Rhodes, Scott A. Tomlins, Xuhong Cao, Guoan Chen, RohitMehra, Xiaoju Wang, DebashisGhosh, Rajal B. Shah, SooryanarayanaVarambally, Kenneth J. Pienta and Arul M. Chinnaiyan A Polycomb Repression Signature in Metastatic Prostate Cancer Predicts Cancer Outcome. Cancer Res. 67(22):10657-63,2007.
  6. Shuanying Yang, Yandong Nan, Yingxuan Tian, Wei Zhang, Bin Zhou, Lina Bu, Shufen Huo, Guoan Chen, Jiekai Yu and Shu Zheng. Study of distinct protein profiles for early diagnosis of NSCLC using LCM and SELDI-TOF-MS. Medical Oncology. 2008 Feb 26. [Epub ahead of print].
  7. Daniel Albertus*, Christopher W. Seder*, Guoan Chen*, XiaojuWang*,WibisonoHartojo, Lin Lin, Amy Silvers, Daffyd G. Thomas, Thomas J. Giordano, Andrew C. Chang, Mark B. Orringer, William L. Bigbee, Arul M. Chinnaiyan, and David G. Beer. AZGP1 Autoantibody Predicts Survival AND Histone Deacetase Inhibitors Increase Expression in in Lung Adenocarcinoma. J. of Thoracic Oncology. 2008 Nov;3(11):1236-44.(* co-authors).
  8. Seder CW, Hartojo W, Lin L, Silvers AL, Wang Z, Thomas DG, Giordano TJ, Chen G, Chang AC, Orringer MB, Beer DG. INHBA Overexpression Promotes Cell Proliferation and May Be Epigenetically Regulated in Esophageal Adenocarcinoma. J ThoracOncol. 2009 Apr;4(4):455-62.
  9. Seder CW, Hartojo W, Lin L, Silvers AL, Wang Z, Thomas DG, Giordano TJ, Chen G, Chang AC, Orringer MB, Beer DG. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia. 2009 Apr;11(4):388-96.
  10. Mitch Raponi,Lesley Dossey, Tim Jatkoe, Xiaoying Wu, Guoan Chen, Hongtao Fan & David G. Beer. MicroRNA Classifiers for Predicting Prognosis of Squamous Cell Lung Cancer. Cancer Research. 2009 Jul;69(14):5776-83.
  11. Khaled A. Hassan *, Guoan Chen *, Gregory P. Kalemkerian, Max Wicha, David G. Beer. An embryonic stem cell–like signature identifies poorly-differentiated lung adeno but not squamous carcinoma. Clin Cancer Res. 2009 Oct 15;15(20):6386-90. Epub 2009 Oct 6. (* co-authors).
  12. Xiao-Song Wang, John R. Prensner, Guoan Chen, Qi Cao, Bo Han, Saravana M Dhanasekaran, RakeshPonnala, Xuhong Cao, SooryanarayanaVarambally, Dafydd G. Thomas, Thomas J. Giordano, David G. Beer, Nallasivam Palanisamy, Maureen A. Sartor, Gilbert S. Omenn, Arul M. Chinnaiyan. Integrative Analyses Reveal the Functional and Genetic Associations of Gene Fusions in Cancer. Nat Biotechnol. 2009 Nov;27(11):1005-11. Epub 2009 Nov 1.
  13. Silvers AL, Lin L, Bass AJ, Chen G, Wang Z, Thomas DG, Lin J, Giordano TJ, Orringer MB, Beer DG, Chang AC.Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.Clin Cancer Res. 2010 Apr 1;16(7):2009-21. Epub 2010 Mar 23.
  14. Bryant CM, Albertus DL, Kim S, Chen G, Brambilla C, Guedj M, Arima C, Travis WD, Yatabe Y, Takahashi T, Brambilla E, Beer DG.Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study. PLoS One. 2010 Jul 22; 5(7):e11712.
  15. Chen G, Kim SH, King AN, Zhao L, Simpson RU, Christensen PJ, Wang Z, Thomas DG, Giordano TJ, Lin L, Brenner DE, Beer DG, Ramnath N. CYP24A1 Is an Independent Prognostic Marker of Survival in Patients with Lung Adenocarcinoma. Clin Cancer Res. 2010 Dec 17. [Epub ahead of print].
  16. Meng H*,Chen G*, Zhang X, Wang Z, Thomas DG, Giordano TJ, Beer DG, Wang MM. Stromal LRP1 in Lung Adenocarcinoma Predicts Clinical Outcome. Clin Cancer Res. 2011 Apr 15;17(8):2426-33. Epub 2011 Feb 15.(* co-authors).
  17. Ray D, Ahsan A, Helman A, Chen G, Hegde A, Gurjar SR, Zhao L, Kiyokawa H, Beer DG, Lawrence TS, Nyati MK. Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.Neoplasia. 2011 Jul;13(7):570-8. PMID: 21750651.
  18. Gong HC, Wang S, Mayer G, Chen G, Leesman G, Singh S, and Beer DG. Signatures of Drug Sensitivity in Nonsmall Cell Lung Cancer. International Journal of Proteomics, Volume 2011 (2011), Article ID 215496.
  19. Chen G, Kim S, Taylor JM, Wang Z, Lee O, Ramnath N, Reddy RM, Lin J, Chang AC, Orringer MB, Beer DG. Development and validation of a quantitative real-time polymerase chain reaction classifier for lung cancer prognosis. J ThoracOncol. 2011 Sep; 6(9):1481-7. PMID: 21792073.
  20. Chen G, Beer DG. Response to translating cancer complexity to clinical decisions.  J ThoracOncol. 2011 Sep;6(9):1456-7. PMID: 21849851.