Dr. Daniel Sliva
Cancer
Research Laboratory
Methodist
Research Institute
Indiana
University Health
Indianapolis,
Indiana, USA
Department
of Medicine
Indiana
University School of Medicine
Indianapolis,
Indiana, USA
Email:
dsliva@iuhealth.org
Qualifications
1993
Ph.D., Charles University, Molecular Biology and Genetics
1988
M.Sc., Charles University, Biochemistry
1983
M.Sc.,University of Chemical Technology, Food and Biochemical Technology
Publications
(Selected)
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Jiang
J, Eliaz I, Sliva D. Synergistic effect of the modified citrus pectin
Pectasol-CTM with BreastDefendTM and ProstaCaidTM in the suppression of
invasive behavior of human breast and prostate cancer cells. Integr Cancer
Ther. 2012 Apr 24. [Epub ahead of print]
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Jiang
J, Thyagarajan-Sahu A, Krchňák V, Jedinak A, Sandusky GE, Sliva D. NAHA, a
Novel Hydroxamic Acid-Derivative, Inhibits Growth and Angiogenesis of Breast
Cancer In Vitro and In Vivo. PLoS One. 2012;7(3):e34283. Epub 2012 Mar 29.
-
Jiang
J, Loganathan J, Eliaz I, Terry C, Sandusky G, Sliva D. ProstaCaidTM inhibits
tumor growth in a xenograft model of human prostate cancer. Int J Oncol. 2012;
40: 1339-44.
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Jiang
J, Slivova V, Jedinak A, Sliva D. Gossypol inhibits growth, invasiveness, and
angiogenesis in human prostate cancer cells by modulating NF-kB/ AP-1
dependent- and independent- signaling. Clin Exp Metastasis. 2012; 29: 165-78.
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Kennedy
EM, P'pool SJ, Jiang J, Sliva D, Minto RE. Semisynthesis and biological
evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod.
2011; 74: 2332-7.
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Jiang
J, Jedinak A, Sliva D. Ganodermanontriol (GDNT) exerts its effect on growth and
invasiveness of breast cancer cells through the down-regulation of CDC20 and
uPA. Biochem Biophys Res Commun. 2011; 415: 325-9.
-
Sliva
D. Medicinal mushroom Phellinus linteus as an alternative cancer therapy
(Review). Exp Ther Medicine 2010; 1: 407-411.
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Harvey
K. A., Welch Z., Sliva D., Siddiqui R. A., Role of Rho kinase in sphingosine
1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation.
Mol. Cell Biochem., 2010; 342: 7-19.
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Jedinak
A, Dudhgaonkar S, Sliva D. Activated macrophages induce metastatic behavior of
colon cancer cells. Immunobiology. 2010; 215: 242-9.
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Sliva
D. Medicinal potential of Ganoderma lucidum. In: Applied Mycology, (CAB
International, Eds.: M. Rai and P.D. Bridge), 2009, pp 173-196.
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Adamec
J, Jannash A, Dudhgaonkar S, Jedinak A, Sedlak M, Sliva D. Development of a new
method for improved identification and relative quantification of unknown
metabolites in complex samples: Determination of a triterpenoid metabolic
fingerprint for the in situ characterization of Ganoderma bioactive compounds.
J Separation Sci. 2009; 32: 4052-8.
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Jiang
J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and
invasive behavior of breast cancer cells by modulating AP-1 and NF-B signaling.
Int J Mol Med. 2008;21:577-84.
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Sliva
D, and Srivastvava R: Regulation of NF-B function: target for drug
development. In: Molecular Mechanisms Volume 1: Apoptosis, Cell Signaling, and
Human Disease, (The Humana Press, Inc., Ed.: Srivastava R.), 2007, pp 239-261.
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Jiang
J, Slivova V, Sliva D. Ganoderma lucidum inhibits proliferation of human breast
cancer cells by down-regulation of estrogen receptor and NF-B signaling. Int J
Oncol. 2006;29:695-703.
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Sliva
D. Ganoderma lucidum in cancer research. Leukemia Res. 2006; 30: 767-8.
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Slivova
V, Zaloga G, DeMichele SJ, Mukerji P, Huang YS, Siddiqui R, Harvey K,
Valachovicova T, Sliva D. Green tea polyphenols modulate secretion of urokinase
plasminogen activator (uPA) and inhibit invasive behavior of breast cancer
cells. Nutr Cancer. 2005; 52: 65-72.
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Stanley
G, Harvey K, Slivova V, Jiang J, Sliva D. Ganoderma lucidum suppresses
angiogenesis through the inhibition of secretion of VEGF and TGF from prostate
cancer cells. Biochem Biophys Res Commun. 2005; 330: 46-52.
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Sliva
D. Soy isoflavones and the invasiveness of breast cancer. AgroFOOD industry
hi-tech. 2005; 16: 40-1.
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Valachovicova
T, Slivova V, Bergman H, Shuherk J, Sliva D. Soy isoflavones suppress
invasiveness of breast cancer cells by the inhibition of NF-B/AP-1 -dependent
and -independent pathways. Int J Oncol. 2004; 25: 1389-96.
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Jiang
J, Slivova V, Harvey K, Valachovicova T, Sliva D. Ganoderma lucidum suppresses
growth of breast cancer cells through the inhibition of Akt/NF-B signaling.
Nutr Cancer 2004; 49: 209-16.