Dr. Kambiz N. Alavian

School of Medicine

Section of Endocrinology and Metabolism

Department of Internal Medicine

Yale University, USA

Associate Research Scientist

Email: kambiz.alavian@yale.edu

Qualifications

2003-2006 Ph.D., University of Heidelberg, Neuroscience

2002-2003 M.S., Illinois Institute of Technology, Biology

1999-2001 B.S., University of Illinois at Chicago, Biology

Publications (selected)

1. Thuret, S., Alavian, K.N., Gassmann, M., Lloyd, C.K., Smits, S.M., Smidt, M.P., Klein, R., Dyck, R.H. and Simon, H.H., The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem, 2004. 91(6): p. 1302-1311.
2. Sgado, P., Alberi, L., Gherbassi, D., Galasso, S.L., Ramakers, G.M., Alavian, K.N., Smidt, M.P., Dyck, R.H. and Simon, H.H., Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A, 2006. 103(41): p. 15242-15247.
3. Alavian, K.N., Scholz, C. and Simon, H.H., Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord, 2008. 23(3): p. 319-328. (review)
4. Alavian, K.N., Sgado, P., Alberi, L., Subramaniam, S., and Simon, H.H., Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev, 2009. 4: p. 11.
5. Alavian, K.N. and Simon, H.H., Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database. Mol Neurodegener, 2009. 4: p. 6.
6. Pruszak, J., Ludwig, W., Blak, A., Alavian, K. and Isacson, O., CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells, 2009. 27(12): p. 2928-2940.
7. Simon, H.H. and Alavian, K.N., Transcriptional regulation of their survival: the Engrailed homeobox genes. Adv Exp Med Biol, 2009. 651: p. 66-72. (book chapter)
8. Chung, C.Y., Licznerski, P., Alavian, K.N., Simeone, A., Lin, Z., Martin, E., Vance, J. and Isacson, O., The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain, 2010. 133:2022-2031.
9. Sanchez, C.E., Tierney, T.S., Gale, J.T., Alavian, K.N., Sahin, A., Lee, J.S., Mulligan, R.C. and Carter, B.S., Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg, 2010. 114(3): p. 672-680.
10. Vahedi, S., Rajabian, M., Misaghian, A., Grbec, D., Simon, H.H. and Alavian, K.N., Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. J Biomed Sci, 2010. 17: p. 66.
11. Alavian, K.N., Li, H., Collis, L., Bonanni, L., Zeng, L., Sacchetti, S., Lazrove, E., Nabili, P., Flaherty, B., Graham, M., Chen, Y., Messerli, S.M., Mariggio, M.A., Rahner, C., McNay, E., Shore, G.C., Smith, P.J., Hardwick, J.M. and Jonas, E.A., Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase. Nature Cell Biol, 2011. 13(10): p. 1224-1233.
12. Chen, Y.B., Aon, M.A., Hsu, Y.T., Soane, L., Teng, X., McCaffery, J.M., Cheng, W.C., Qi, B., Li, H., Alavian, K.N., Dayhoff-Brannigan, M., Zou, S., Pineda, F.J., O'Rourke, B., Ko, Y.H., Pedersen, P.L., Kaczmarek, L.K., Jonas, E.A. and Hardwick, J.M., Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal of Cell Biology, 2011. 195(2), 263-276.
13. Ofengeim, D., Chen, Y.-B., Miyawaki T, Li, H., Sacchetti, S., Flannery, R., Alavian, K.N., Pontarelli, F., Hickman, J.A., Hardwick, J.M.,  Zukin, R.S. and Jonas, E.A., N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neuroscience, 2012. 10.1038/nn.3054.
14. Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Mangold, J., Signore, A., DeMarco, U., Damady, D., Smith, P.J.S., Gribkoff, V.K. and Jonas, E.A., Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Research, 2012. 10.1016/j.brainres.2012.01.046.
15. Gray, J.P., Alavian, K.N., Jonas, E.A. and Heart, E.A. (2012). NAD kinase (NADK) regulates the size of NADPH pool and insulin secretion in pancreatic beta cells. Am J Physiol Endocrinol Metab. 2012. doi:10.1152/ajpendo.00465.2011.
16. Li, H., Alavian, K.N., Lazrove, E., Mehta, N., Jones, A., Zhang, P., Licznerski, P., Graham, M., Uo, T., Duman, R.S., Morrison, R.S., Rahner, C. and Jonas, E.A., A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Under revision, Nature Cell Biology.
17. Alavian, K.N., Lazrove, E., Nabili, P., Li, H. and Jonas, E.A., A non-selective ion channel within the C-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Submitted to Nature.
18. Licznerski, P., Duric, V., Banasr, M., Alavian, K.N., Jonas, E.A. and Duman, R.S., Serum and glucocorticoid-induced Kinase- (SGK) in post-traumatic stress disorder and depression. Under revision for Science.
19. Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Li, H., Mangold, J., Signore, A., DeMarco, U., Damady, D., Smith, P.J.S., Gribkoff, V.K., Jonas, E.A. Dexpramipexole (KNS-760704) inhibits stress-induced mitochondrial membrane conductance and improves cellular bioenergetic efficiency. Under revision.
20. Alavian, K.N., Lazrove, E. and Jonas E.A. DJ1 regulates neuronal metabolic efficiency through modulation of the mitochondrial inner membrane potional. In preparation.
21. Jonas. E.A., Chatterjee, G., Zhang, P., Alavian, K.N., Carrithers, L.M. and Carrithers, M.D., Electrophysiological Characterization of an Endosomal Macrophage Splice Variant of the Human SCN5A Sodium Channel. In preparation.
22. Alavian, K.N., Tierney T.S., Pruszak, J., Ludwig, W., Hargus, G., Astradsson, A. and Isacson, O. P53-mediated cell cycle arrest prevents tumorigenesis in human embryonic stem cell-derived dopaminergic grafts. In preparation.

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