Prof. Ben Chung-Lap Chan

Chinese University of Hong Kong, Hong Kong, China

Email: benchan99@cuhk.edu.hk

Qualifications

2004 Ph.D., Chinese University of Hong Kong, Pharmacology

1999 M.Sc., City University of Hong Kong, Computing

1995 B.Sc., Hong Kong Baptist University, Applied Biology

Publications(Selected)

1. Chan BC., Lau CB, Jolivalt C, Lui SL, Ganem-Elbaz C, Paris C, Litaudon M, Fung KP, Leung PC and Ip M (2011) Chinese Medicinal Herbs Against Antibiotic resistant Bacterial Pathogen. Mendez-Vilas A. (Ed.), Microbiology Book Series – 2011 Edition, Science against microbial pathogens: communicating current research and technological advances. Badajoz, Formatex Research Center.
2. http://www.formatex.org/microbiology3/about.html
3. Chan BC, Ip M., Lau CB, Han QB, Jolivalt C, Paris J, Reiner NE, See RH, Fung KP, Leung PC(2012) Medicinal herbs against methicillin-resistant Staphylococcus aureus (MRSA) infections - Mechanism of actions. Singh V. K., Govil J. N. (eds.) Recent Progress in Medicinal Plants Vol. 32 Texas, Global Media
4. Han XQ, Chan BC, Yu H, Yang YH, Hu SQ, Ko CH, Dong CX, Wong CK, Shaw PC, Fung KP, Leung PC, Hsiao WL, Tu PF, Han QB. Structural characterization and immuno-modulating activities of a polysaccharide from Ganoderma sinense. Int J Biol Macromol. 2012 51:597-603.
5. Han XQ, Chan BC, Dong CX, Yang YH, Ko CH, Gar-Lee Yue G, Chen D, Wong CK, Bik-San Lau C, Tu PF, Shaw PC, Fung KP, Leung PC, Hsiao WL, Han QB. Isolation, structure characterization, and immunomodulating activity of a hyperbranched polysaccharide from the fruiting bodies of Ganoderma sinense. J Agric Food Chem. 2012 60:4276-81.
6. Yue GG, Kin-Ming Lee J, Cheng L, Chan BC, Jiang L, Fung KP, Leung PC, Bik-San Lau C. Reversal of P-glycoprotein-mediated multidrug resistance in human hepatoma cells by hedyotiscone A, a compound isolated from Hedyotis corymbosa. Xenobiotica. 2012 42:562-70.
7. Chan BC, Yu H, Wong CW, Lui SL, Jolivalt C, Ganem-Elbaz C, Paris JM, Morleo B, Litaudon M, Lau CB, Ip M, Fung KP, Leung PC, Han QB. Quick identification of kuraridin, a noncytotoxic anti-MRSA (methicillin-resistant Staphylococcus aureus) agent from Sophora flavescens using high-speed counter-current chromatography. J Chromatogr B 2012 880:157-62.
8. Yue GG, Chan BC, Kwok HF, To MH, Hon KL, Fung KP, Lau CB, Leung PC. Screening for Anti-inflammatory and Bronchorelaxant Activities of 12 Commonly Used Chinese Herbal Medicines. Phytother Res. 2012 26:915-25.
9. Hon KL, Chan BC, Leung PC. Chinese herbal medicine research in eczema treatment. Chin Med. 2011 6:17.
10. Chan BC, Ip M, Lau CB, Lui SL, Jolivalt C, Ganem-Elbaz C, Litaudon M, Reiner NE, Gong H, See RH, Fung KP, Leung PC. Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase. J Ethnopharmacol. 2011 137:767-73.
11. Yue GG, Chan BC, Hon PM, Lee MY, Fung KP, Leung PC, Lau CB. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 48:2011-20.
12. Yue GG, Chan BC, Hon PM, Kennelly EJ, Yeung SK, Cassileth BR, Fung KP, Leung PC, Lau CB. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int J Biol Macromol. 2010 47:342-7.
13. Chan BC, Hon KL, Leung PC, Sam SW, Fung KP, Lee MY, Lau HY. Traditional Chinese medicine for atopic eczema: PentaHerbs formula suppresses inflammatory mediators release from mast cells. J Ethnopharmacol. 2008 120:85-91.
14. Chan BC, Ching AK, To KF, Leung JC, Chen S, Li Q, Lai PB, Tang NL, Shaw PC, Chan JY, James AE, Lai KN, Lim PL, Lee KK, Chui YL. BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma. Oncogene. 2008 27:1208-17.
15. Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL. BRE enhances in vivo growth of tumor cells. Biochem Biophys Res Commun. 2005 J326:268-73.
16. Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem. 2004 279:52106-16.
17. Chan BC, To KF, Pang JC, Chung YF, Lo KW, Tong JH, Huang DW, Lim PL, Chui YL. Generation of monoclonal antibodies against Hong Kong nasopharyngeal carcinoma-associated Epstein-Barr virus latent membrane protein 1 (LMP1). Int J Cancer. 2002 102:492-8.
18. Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL. Expression of human BRE in multiple isoforms. Biochem Biophys Res Commun. 2001 288:535-45.
19. Lau HY, Chan CL. Modulation of intracellular cyclic AMP in immunologically activated rat peritoneal mast cells by prostaglandin D2. Inflamm Res. 2001 50 Suppl 2:S61-2.
20. Chan CL, Jones RL, Lau HY. Characterization of prostanoid receptors mediating inhibition of histamine release from anti-IgE-activated rat peritoneal mast cells. Br J Pharmacol. 2000 129(3):589-97.
21. Chan CL, Lau HY. Prostanoid DP receptor activation inhibits anti-IgE induced histamine release from rat peritoneal mast cells. Inflamm Res. 1999 48 Suppl 1:S29-30.
22. Chan CL, Lau HY. Effects of prostanoid receptor agonists on immunologically-activated rat peritoneal mast cells. Inflamm Res. 1998; 47.