Prof. Gee A. Lau
Department of Pathobiology
University of Illinois at Urbana-Champaign, USA
Associate Professor
Email: geelau@illinois.edu
Qualifications
1992 Ph.D., Purdue University, USA
1990 M.Sc., University
of Wisconsin-Madison, USA
1988 B.Sc., University
of Wisconsin-Madison, USA
Publications (Selected)
-
Rahme L, Ausubel F, Cao H, Drenkard E,
Goumneov B, Lau GW, Plotnikova J, Tompkins R, Tsongalis J, Walendziewicz C.
2000. Plants and animals share functionally common bacterial virulence factors. PNAS97:
8815-8821.
-
Lau GW, S Haataja, M Lonetto, S
Kensit, A Mara, D Holden. 2001. A functional genomics of type III Streptococcus
pneumoniae virulence. Mol Microbiol40: 555-571.
-
Baldini R, Lau GW, Rahme L. 2002. The
use of plant and insect hosts to model bacterial pathogenesis. Methods
Enzymol 358: 3-13.
-
Ran H, Hassett DJ, Lau GW. 2003. Human
Targets of Pseudomonas aeruginosa pyocyanin. PNAS100:
14315-14320 (Track II).
-
Potvin E, Lehoux D, Kukavica-Ibrujl I,
Richard K, Sanschagrin F, Lau GW, Levesque RC. 2003. In vivo functional
genomics of Pseudomonas aeruginosafor high throughput screening of
novel virulence factors and antibacterial targets. Environ Microbiol 5:
1294-1308.
-
Lau GW, Ran H, Kong FS, Hassett DJ,
Mavrodi D. 2004. Pseudomonas aeruginosa pyocyanin is critical for
lung infection in mice. Infect Immun 72: 4275-4278.
-
Lau GW, Ran H, Hassett DJ, Kong FS.
2004. The role of pyocyanin in Pseudomonas aeruginosa infection. Trends
Mol Med 10: 599-606.
-
Lau GW, Britigan BE, Hassett DJ. 2005. Pseudomonas
aeruginosa OxyR is required for full virulence in rodent and insect models
of infection and for resistance to human neutrophils. Infect Immun73: 2550-2553.
-
Apidianakis Y, Mindrinos M, Xiao W,
Lau GW, Baldini R, Davis RW, Rahme LG. 2005. Profiling early host response to
infection: Pseudomonas aeruginosapotentiates disease by restricting
antimicrbial peptide gene expression. PNAS102: 2573-2578.
-
Lau GW, Hassett DJ, Britigan BE. 2005.
Modulation of lung epithelial functions by Pseudomonas aeruginosa. Trends
Microbiol13: 389-397.
-
Zhang S, Chen Y, Potvin E, Sanschagrin
F, Levesque RC, McCormack FX, Lau GW. 2005.Comparative signature-tagged
mutagenesis identifiesPseudomonas aeruginosa factors conferring resistance
to pulmonary collectin SP-A. PLoS Pathogens1: e31.
-
Yoon SS, Coakley R, Lau GW, Lymar SV,
Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen
JE, Burns JL, Speert D, Boucher RC, Hassett DJ. 2006.
Anaerobic killing of mucoid Pseudomonas aeruginosa by
acidified nitrite derivatives under cystic fibrosis airway conditions. J
Clin Invest116: 436-446.
-
Kong FS, Young LE, Ran H, Meyers M,
Chen Y, Joseph P, Hassett DJ, Lau GW. 2006. Pseudomonas aeruginosa pyocyanin
inactivates lung epithelial vaculoar ATPase-dependent CFTR expression and
localization. Cell Microbiol 8: 1121-1133.
-
Borchers MT, Harris NL, Wesselkamper
SC, Chen Y, Zhang S, Young L, Lau GW. 2006. The NKG2D activating receptor
mediates pulmonary clearance of Pseudomonas aeruginosa. Infect
Immun74: 2578-2586.
-
Zhang S,McCormack FX, Levesque RC,
O’Toole G, Lau GW. 2007. The flagellar protein, FlgE, is a molecular target for
clearance of Pseudomonas aeruginosa by SP-A. PLoS One2: e564.
-
Platt MD, Schurr MJ, Sauer K, Vazquez
G, Kukavica-Ibrulj I, Potvin E, Levesque RC, Fedynak A, Brinkman FSL, Schurr J,
Hwang SH, Lau GW et al. 2008. Proteomic, microarray and signature tagged
mutagenesis analysis of anaerobic Pseudomonas aeruginosa at pH 6.5,
representing chronic cystic fibrosis airway conditions. J
Bacteriol190: 2739-2758.
-
Wesselkamper SC, Eppert BL, Motz GT,
Lau GW, Hassett DJ, Borchers MT. 2008. NKG2D is critical for NK cell
activation in host defense againstPseudomonas aeruginosa respiratory
infection. J Immunol 181: 5481-5489.
-
Caldwell CC, Chen Y, Goetzmann H, Hao
H, Borchers MT, Hassett DJ, Young LR, Mavrodi D, Thomashow L, Lau GW. 2009. Pseudomonas
aeruginosapyocyanin causes cystic fibrosis airway pathogenesis. Am J
Pathol175: 2473-88.
-
Hassett DJ, Korfhagen TR, Irvin RT,
Schurr MJ, Sauer K, Lau GW, Sutton M, Hoiby N. 2010.Pseudomonas
aeruginosaBiofilm Infections in Cystic Fibrosis: Insights Into Pathogenic
Processes and Treatment Strategies. Expert Opinion On Therapeutic
Targets14: 117-130.
-
Kuang ZZ, YH Hao, SH Hwang, S Zhang, E
Kim, HT Akinbi, MJ Schurr, RT Irvin, DJ Hassett and Lau GW. 2011. The flagella
of Pseudomonas aerugniosamediate resistance to SP-A-mediated membrane
permeabilization by multiple mechanisms.Mol Microbiol79:1220-1235.
-
Zhu L, Lau GW. 2011.Inhibition of
Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus
pneumoniae by A Modified Competence Stimulating Peptide. PLoS
Pathogens7:e1002241.
-
Kuang ZZ, Hao YH, Walling BE, Jeffries
JL, Lau GW. 2011. Pseudomonas aeruginosa elastase provides an escape
from phagocytosis by degradation of pulmonary surfactant protein A. PLoS
One: e27091.
-
Hao Y, Kuang Z, Walling BE, Bhatia S,
Sivaguru M, Chen Y, Gaskins HR, Lau GW. 2012.Pseudomonas aeruginosapyocyanin
causes airway goblet cell hyperplasia and mucus hypersecretion by inactivating
the transcriptional factor FoxA2.Cell Microbiol14:401-15.
Profile Details
http://illinois.edu/ds/searchsearch_type=userid&search=geelau&skinId=333