Biography

Cang-Bao Xu, MD, Ph.D.
Division of Experimental Vascular Research,
Institute of Clinical Science in Lund
Lund University, Sweden

Associate Professor

College of Medicine, Xian Jiaotong University, China

China Adjunct Professor,

Xian Medical University, China

Distinguished Professor

 

Email: Cang-Bao.Xu@med.lu.se
 
Qualifications

 

1989-1993   Ph.D., Faculty of Medicine, Lund University, Sweden
1978-1982   M.S., Xian Medical University, China

 

Publications (Selected)

  1. Cao L, Zhang Y, Cao YX, Edvinsson L, Xu CB. Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS One, 7(3):e33008 2012 
  2. Grigg J, Walters H, Sohal SS, Wood-Baker R, Reid DW, Xu CB, Edvinsson L, Morissette MC, Stämpfli MR, Kirwan M, Koh L, Suri R, Mushtaq N. Cigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cells. Thorax. 2012 May 1. [Epub ahead of print] PMID:22550083
  3. Zhang W, Li XJ, Zeng X, Shen DY, Liu CQ, Zhang HJ, Xu CB, Li XY. Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro. Toxicol Lett., 7;209(2):107-12 2012 
  4. Li J, Cao YX, Liu Y, Xu CB. Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. Microvasc Res., 83(2):178-84 2012 
  5. Li J, Cao YX, Yuan ZY, Xu CB. Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-κB pathways. Biochim Biophys Acta., 1821(4):582-589 2011 
  6. Cao L, Xu CB, Zhang Y, Cao YX, Edvinsson L. Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors. BMC Neurosci., 12(1):109 2011
  7. Cai Y, Cao YX, Lu SM, Xu CB, Cardell LO. Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats. Int Immunol., 23(7):443-51  2011
  8. Sandhu H, Xu CB, Edvinsson L. Alteration in contractile G-protein coupled receptor expression by moist snus and nicotine in rat cerebral arteries. Toxicol Appl Pharmacol., 252(2):138-49 2011 
  9. Lei Y, Cao Y, Zhang Y, Edvinsson L, Xu CB. Enhanced airway smooth muscle cell thromboxane receptor signaling via activation of JNK MAPK and extracellular calcium influx. Eur J Pharmacol., 650(2-3):629-38 2011 
  10. Tajti J, Kuris A, Vécsei L, Xu CB, Edvinsson L. Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2. Cephalalgia, 31(1):95-105 2011 
  11. Zhang Y, Edvinsson L, Xu CB. Up-regulation of endothelin receptors induced by cigarette smoke — involvement of MAPK in vascular and airway hyper-reactivity. ScientificWorldJournal., 10:2157-66 2010 
  12. Chen QW, Edvinsson L, Xu CB. Cigarette smoke extract promotes human vascular smooth muscle cell proliferation and survival through ERK1/2- and NF-κB-dependent pathways. ScientificWorldJournal, 10:2139-56 2010
  13. Sandhu H, Xu CB, Edvinsson L. Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK. Toxicol Appl Pharmacol., 249(1):25-32 2010 
  14. Xu CB, Lei Y, Chen QW, Pehrson C, Larsson L, Edvinsson L. Cigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airway. Basic Clin Pharmacol Toxicol., 107(6): 940-8 2010  
  15. Xu CB, Sun Y, Edvinsson L. Cardiovascular risk factors regulate the expression of vascular endothelin receptors. Pharmacol Ther., 127(2):148-55 2010  
  16. Li J, Cao YX, Chen KL, Cao L, Ma Z, Xu CB. Regional variations of vasomotion to G-protein coupled receptor agonists following heat stress in rats. J Pharm Pharmacol., Mar;62(3):315-22. 2010
  17. Xie YH, Wang SW, Zhang Y, Edvinsson L, Xu CB. Up-Regulation of G-Protein-Coupled Receptors for Endothelin and Thromboxane by Lipid-Soluble Smoke Particles in Renal Artery of Rat. Basic Clin Pharmacol Toxicol., 107(4): 803-12. 2010  
  18. Zheng JP, Zhang Y, Edvinsson L, Hjalt T, Xu CB. NF-kappaB signaling mediates vascular smooth muscle endothelin type B receptor expression in resistance arteries. Eur J Pharmacol., 637(1-3):148-54 2010 
  19. Lei Y, Zhang Y, Cao Y, Edvinsson L, Xu CB. Up-regulation of bradykinin receptors in rat bronchia via IkappaB kinase-mediated inflammatory signaling pathway. Eur J Pharmacol., 634(1-3):149-61 2010 
  20. Zhang JY, Cao L, Zheng XH, Xu CB, Cao YX. Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility. Arch Pharm Res., 32(10): 1475-1481 2009
  21. Chen Q, Edvinsson L, Xu CB. Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells. BMC Cell Biol., 10:52. 2009 
  22. Zhang Y, Xu CB, Cardell LO. Long-term exposure to IL-1β enhances Toll-IL-1 receptor-mediated inflammatory signaling in murine airway hyperresponsiveness. Eur Cytokine Netw., 20(3):148-56 2009 
  23. Lindstedt I, Xu CB, Zhang Y, Edvinsson L. Increased perfusion pressure enhances the expression of endothelin (ETB) and angiotensin II (AT1, AT2) receptors in rat mesenteric artery smooth muscle cells. Blood Press., 18(1):78-85  2009
  24. Vikman P, Xu CB, Edvinsson L. Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag., 5(1):333-41 2009 
  25. Zhang W, Zhang Y, Edvinsson L, Xu CB. Transcriptional down-regulation of thromboxane A(2) receptor expression via activation of MAPK ERK1/2, p38/NF-kappaB pathways. J Vasc Res., 46(2):162-74. 2009
  26. Refereed Conference Publications
  27. Li J, Cao YX, Yuan ZY, Xu CB. Minimally modified LDL upregulates endothelin receptors in rat basilar artery via the PKC, MAPK and NF-κB signalling pathways. Basic Clin Pharmacol Toxicol. 107 Suppl 1, 2010, and the 16th World Congress of Basic and Clinical Pharmacology. July 17-23, Copenhagen, Denmark (Abstract). 
  28. Cao L, Zhang Y, Cao YX, Edvinsson L, Xu CB. Long-term cigarette smoke exposure induces bronchial
  29. hyperresponsiveness to G-protein coupled receptor agonists. Basic Clin Pharmacol Toxicol. 107 Suppl 1, 2010, and the 16th World Congress of Basic and Clinical Pharmacology. July 17-23, Copenhagen, Denmark (Abstract). 
  30. Cao L, Zhang Y, Cao YX, Edvinsson L, Xu CB. Increased sensitivity of cerebral and coronary arteries to GPCR agonists in spontaneously hypertensive rats. Basic Clin Pharmacol Toxicol. 107 Suppl 1, 2010, and the 16th World Congress of Basic and Clinical Pharmacology. July 17-23, Copenhagen, Denmark (Abstract). 
  31. Cai Y, Cao YX, Lu SM, LeiY, Xu CB, Cardell LO. Infliximab alleviates airway inflammation and hyperreactivity in asthmatic E3 rats. Basic Clin Pharmacol Toxicol. 107 Suppl 1, 2010, and the 16th World Congress of Basic and Clinical Pharmacology. July 17-23, Copenhagen, Denmark (Abstract). 
  32. Zhang Y, Zheng JP, Zhang W, Edvinsson L, Xu CB. LDL increases vascular ETB2 receptor expression via activation of ERK1/2 and p38 MAPK pathways. The 78th European Atherosclerosis Society Congress (EAS 2010), June 20-23, 2010, Hamburg, Germany (Absract). 
  33. Zhang Y, Zhang W, Edvinsson L, Xu CB. Attenuation of endothelium-dependent relaxation in rat mesenteric arteries by ApoB protein of low density lipoprotein, but not cholesterol. Hypertension, 52(4):768. 2008 (Abstract) 
  34. Xu CB, Zhang Y, Zhang W, Edvinsson L. The cardiovascular risk factor DMSO-soluble smoke particles enhance transcription and translation of endothelin type A receptors via activation of PKCε and ERK1/2 pathways in vascular smooth muscle cells. Hypertension, 52(4):770. 2008 (Abstract)
    35.  

Webpage:
http://www.research.med.lu.se/en_projektdetaljer.php?Proj=594
http://www.cangbaoxu.com/wordpress/

 

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