Biography

Craig M. Walsh

University of California at Irvine, USA


Email: cwalsh@uci.edu


Qualifications

1995 Ph.D., University of California at Los Angeles, USA

1988 B.S., University of California at Los Angeles, USA


Publications(Selected)

  1. Walsh, C.M., Glass, A.A., Chiu, V., and W.R. Clark.  1994.  The role of the Fas lytic pathway in a perforin-less CTL hybridoma.Journal of Immunology, 153(6):2506-2514.
  2. Walsh, C.M., Matloubian, M., Liu, C.-C., Ueda, R., Kurahara, C.G., Christensen, J.L., Huang, M.T.F., Young, J.D.-E,  Ahmed, R., and W.R. Clark.  Immune function in mice lacking the perforin gene.Proceedings of the National Academy of Sciences, USA91:10854-10858.
  3. Chiu, V.K.,Walsh, C.M., Liu, C.-C., Reed, J.C., W.R. Clark.  1995.bcl-2blocks degranulation- but not fas-based cell-mediated cytotoxicity.Journal of Immunology154: 2023-2032.
  4. Clark, W.R.,Walsh, C.M., Glass, A.A., M.T.F. Huang, Ahmed, R., and M. Matloubian.  1995.  Cytotoxic responses in perforin-less mice.International Reviews of Immunology13: 1-14.
  5. Liu, C.-C.,Walsh, C.M., and J.D.-E. Young.  1995.  Perforin: Structure and Function.Immunology Today16: 194-201.
  6. Clark, W.R.,Walsh, C.M., Glass, A.A., Hayashi, F., Matloubian, M., Ahmed, R. 1995.  Molecular pathways of CTL-mediated cytotoxicity.Immunological Reviews146: 33-44.
  7. Liu, C.-C.,Walsh, C.M., Eto, N., Clark, W.R., Young J.D-E. 1995.  Morphological and functional characterization of perforin-deficient lymphokine activated killer cells.Journal of Immunology.  155: 602-608.
  8. Glass, A.,Walsh, C.M., Lynch, D.H. and Clark, W.R. 1996.  Regulation of the Fas lytic pathway in cloned CTL.Journal of Immunology156: 3638-44.
  9. Walsh C.M., Hayashi F., Saffran D.C., Ju S-T, Berke G, Clark W.R.  1996.  Cell-mediated cytotoxicity results from, but may not be critical for, primary allograft rejection.Journal of Immunology156: 1436-41.
  10. Clark, W.R.,Walsh, C.M., Matloubian, M., Glass, A.A., Hayashi, F.  1996.  Mechanisms of CTL-mediated cytotoxicity.Seminars in Virology7: 113-116.
  11. Spencer MJ,Walsh C.M., Dorshkind KA, Rodriguez EM, Tidball JG.  1997.  Myonuclear apoptosis in dytrophic mdx muscle occurs by perforin-mediated cytotoxicity.J. Clin. Invest.99: 2745-2751.
  12. Walsh C.M., Wen B.G., Chinnayan A.M., O’Rourke K.O., Dixit V.M., Hedrick S.M.  1998.  A role for FADD in T cell activation and development.Immunity8: 439-449.
  13. Matloubian M., Suresh M., Glass A., Galvan M., Chow K., Whitmire J.K.,Walsh C.M., Clark W.R., Ahmed R.  1999. A role for perforin in downregulating T-cell responses during chronic viral infection.J Virol.73: 2527-36.
  14. BeisnerD., Chu I.H., Arechiga A.F., Hedrick S.M.,Walsh C.M.  2003. The requirements for FADD signaling in mature T cell activation and survival.Journal of Immunology17: 247-56.
  15. Walsh C.M., Luhrs K.A., Arechiga A.F.  2003. The “fuzzy logic” of the death-inducing signaling complex in lymphocytes.Journal of Clinical Immunology23:333-353.
  16. Li C., Arechiga A.F., Melo J.V.,Walsh C.M., Ong S.T.  2003. Bcr-Abl Kinase Modulates the Translation Regulators Ribosomal Protein S6 and 4E-BP1 in Chronic Myelogenous Leukemia Cells via mTOR.Cancer Research63:5716-5722.
  17. McCargill M., Wen B.,Walsh C.M., Hedrick S.M. 2004.A deficiency inDrak2results in a T cell hypersensitivity, and an unexpected resistance to autoimmunity.Immunity21:781-791.
  18. Friedrich M.L., Wen B.G., Bain G., Kee B., Murre C., Hedrick S.M.,Walsh C.M.2005.DRAK2, a lymphoid-enriched DAP kinase, regulates the T cell receptor activation threshold during thymocyte selection.International Immunology,17: 1379-1390.
  19. Arechiga A.F., Bell B.D., Solomon J.C., Chu I.H., Dubois C.L., Hall B.E., George T.C., Coder D.M.,Walsh C.M.2005.Cutting Edge- FADD is not required for antigen receptor mediated NF-kappaB activation.Journal of Immunology 175: 7800-7804.
  20. Sandu S., Morisawa G., Wegorzewska I., Huang T., Arechiga A.F., Hill J.M., Kim T.,Walsh C.M., Werner M.H. 2006. FADD self-association is required for stable association with an activated death receptor.Cell Death and Differentiation 13: 2052-2061.
  21. Choudhary S.K., Walker R.M., Powell D.M., Planelles V.,Walsh C., Camerini D. 2006. CXCR4 Tropic Human Immunodeficiency Virus Type 1 Induces an Apoptotic Cascade in Immature Infected Thymocytes that Resembles Thymocyte Negative Selection.Virology 352:268-84.
  22. Werner M.H., Wu C.,Walsh, C.M.2006. Perspective - Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation.Cell Cycle 5(20): 2332-38.
  23. Ramos S.J.*, Hardison J.L.*, Stiles L.N., Lane T.E.,Walsh C.M.2007. Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system.Autoimmunity 40: 54-65.
  24. Doskaya M., Kalantari-Dehaghi M.,Walsh C.M., Hiszczynska-Sawicka E., Davies D.H., Felgner P.L., Larsen L.S.Z., Lathrop R.H., Hatfield G.W., Schulz J.R., Yuksel G., Jurnak F. 2007. GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine.Vaccine 25:1824-1837.
  25. Friedrich M.L., Cui M., Hernandez J.B., Weist B.M., Andersen H.M., Zhang X., Huang L.,Walsh C.M.2007. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes.Journal of Biological Chemistry 282: 4573-84.


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