Prof. Kota V. Ramana
Department of Biochemistry and Molecular Biology
University of Texas Medical Branch, USA
Professor
Email: kvramana@utmb.edu
Qualifications
1998 Ph.D., Postgraduate Institute of Medical Education and Research, Chandigarh, India, Biochemistry
1994 M.Sc., Indian Institute of Technology, Roorkee, India, Biosciences
1989 B.Sc, Nagarjuna University, Guntur, India, Chemistry
Publications (Selected)
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Shoeb M and
Ramana KV. Anti-Inflammatory Effects of Benfotiamine are Mediated through the
Regulation of Arachidonic Acid Pathway in Macrophages. Free Rad Biol Med.
52(1):182-90. 2012
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Shoeb M,
Srivastava SK and Ramana KV. Inhibition of Aldose Reductase Prevents
Endotoxin-Induced Inflammation by Regulating Arachidonic Acid Pathway in Murine
Macrophages. Free Rad Biol Med. 51(9):1686-96, 2011
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Yadav UCS,
Shoeb M, Srivastava SK, Ramana KV. Amelioration of Experimental Autoimmune
Uveoretinitis by Aldose Reductase Inhibition in Lewis Rats. Invest Ophthalmol
Vis Sci. 52(11):8033-41, 2011
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Yadav UCS,
Shoeb M, Srivastava SK and Ramana KV. Aldose reductase deficiency protects from
autoimmune- and endotoxin –induced uveitis in mice. Invest Ophthalmol Vis Sci
52(11):8076-85, 2011
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Tammali R,
Reddy ABM, Srivastava SK and Ramana KV. Aldose reductase inhibition prevents
angiogenesis in vitro and in vivo. Angiogenesis. 14:209-221, 2011
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Tammali R,
Saxena A, Srivastava SK and Ramana KV. Aldose reductase inhibition prevents
hypoxia-induced increase in HIF-1a and VEGF by regulating the 26S proteasome
mediated protein degradation in human colon cancer cells. J. Biol. Chem.
286(27):24089-100, 2011
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Ramana KV.
Aldose reductase: New insights for an old enzyme. Biomol Concepts. 2:103-114,
2011
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Yadav UC,
Kalariya NM and Ramana KV. Emerging role of antioxidants in the prevention of
uveitis complications. Curr Med Chem. 18:931-942, 2011
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Tammali R,
Srivastava SK and Ramana KV. Targeting Aldose Reductase for the Prevention of
Cancer. Curr Cancer Drug Tar. 11:560-571, 2011
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Reddy AB,
Srivastava SK, Ramana KV. Aldose reductase inhibition prevents
lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression
in RAW264.7 macrophages. Int J Biochem Cell Biol. 42:1039-1045, 2010
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Yadav UC,
Sriavstava SK and Ramana KV. Inhibition of Aldose Reductase Attenuates
Endotoxin Signals in Human Non-pigmented Ciliary Epithelial Cells. Exp. Eye
Res. 90:555-563, 2010
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Yadav UC,
Kalariya NM, Reddy ABM, Srivastava SK and Ramana KV. Protective role of
benfotiamine, a fat soluble vitamin B1 analogue, in the lipopolysaccharide
-induced cytotoxic signals in murine macrophages. Free Rad. Biol. Med.
48:1423-34, 2010
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Tammali R,
Srivastava SK and Ramana KV. Aldose reductase regulates vascular smooth muscle
cell proliferation by modulating g1/s phase transition of cell cycle.
Endocrinology 151:2140-2150, 2010
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Ramana KV and
Srivastava SK. Aldose reductase: A novel therapeutic target for inflammatory
pathologies. Int J Bichem Cell Biol. 42:17-20, 2010
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Yadav UC,
Igani HF, VanKuijk FJ, Srivastava SK and Ramana KV. Aldose Reductase Inhibition
Prevents Posterior Capsular Opacification in Porcine Eye Capsular Bag Model.
Invest Ophthalmol Vis Sci. 50:752-759, 2009
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Tammali R,
Reddy ABM, Ramana KV and Srivastava SK. Aldose Reductase Deficiency in Mice
Prevents Azoxymethane –Induced Colonic Preneoplastic Aberrant Crypt Foci
Formation. Carcinogenesis 30:799-807, 2009
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Ramana, K.V.,
Willis, M.S., White, M.D., Horton, J.W., DiMaio, J.M., Srivastava, D.,
Bhatnagar, A. and Srivastava, S.K. Endotoxicn-induced cardio myopathy and
septic inflammatory in mice is prevented by aldose reductase inhibiton.
Circulation 114: 1838-1846, 2006
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Ramana, K.V.,
Fadl, A.A., Reddy, A.B.M., Tammali, R., Chopra, A.K. and Srivastava, S.K.
Aldose reductase mediated the lipopolysacharide-induced release of inflammatory
mediators in RAW264.7 murine macrophages. J. Biol. Chem. 281(44):33019-29,
2006
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Tammali, R.,
Ramana, K.V. and Srivastava, S.K. Aldose reductase growth factor-induced
cox-2 expression and PGE2 production in human colon cancer cells. Cancer
Res. 66: 1-9, 2006
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Ramana, K.V.,
Bhatnagar, A., Awasthi, S., Yadav, U.C.S., Awasthi, Y.C. and Srivastava, S.K.
Mitogenic responses of vascular smooth muscle cells to lipid peroxidation
derived aldehdye 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase
catalyzed reduction of the HNE-glutathione conjugates in regulating cell
growth. J. Biol. Chem. 281: 17652-17660, 2006
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Ramana, K.V.,
Bhatnagar, A. and Srivastava, S.K. Inhibition of aldose reductase attenuates
TNF-α-induced expression of adhesion molecules in endothelial cells. FASEB
J. 18: 1209-1218, 2004
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Ramana, K.V.,
Friedrich, B., Srivastava, S., Bhatnagar, A. and Srivastava, S.K. Activation of
NF-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose
reductase. Diabetes 53: 2910-2920, 2004
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Ramana, K.V.,
Friedrich, B., Bhatnagar, A. and Srivastava, S.K. Requirement of aldose
reductase for the hyperglycemic activation of protein kinase C and formation of
diacylglycerol in vascular smooth muscle cells. Diabetes 54: 818-829, 2005
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Srivastava,
S.K., Ramana, K.V., and Bhatnagar, A. Role of aldose reductase and oxidative
damage in diabetes and the consequent potential for therapeutic options.
Endocrine Reviews 26:380-392, 2005
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