Prof. Kevin D. Brown

University of Florida Shands Cancer Center, USA

Email: kdbrown1@ufl.edu

Qualifications

1991 Ph.D., University of Alabama, Cell & Molecular Biology

1987 M.A., Francisco State University, Cell & Molecular Biology

1981 B.Sc., University of Massachusetts, Medical Technology

Publications (selected)

1. Turner J, Koumenis C, Kute TE, Planalp RP, Brechbiel MW, Beardsley DI, Cody B, Brown KD, Torti FM, Torti SV. 2005. Tachpyridine, a metal chelator, induces G2 cell cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood, 106: 3191-3199.
2. Ai, L, Tao, Q, Zhong, S, Fields, CR, Kim, W-J, Lee, MW, Cui, Y, Brown, KD and Robertson, KD. 2006. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis, 27: 1341-48.
3. Ai, L, Kim, W-J, Kim, T-Y, Fields, CR, Massoll, NA, Robertson, KD, Brown, KD. 2006. Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. Cancer Research, 66: 7899-7909.
4. Kim, WJ, Rajasekaran, B, and Brown, KD. 2007. MLH1 and ATM-dependent MAP kinase signaling is activated through c-Abl in response to the alkylator N-methyl-N’-nitro-N-nitrosoguanidine J. Biol. Chem., 282: 32021-32031.
5. Lee, MW, Kim, WJ, Beardsley, DI and Brown, KD. 2007. N-methyl-N’-nitro-N-nitrosoguanidine activates both caspase-dependent and independent cell death mechanisms in human fibroblasts DNA and Cell. Biol., 26: 683-694.
6. Brown, KD and Robertson, KD. 2007. DNMT1 knockout delivers a strong blow to genome stability and cell viability. Nature Genetics, 39: 289-90.
7. Palii, S., Van Emburgh, B.O., Sankpal, U.T, Brown, K.D. and Robertson, K.D. 2008. The DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-azadC) induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases (DNMTs) 1 and 3B. Molec. Cell Biol., 28: 752-71.
8. Zheng, L., Asprodites, N., Keene, A.H., Rodriguez, P., K.D. Brown, and Davila, E. 2008. TLR engagement on CD4 T lymphocytes -radiation–induced repressesgapoptosis through activation of checkpoint kinase response elements. Blood, 111(5): 2704-13.
9. Ai, L., Kim, W-J, Demircan, B., Dyer, L.M., Bray, K.J., Skehan, R.R, Massoll, N.A., Brown, K.D. 2008. The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis, 29(3): 510-8.
10. Qiu, J., Ai, L., Ramachandran, C., Yao,B., Gopalakrishnan, S., Fields, C.R., Delmas, A.L,. Dyer, L.M., Melnick, S.J., Yachnis, A.T., Schwartz, P.H., Fine, H.A., Brown, K.D. and Robertson, K.D. 2008. Invasion suppressor cystatin E/M (CST6): High-level cell type-specific expression in normal brain and epigenetic silencing in brain tumors. Lab Invest., 9: 910-25.
11. Demircan, B., Dyer, LM, Gerace, M, Lobenhofer, E.K., Robertson, KD and Brown, KD. 2009. Comparative epigenomics of human and mouse mammary tumors. Genes, Chrom and Cancer, 48: 83-97.
12. Orlando, FA, and Brown, KD. 2009. Unraveling Breast Cancer Heterogeneity Through Transcriptomic and Epigenomic Analysis. Ann. Surg. Oncol., 16(8): 2270-9.
13. Jiang Z, Jin S, Yalowich JC, Brown KD, Rajasekaran B. 2010. The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G2-M Checkpoint. Mol Cancer Ther., 9: 558-68.
14. Dyer LM, Schooler KP, Ai L, Klop C, Qiu J, Robertson KD, Brown KD. 2011. The transglutaminase 2 gene is aberrantly hypermethylated in glioma. J Neurooncol., 101: 429-40.
15. Delmas, AL, Riggs, BM, Pardo, CE, Dyer, LM, Darst, RP, Izumchenko, E, Monroe, M, Hakam, A, Kladde, MP, Siegel, EM and Brown, KD. 2011. WIF1 is a Frequent Target for Epigenetic Silencing in Squamous Cell Carcinoma of the Cervix. Carcinogenesis, 32: 1625-33.
16. Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. 2012. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer Ther., 11: 370-82.
17. Ai, L, Skehan, RR, Saydi, J, Lin, T, and Brown, KD Ataxia-Telangiectasia, Mutated (ATM) / Nuclear Factor Kappa light chain enhancer of activated B cells (NF kappaB) Signaling Controls Basal and DNA Damage-Induced Transglutaminase 2 Expression. J. Biol. Chem. (in press).