Dr. Thierry Dubois

Breast Cancer Biology Group, France

Email: thierry.dubois@curie.fr

Qualifications

1995 Ph.D., University of Paris 6, Molecular and Cellular Pharmacology

Publications (selected)

1. Quanz M, Herbette A, Sayarath M, de Koning L, Dubois T, Sun JS, Dutreix M (2012) Heat shock protein 90α (hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci. J. Biol. Chem. 287(12):8803-8815
2. Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, Richardson M, Rigaill G, Parrini MC, Lucchesi C, Bellanger D, Stern MH, Dubois T, Sastre-Garau X, Delattre O, Vincent-Salomon A & Mechta-Grigoriou F (2010) Oxidative stress promotes myofibroblast differentiation and tumor spreading. EMBO Mol. Med. 2, 211-230
3. Popova T, Manie E, Stoppa-Lyonnet D, Rigaill G*, Barillot E & Stern MH (2009) Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays. Genome Biol. 10:R128 (* Dubois’s lab)
4. Clokie S, Falconer H, Mackie S, Dubois T & Aitken A (2009) The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent. FEBS J. 276, 6971-6984.
5. Lizárraga-Sánchez F, Poincloux R, Romao M, Montagnac G, Le Dez G, Bonne I, Rigaill G*, Raposo G & Chavrier P (2009) Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res., 69, 2792-800 (* Dubois’s lab)
6. Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Hupé P, Barillot E, Cruzalegui F, Tucker GC, Stern MH, Thiery JP, Hickman JA & Dubois T (2008) Frequent PTEN genomic alterations and activated PI3K pathway in basal-like breast cancer. Breast Cancer Res. 10, R101
7. Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, Franco M, Chavrier P & Houdusse A (2007) Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J. 26, 1953-1962.
8. Dubois T, Paléotti O, Mironov AA Jr, Fraisier V, Stradal TEB, De Matteis MA, Franco M & Chavrier P (2005) Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nature Cell Biol. 7, 353-364.
9. Zemlickova E, Johannes FJ, Aitken A & Dubois T (2004) Association of CPI-17 with protein kinase C and casein kinase I. Biochem. Biophys. Res. Commun. 316, 39-47.
10. Dubois T, Colucci-Guyon E, Niedergang F, Prigent M & Chavrier P (2003) Regulation and function of the small GTP-binding protein ARF6 in membrane dynamics. In Cell Motility, Ed. John Wiley & Sons, Ltd. Edited by A. Ridley, M. Peckham, P. Clark. Chapter 10, 165-172.
11. Dubois T, Zemlickova E, Howell S & Aitken A (2003) Centaurin-alpha1 associates in vitro and in vivo with nucleolin. Biochem. Biophys. Res. Commun. 301, 502-508.
12. Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J & Chavrier P (2003) ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J. Cell Biol. 163, 1111-1121.
13. Niedergang F, Colucci-Guyon E, Dubois T, Raposo G & Chavrier P (2003) ARF6 is activated and controls membrane delivery during phagocytosis in macrophages. J. Cell Biol. 161, 1143-1150.
14. Dubois T, Howell S, Zemlickova E, Learmonth M, Cronshaw A & Aitken A (2003) Protein Phosphatase 1 Inhibitor CPI-17: Identification of Novel in vitro and in vivo Phosphorylation Sites. Biochem. Biophys. Res. Commun. 302, 186-192.
15. Dubois T, Howell S, Zemlickova E & Aitken A (2002) Identification of casein kinase I interacting protein partners. FEBS lett. 517, 167-171.
16. Graeser R, Gannon J., Poon R, Dubois T, Aitken A & Hunt T (2002) Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. J. Cell Sci. 115, 3479-3490.