Prof. Manijeh Pasdar

University of Alberta, Canada

Email: mpasdar@ualberta.ca

Qualifications

1984 Ph.D., University of Illinois, Genetics

1974 M.Sc., Pahlavi University, Animal Breeding

1971 B.Sc., Pahlavi University, Animal Science

Publications (selected)

1. Aktary Z, Pasdar M. Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. Plos One, 8(11):e78388.
2. Tang Y, Mackey J, Lai R, Ghosh S, Santos C, Graham K, Damaraju S, Pasdar M, Li L. Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification. J Proteomics. 2013 Jul 11;91C:200-209.
3. Aktary Z, Kulak S, Mackey JR, Jahroudi N., Pasdar M. Plakoglobin interacts with the transcription factor p53 and regulates the expression of the tumor suppressor 14-3-3s.  J Cell Sci. 2013 Jul 15;126(Pt 14):3031-42.
4. Lam L, Aktary Z, Bishay M, Werkman C, Kuo C-Y, Heacock M, Srivastava N, Mackey JR and Pasdar M. Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin. Oncogenesis 1: e4; doi:10.1038/oncsis.2012.4.
5. Aktary Z, Pasdar M. Plakoglobin: Role in Tumorigenesis and Metastasis. Invited Review, Int J Cell Biol. 2012;2012:189521.
6. Aktary Z, Chapman KA, Lam L, Ji C, Lo A, Cook L, Graham K, Mackey J, Li L, Pasdar M.  Plakoglobin interacts with, regulates the expression and increases the protein levels of non-metastatic protein 23 (Nm23). Oncogene, 2010;29:2118-29- Featured in MDLinx on Jan 28, 2010.
7. Asgarian N, Hu X, Aktary Z, Chapman KA, Lam L, Chibbar R, Mackey J, Greiner R, Pasdar M. Learning to predict relapse in invasive ductal carcinomas based on the  subcellular localization of junctional proteins. Breast Cancer Res Treat. 2010;121:527-38.
8. Lam L, Hu X, Aktary Z, Andrews DW, Pasdar M. Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERa. Breast Cancer Research and Treatment.  Breast Cancer Research and Treatment, 2009; 118: 605-621.
9. Li L, Chapman K, Hu X, Wong A, Pasdar M. Modulation of oncogenic potential of b-catenin by subcellular distribution of plakoglobin. Molecular Carcinogenesis 2007;46(10):824-38.
10. Ji C, Li L, Gebre M, Pasdar M, Li L Identification and quantification of differentially expressed proteins in E-cadherin deficient SCC9 cells and SCC9 transfectants expressing E-cadherin by dimethyl isotope labeling, LC-MALDI MS and MS/MS. J Proteome Res. 2005;4(4):1419-26. Erratum in: J Proteome Res. 2005;4(5):1872.
11. Pla P, Alberti C, Solov'eva O, Pasdar M, Kunisada T, Larue L. Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation. Pigment Cell Res. 2005;18(3):181-7.
12. Li L, Backer J, Wong AS, Schwanke EL, Stewart BG, Pasdar M. Bcl-2 expression decreases cadherin-mediated cell-cell adhesion. J Cell Sci. 2003 15;116(Pt 18):3687-700.
13. Hakimelahi GH, Shia KS, Pasdar M, Hakimelahi S, Khalafi-Nezhad A, Soltani MN, Mei NW, Mei HC, Saboury AA, Rezaei-Tavirani M, Moosavi-Movahedi AA. Design, synthesis, and biological evaluation of a cephalosporin-monohydroguaiaretic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate. Bioorg Med Chem. 2002;10(9):2927-32.
14. Gilchrist AJ, Meuser R, Turchinsky J, Shaw AR, Pasdar M, Dixon WT. Cell adhesion-mediated transformation of a human SCLC cell line is associated with the development of a normal phenotype. Exp Cell Res. 2002;276(1):63-78.
15. Rahn JJ, Dabbagh L, Pasdar M, Hugh JC. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer. 2001;91(11):1973-82.
16. Hakimelahi S, Parker HR, Gilchrist AJ, Barry M, Li Z, Bleackley RC, Pasdar M. Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2.  J Biol Chem. 2000;275(15):10905-11.
17. Jouneau A, Yu YQ, Pasdar M, Larue L. Plasticity of cadherin-catenin expression in the melanocyte lineage. Pigment Cell Res. 2000;13(4):260-72.