Dr. Abbes Belkhiri

Vanderbilt University Medical Center, USA

Email: Abbes.belkhiri@vanderbilt.edu

Qualifications

1995 Ph.D., University of Manitoba, Microbiology

1988 M.Sc., University of Reading, Reading

Publications (selected)

1. Belkhiri A, Buchko J, and Klassen GR. 1992. The 5S ribosomal RNA gene in Pythium species: Two different genomic locations. Molecular Biology & Evolution, 9(6): 1089-1102.
2. Belkhiri A, and Klassen GR. 1996. Diverged copy of 5S rRNA sequence adjacent to 5S rRNA gene in rDNA of Pythium pachycaule. Current Genetics, 29: 287-292.
3. Belkhiri A, and Klassen GR. 1997. A tandem array of 5S ribosomal RNA genes in Pythium irregular. Gene, 186: 155-159.
4. Hole AK, Belkhiri A, Snell LS, and Watson PH. 1997. CD44 variant expression and estrogen receptor status in breast cancer. Breast Cancer Research Treatment, 43(2): 165-173.
5. Belkhiri A, Richards C, Whaley M, and Orr FW. 1997. Increased expression of activated matrix metalloproteinase-2 by human endothelial cells after sub-lethal H2O2 exposure. Laboratory Investigation, 77(5): 533-539.
6. Hausner G, Belkhiri A, and Klassen GR. 2000. Phylogenetic analysis of the small subunit ribosomal RNA gene of the hypochytrid Rhizidiomyces apophysatus. Canadian journal of Botany, 78: 124-128.
7. Belkhiri A, Lytvyn V, Guilbaut C, Massie B, Nagler DK, Menard R. 2002. A non-invasive cell-based assay for monitoring proteolytic activity within a specific sub-cellular compartment. Analytical Biochemistry, 306(2): 237-246.
8. Tomkova K, Belkhiri A, El-Rifai W, and Zaika A. 2004. P73 isoforms can induce T-Cell Factor-Dependent Transcription in Gastrointestinal Cells. Cancer Research, 64: 6390-6393.
9. Belkhiri A, Zaika A, Pidkovka N, Knuutila S, Moskaluk C, and El-Rifai W. 2005. Darpp-32: a novel Antiapoptotic Gene in Upper Gastrointestinal carcinomas. Cancer Research, 65(15): 6583-6592.
10. Makani N, Belkhiri A, Moskaluk C, Knuutila S, Dar A, and El-Rifai W. 2006. Molecular Dissection of 17q12 amplicon in Upper Gastrointestinal Adenocarcinomas. Molecular Cancer Research, 4(7): 449-455.
11. Belkhiri A, Dar AA, Zaika A, Kelly M, and El-Rifai W. 2008. T-Darpp promotes cancer cell survival by upregulation of bcl2 through Akt-dependent mechanism. Cancer Research, 68: 395-403.
12. Dar AA, Zaika A, Piazuelo MB, Correa P, Koyama T, Belkhiri A, Washington K, Casttells A, Pera M, and El-Rifai W. 2008. Frequent overexpression of Aurora Kinase A in uppergastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer, 112: 1688-1698.
13. Belkhiri A, Dar AA, Peng D, Razvi MH, Rinehart C, Arteaga CL, and El-Rifai W. 2008. Expression of t-DARPP Mediates Trastuzumab Resistance in Breast Cancer Cells. Clinical Cancer Research, 14(14): 4564-4571.
14. Dar AA, Belkhiri A, Ecsedy J, Zaika A, and El-Rifai W. 2008. Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells. Cancer Research, 68(21): 8998-9004.
15. Wooin L, Belkhiri A, lockhart C, merchant N, Glaeser H, Harris EI, Washington MK, Zaika A, Kim RB, El-Rifai W. 2008. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Research, 68(24): 10315-10323.
16. Dar AA, Belkhiri A, and El-Rifai W. 2009. The Aurora Kinase A regulates GSK-3beta in gastric cancer cells. Oncogene, 28(6): 866-875.
17. Mukherjee K, Peng D, Brifkani Z, Belkhiri A, Pera M, Koyama T, Koehler EA, Revetta FL, Washington MK, and El-Rifai W. 2010. DARPP-32 is Over-expressed in Early Stages of Gastric Tumorigenesis. Surgery, 148(2): 354-363.
18. Vangamudi B, Peng DF, Cai Q, El-Rifai W, Zheng W, and Belkhiri A. 2010. t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Molecular Cancer, 9(1): 240.
19. Vangamudi B, Zhu S, Soutto M, Belkhiri A, and El-Rifai W. 2011. Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells. Molecular Cancer, 10: 32.
20. Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM jr, and El-Rifai W. 2011. Loss of TFF1 is associated with activation of NF-kB-mediated inflammation and gastric neoplasia in mice and humans. Journal of Clinical Investigation, 121(5): 1753-1767.
21. Zhu S, Belkhiri A, and El-Rifai W. 2011. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. Gastroenterology, 2011 July 7.