Biography

Prof. Sherven Sharma

University of California at Los Angeles, USA

Director


Email: sherven.sharma@va.gov, ssharma@mednet.ucla.edu


Qualifications


1996 Post-Doctorate Trainee, UCLA

1993 Ph.D., University of Southern California

1983 B.S., University of the South Pacific


Publications (selected)

  1. Huang M, Wang J, Lee P, Sharma S, Mao JT, Meissner H, Uyemura K, Modlin R, Wollman, J and Dubinett SM. Human Non - Small Cell Lung Cancer Cells Express a Type 2 Cytokine Pattern. Cancer Research 1995; 55: 3847 - 3853.
  2. Wang J, Huang M, Lee P, Komanduri K, Sharma S, G Chen, Dubinett SM. Interleukin - 8 inhibits Non - Small Cell Lung Cancer Proliferation: A Possible Role for Regulation of Tumor Growth by Autocrine and Paracrine Pathways. J.of Interferon and Cytokine Research 1996; 16: 53 - 60.
  3. Sharma S and Hill CK. Fast Neutron Energy Dependence of Mutation Induction in a Human Epithelial Teratocarcinoma Cell Line (P3). Radiation Research 1996; 145: 331 - 336.
  4. Mao JT, Huang M, Wang J, Sharma S, Lee P, Tashkin DT, Dubinett SM. Cocaine Down - Regulates IL-2 Induced Peripheral Blood Lymphocyte IL-8 and Interferon- Transcription and Protein Production. Cellular Immunology 1996; 172: 217 - 223.
  5. Dubinett SM, Huang M, Dhanani S, Economou J S, Wang J, Lee P, Sharma S, Dougherty G. J., McBride W. H. Down regulation of Murine Fibrosarcoma Transforming Growth Factor-Expression by Interleukin 7. JNCI 1995; 87: 593-597.
  6. Sharma S, Wang J, Huang M, Paul R, Lee P, McBride W, Economou J, Roth M, Kiertscher S, Dubinett SM. Interleukin 7 Gene Transfer in Non - Small Cell Lung Cancer Decreases Tumor Proliferation, Modifies Cell Surface Molecule Expression and Enhances Anti - Tumor Reactivity. Cancer Gene Therapy 1996; 3: 302 - 313.
  7. Huang M, Sharma S, Mao JT, Dubinett SM. Non - Small Cell Lung Cancer - Derived Soluble Mediators and Prostaglandin E2 Enhance Peripheral Blood Lymphocyte IL-10 Transcription and Protein Production. J. Immunol.1996; 157: 5512 - 5520.
  8. Hagenbaugh A, Sharma S, Dubinett SM, Wei SHY, Fowell D, Binder S, Aranda R, Cheroute H, Tsao B, Locksley RM, Moore KW, Kronenberg M. Altered Immune Responses in IL-10 Transgenic Mice. J. Exp. Med. 1997; 185: 2101-2110.
  9. Mao JT, Zhu Li, Sharma S, Chen Ken,Gulsurd J, Tashkin DP,Dubinett SM. The Role of Transforming Growth Factor b in Cocaine Induced Inhibition of Endothelial IL-8 Production. Cellular Immunology 1997; 181:38-43.
  10. Sharma S, Miller PW, Stolina M, Zhu Li, Huang M, Paul RW,Dubinett SM. Multicomponent Gene Therapy Vaccines for Lung Cancer: Effective Eradication of Established Murine Tumors In Vivo with Interleukin 7/Herpes Simplex Thymidine Kinase Transduced Autologous Tumor and Ex Vivo - Activated Dendritic Cells. Gene Therapy 1997; 4:1361-1370
  11. Huang M, Stolina M, Sharma S, Mao J.T, Zhu L, Miller P.W, Wollman J, Herschman H, Dubinett SM. Non –Small Cell Lung Cancer Cyclooxygenase -2 -Dependent Regulation of Cytokine Balance in Lymphocytes and Macrophages: Upregulation of IL-10 and Downregulation of IL-12 production. Cancer Research 1998; 58:1208- 1216.
  12. Miller PW, Sharma S, Stolina M, Ken Chen, Zhu LX, Paul RW, Dubinett SM. Dendritic Cells Augment GM-CSF/herpes Simplex Virus Thymidine Kinase Gene Therapy of Lung Cancer. Cancer Gene Therapy 1998; 5:380-389.
  13. Dubinett SM, Miller PW, Sharma S, Batra RK. Lung Cancer Gene Therapy. Hematology-Oncology Clinics of North America 1998; 12: 569-594.
  14. Sharma S, Stolina M, Lin Y, Miller PW, Kronenberg M, Dubinett SM. T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing both T Cell and APC Function. J.Immunol 1999; 163: 5020-5028.
  15. Miller PW, Sharma S, Stolina M, Butterfield L, Lin Y, Luo J, Dohadwala M, Batra RK, Economou JS, Dubinett SM. Intratumoral Administration of Adenoviral Interleukin-7 Gene-Modified Dendritic Cells Augments Specific Antitumor Immunity and Tumor Eradication. Human Gene Therapy 2000; 11: 53-65.
  16. Stolina M, Sharma S, Lin Y, Dohadwala M, Gardner B, Luo J, Zhu L, Kronenberg M, Miller PW, Lee J, Dubinett SM. Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Immunity by Altering the Balance of IL- 10 and IL-12 Synthesis. J. Immunol 2000; 164: 361-70.
  17. Sharma S, Stolina M, Luo J, Strieter RM, Burdick M, Zhu LX, Batra RK, Dubinett SM. SLC/6Ckine Mediates T Cell-Dependent Anti-Tumor Responses In Vivo. J. Immunol 2000; 164: 4558-4563
  18. Batra, R.K., Bradley Henkle, Brian Gardner, Sharma S, and S. M. Dubinett. Adenoviral Gene Transfer is Inhibited by Soluble Factors in Malignant Pleural Effusions. Amer. Journal of Resp. Cell and Molecular Biology 2000, 22:613-619.
  19. Li X. Zhu, Sherven Sharma, Marina Stolina, Brian Gardner, Michael D. Roth, Donald P. Tashkin, Steven M. Dubinett. Delta-9 tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway. J. Immunol 2000; 165(1):373-380.
  20. Dubinett S. M., Batra R.K., Miller P.W., Sherven Sharma. Tumor Antigens in Thoracic Malignancy. Am. J. Respir. Cell Mol Biol 2000; 22: 524-527.
  21. Dohadwala M, Luo J, Zhu L, Lin Y, Dougherty GJ, Sharma S, Huang M, Põld M, Batra RK, Dubinett SM. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. Journal of Biological Chemistry 2001; 276: 20809-20812.
  22. Huang M, Batra RK, Kogai T, Lin YQ, Hershman JM, Lichtenstein A, Sharma S, Zhu LX, Brent GA, Dubinett SM. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer. Cancer Gene Ther 2001; 8: 612-618

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