Biography

Prof. Cosmas O. Okoro

Tennessee State University, USA


Email: cokoro@Tnstate.edu


Qualifications

2000 Postdoctor, Medicinal Chemistry, University of Kansas, USA

1995 Postdoctor, Medicinal Chemistry, Florida A&M University, USA

1993 Ph.D., Organic Chemistry, Howard University, USA

1986 B.Sc., Chemistry, North Carolina Central University, USA


Publications (selected)

  1. Jongoh Choi, Tiffany L. Wilson, Ana M. Ly,Cosmas O. Okoro,Udobi C. Onubogu, and Kinfe K. Redda, “Synthesis of Some N-(phenylsulfonylamino)-1,2,3,6-Tetrahydropyridines as Potential Anti-inflammatory Agents.” Med. Chem. Res.1995,5, 281-295.
  2. Clanicia A. Pelle,Cosmas O. Okoro,Tiffany L. Wilson, Udobi C. Onubogu, Kyoung-Jin Yoon, and Kinfe K. Redda, “Synthesis of Several N-(Substituted Phenylcarbonylamino)-4-(3-Cyclohexenyl)-1,2,3,6-Tetrahydropyridines as potential Anti-inflammatory Agents.” Synth. Commun.1996,26(14), 2703-2714.
  3. Cosmas O. Okoro,Tiffany L. Wilson, Jongoh Choi, and Kinfe K. Redda, “Synthesis and Antiinflammatory Activity Determination of Some N-(Substituted Phenylcarbonylamino)-4-(1-Hydroxymethylphenyl)-1,2,3,6-Tetrahydropyridines,” Med.Chem. Res.1997,7(1), 1-15.
  4. Y.M. Hiiji, P.F. Hudrlik,C.O. Okoro, and A.M. Hudrlik. “Preparation of O-(Silyl)Benzyl Alcohols” Synth. Commun.1997, 27, 4297-4308
  5. CosmasO.Okoro, Kyoung Jin P.Yoon, Tiffany L. Wilson, Udobi C. Onubogu, Tanya S. Eckford and Kinfe K. Redda. “Synthesis and Biological Evaluation of N-(Substituted Benzoylamino)-5-carbethoxymethyl -1,2,3,6-Tetrahydropyridines as Potential Anti-inflammatory and Hyperglycemic Agents.” Med. Chem. Res.1999, 9(2) 133-148.
  6. P.F. Hudrlik, J.O. Arango, Y.M. Hijji, C.O. Okoro and A.M. Hudrlik. “Alkoxides of O-Silyl Benzyl Alcohols in Cleavage Reactions: Approaches to Benzyl and Silyl Anion Equivalents.” Can. J. Chem.2000, 78, 1421-1427
  7. P.F. Hudrlik,C.O. Okoro, and A.M. Hudrlik. “Generations of a Silyl Anion Equivalent by Intramolecular Alkoxide Attack at Silicon.” NIGMS Symposium1991, 483, 130.
  8. P.F. Hudrlik, Y.M. Abdallah,C.O. Okoroand A.M. Hudrlik. “Rearrangemnet of Organosilicon Compounds.” ACS Symposium Series1992, 242.
  9. P.F. Hudrlik, Y.M. Abdallah,C.O. Okoroand A.M. Hudrlik. “Benzyloxysilanes Cleavage and Rearrangement Reactions.” XXVII Organosilicon Symposium1993, G10.
  10. C. A. Pelle,C.O. Okoro, T.L. Wilson, U.C. Onubogu, K.J. Yoon, and K.K. Redda. “Synthesis and Characterization of Several N-(Substituted Phenylcarbonylamino)-4-Cyclohexenyl-1,2,3,6-Tetrahydropyridines.” NIGMS Symposium1995, A-11, 5.
  11. C.O.Okoro, U.C. Onubogu, T.S. Eckford, C.A. Pelle, T.L. Wilson and K.K. Redda. “The Synthesis and Biological Evaluation of N-(Substituted-Phenylcarbonylamino)-3-Carboethoxymethyl-1,2,3,6-Tetrahydropyridine as Potential Anti-inflammatory and Hyperglycemic Agents.” 210thACS National Meeting, Chicago, Aug.20-24,1995, MEDI 90.
  12. C.O. Okoro, T.L. Wilson, J. Choi and K.K. Redda. “Synthesis of N-(Substituted –Phenylcarbonylamino)-4-(1-Hydroxymethylphenyl)-1,2,3,6-Ttrahydropyridines as Potential Hyperglycemic and Anti-inflammatory Agents.” NIGMS Symposium1995, A-12, 5.
  13. C.O.Okoro. “The Role of Chemistry and Chemicals in Health and Medicine.” University of Arkansas Pine Bluff-National Center for Toxicological Research Biomedical Seminar Series, April 13,1998.
  14. C.O.Okoroand G.L. Grunewald. “Synthesis of 7-N-ethylsulfonyl-1,2,3,4-tetrahydroisoquinoline as Selective Inhibitor of Phenylethanolamin-N-Methyltransferase (PNMT) versus a2–Adrenoceptor Affinity.” 23rdAnnual Research Symposium, Tennessee State University, March 20-21,2001.
  15. Patrice Jackson andC. O. Okoro. “Fluorinated Enaminones as reactive intermediates in Organic Synthesis.” 24thAnnual Research Symposium, Tennessee State University, March 19-20, 2002.
  16. 16. Cosmas O. Okoro, Tifann L. Wilson, and Kinfe K. Redda. “Conformational Analysis andMolecular Properties of N-(Substituted Phenylcarbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyridines,” Current Medicinal Chemistry, 2003, 10. 313-320.
  17. Cosmas O.Okoroand Patrice L. Jackson, “Synthesis, Conformational Analysis and Molecular Properties of New Trifluoromethyl Enaminone”, Abstracts, 55thSoutheast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 16-19, 2003 (2003), 565. Publisher, American Chemical Society, Washington, D.C. CODEN: 69EUCH Conference; Meeting Abstract written in English. AN2004: 129444. CAPLUS (Copyright 2004 ACS on SciFinder(R)).
  18. Jessica Gadsden,Elaine Sanders-Bush, andCosmas Okoro, “Acute Clozapine exposure does not desensitize 5-HT2CReceptors in vitro”, Abstracts, 55thSoutheast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 16-19, 2003 (2003), 167. Publisher, American Chemical Society, Washington, D.C. CODEN: 69EUCH Conference; Meeting Abstract written in English. AN2004: 132310. CAPLUS (Copyright 2004 ACS on SciFinder(R)).
  19. Brown, Patrick;Okoro, Cosmos O. “Pharmacophore Analysis of hSert and hNet inhibitors” Abstracts, 57thSoutheast/61stSouthwest joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 (2005), NOV04-402: Publisher: American Chemical Society, Washington, D. C. CODEN: 69HOKM Conference; Meeting Abstract written in English. AN2005:1225093 CAPLUS (Copyright(C)2005 ACS on ScFinder (R))
  20. Gary L. Grunewald, Jian Lu, Kevin R. Criscione andCosmas O. Okoro, Inhibitors of phenylethanolamine N-methyltransferase devoid of α2–adrenoceptor affinity. Bioorganic & Medicinal Chemistry Letters 15 (2005) 5319-5323.
  21. Cosmas O. Okoro,Olugbeminiyi O. Fadeyi, Patrice L. Jackson, Rhonda L. Richmond, and Takeisha Farmer, Synthesis of fluorinated cyclic s-trans vinylogous acid and amide ester derivatives. Tetrahedron Letters 47 (2006) 7451-7454.
  22. Olugbeminiyi O. Fadeyi, andCosmas O. Okoro, “Synthesis and reactions of Fluorinated Cyclic s-Trans Vinylogous acids and Amides: Palladium-catalyzed coupling of fluorinated cyclic s-trans enaminone with aryl and heteroaromatic halides”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 88 (2006).
  23. Saudat T. Adamson, Olugbeminiyi O. Fadeyi, Elber L. Myles andCosmas O. Okoro, “The anticancer effects of some West African medicinal plants”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 89 (2006).
  24. Olugbeminiyi O. Fadeyi, Carolyn Cummings, Saudat T. Adamson,Cosmas O. Okoro, and E. Lewis Myles, “Isolation and characterization of the active components of Setaria Megaphylla”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 89 (2006).
  25. Fadeyi, Olugbeminiyi O.; Wash, Kendra;Okoro, Cosmas O. Synthesis of fluorinated dihydropyrazolo-pyrimidinederivatives as potential biologically active compounds. Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 (2007),MEDI-408. CODEN: 69JAUY AN 2007:295837 CAPLUS.


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