Prof. Amiram Goldblum
Molecular Modeling and Drug Design, Institute for Drug Discovery
University of Jerusalem, Israel
Email: Amiram@vms.huji.ac.il
Qualifications
1977 Ph.D., Organic Chemistry, Hebrew University, Jerusalem
1972 M.Sc., Theoretical Organic Chemistry, Hebrew University, Jerusalem
1970 B.Sc., Chemistry and Physics, Hebrew University, Jerusalem
Publications (selected)
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Cern A, Golbraikh, A, Sedykh, A, Tropsha A., Barenholz Y andGoldblum A.(2011) Quantitative Structure – Property Relationship Modeling of Remote Liposome Loading Of Drugs, J. Control.
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Dorman, G et al. (2010). Towards accelerated anti-cancer drug discovery: integration of chemoinformatics, cell-based screening and grid computing. Medicinal Chemistry Research 19, S14-S15
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Ursu, O, Rayan, A,Goldblum, Aand Oprea, T (2011). Understanding Drug Likeness. Wiley Interdisciplinary Reviews - Computational Molecular Science 1, 760-781
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Noy, E andGoldblum, A. (2010) Flexible protein-protein docking based on best-First search algorithm, J. Comput. Chem. 31, 1929-1943 (cover of journal)
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Rayan, A, Marcus, D andGoldblum, A. (2010) Predicting Oral Drug-Likeness by Iterative Stochastic Elimination, J. Chem. Inf. Model. 50, 437-445
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Lavy, T, Harries, D andGoldblum, A(2011) Molecular properties from conformational ensembles: I. dipole moments of molecules with multiple internal rotations, J Phys Chem A, 115, 5794-5809
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Zucker, D, Marcus, D, Barenholz, Y andGoldblum, A. (2009) Liposome Drugs’ loading efficiency: A working model based on loading conditions and drug’s physicochemical properties. J. Control. Release 139, 73-80
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Marcus, D, Rayan, A, Barasch, D, Elias, M andGoldblum, A. (2008) Learning from failures: Discontinued Compounds as a source for knowledge in drug discovery. Abs. Pap. Amer. Chem. Soc. 236, 67-CINF
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Marcus, D andGoldblum, A(2008) Molecular Selectivity Index for Ligand Based Drug Design, Abs. Pap. Amer. Chem. Soc. 235, 61-CINF
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Gorelik, B andGoldblum, A(2008) High quality binding modes in docking ligands to proteins, Proteins 71, 1 1373-1386
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Noy, E, Tabakman, T andGoldblum, A. (2007) Constructing ensembles of flexible fragments in native proteins by iterative stochastic elimination is relevant to protein-protein interfaces, Proteins 68, 702-711
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Ittah, S., Michaeli, A.,Goldblum, A. and Gat, U. (2007) A model for the structure of the C-terminal domain of dragline spider silk and the role of its conserved cysteine. Biomacromolecules 8: 2768-73
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Goldberg, M. andGoldblum, A. (2006) Computational protein design: a novel path to future protein drugs. Current Pharmaceutical Design 12, 3973-3997
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Rayan, A., Noy, E., Chema, D., Levitzki, A. andGoldblum, A. (2004).Stochastic algorithm for kinase homology model construction. Current Medicinal Chemistry 11, 675-692
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Rayan, A., Senderowitz, H. andGoldblum, A. (2004) Exploring the conformational space of cyclic peptides by a stochastic search method. Journal of Molecular Graphics and Modelling 22, 319-333
Profile Details
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