Biography

Prof. Thomas Moll

Adamis Pharmaceuticals Corporation, USA


Email: mollth@aol.com


Qualifications


1992 Ph.D., Univerity of Vienna, Biochemistry and Genetics


Publications(selected)

  1. L. Pon, T. Moll, D. Vestweber, B. Marshallsay and G. Schatz. (1989). Protein import into mitochondria: Demonstration of ATP-dependent translocation activity in a submitochondrial fraction enriched in membrane contact sites. J. Cell. Biol. 109, 2603-2616.T. Moll, G. Tebb, U. Surana, H. Robitsch and K. Nasmyth. (1991).The role of phosphorylation and the CDC28 protein kinase in cell cycle regulated nuclear import of the Saccharomyces cerevisiae transcription factor SWI5. Cell 66, 743-758.
  2. L. Dirick, T. Moll, H. Auer and K. Nasmyth. (1992). A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast. Nature 357, 508-513.
  3. SWI5 instability may be necessary but is not sufficient for asymmetric HO expression in yeast. Gen. Dev. 7, 517-528.
  4. T. Moll, E. Schwob, C. Koch, A. Moore, H. Auer and K. Nasmyth. (1993). Transcription factors important for starting the cell cycle in yeast. Phil. Trans. R. Soc. Lond. 340, 351-360.
  5. C. Koch, T. Moll, M. Neuberg, I. Maurer-Fogy and K. Nasmyth. (1993). A pair of transcription factors essential for entry into S phase in yeast. Science, 261, 1551-1557.
  6. Q. Cheng, C.A. Cant, T. Moll, R. Hofer-Warbinek, E. Wagner, M.L. Birnstiel, F.H. Bach and R. de Martin. (1994). NF-B subunit-specific regulation of the IĸBa promoter. J. Biol. Chem., 269, 13551-13557.
  7. T. Moll, M. Czyz, H. Holzmüller, R. Hofer-Warbinek, E. Wagner, H. Winkler, F.H. Bach and E. Hofer. (1995). Regulation of the Tissue Factor promoter in endothelial cells: Binding of NFĸB-, AP-1-, and Sp1-like transcription factors. J. Biol. Chem., 270, 3849-3857.
  8. C.J. Wrighton, R. Hofer-Warbinek, T. Moll, R. Eytner, F.H. Bach and R. de Martin. (1996). Inhibition of endothelial cell activation by adenovirus-mediated expression of IBa, an inhibitor of the transcription factor NF-B. J. Exp. Med., 183, 1013-1022.
  9. E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann and D. Vestweber. (1997). PSGL-1 on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med., 185, 573-578.
  10. E. Borges, R. Eytner, T. Moll, M. Steegmaier, M.A. Campbell, K. Ley, H. Mossmann and D. Vestweber. (1997). The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood, 90, 1934-1942.
  11. J.E. Blanks, T. Moll, R. Eytner and D. Vestweber. (1998). Stimulation of P-selectin glycoprotein ligand-1 on mouse neutrophils activates 2-integrin mediated cell attachment to ICAM-1. Eur. J. Immunol., 28, 433-438.
  12. T. Moll, E. Dejana and D. Vestweber. (1998). In vitro degradation of endothelial catenins by a neutrophil protease. J. Cell Biol., 140, 403-407.
  13. H. Holzmüller, T. Moll, R. Hofer-Warbinek, D. Mechtcheriakova, B.R. Binder, E. Hofer. (1999). Transcriptional repressor of the Tissue Factor gene in endothelial cells. Arterioscler. Thromb. Vasc. Biol., 19, 1804-1811.
  14. T. Moll (2000). Fas Ligand as an apoptosis-inducing regulator of leukocyte extravasation? Eur. Surg. Res., 32, 258.
  15. M.C. Huang, O. Zöllner, T. Moll, P. Maly, A.D. Thall, J.B. Lowe, D. Vestweber. (2000). P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases fuc-TIV and fuc-TVII in mouse neutrophils. J Biol Chem., 275, 31353-31360.
  16. M. Hammel, G. Weitz-Schmidt, A. Krause, T. Moll, D. Vestweber, H.G. Zerwes, R. Hallmann. (2001). Species-specific and conserved epitopes on mouse and human E-selection important for leukocyte adhesion. Exp. Cell Res., 269, 266-274.
  17. S. Ferrari-Lacraz, E. Zanelli, M. Neuberg, E. Donskoy, Y.S. Kim, X.X. Zheng, W. Hancock, W. Maslinski, X.C. Li, T.B. Strom, T. Moll. (2004). Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol., 173, 5818-5826.
  18. R.B. Moss, T. Moll, M. El-Kalay, C. Kohne, W. Soo Hoo, J. Encinas, D.J. Carlo. (2004). Th1/Th2 cells in inflammatory disease states : Therapeutic implications. Exp. Opin. Biol. Ther., 4, 1887-1896.
  19. M.-H. Prandini, I. Dreher, S. Bouillot, S. Benkerri, T. Moll, P. Huber. (2005). The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis. Oncogene, 24, 2992-3001.
  20. J.A. Encinas, E.M. Janssen, D.B. Weiner, S.A. Calarota, D. Nieto, T. Moll, D.J. Carlo, R.B. Moss. (2005). Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma. J. Allergy Clin. Immunol., 116, 1343-1349.
  21. X.X. Zheng, W. Gao, E. Donskoy, M. Neuberg, M. Ruediger, T.B. Strom, T. Moll. (2006). An antagonist mutant IL-15/Fc promotes transplant tolerance. Transplantation, 81, 109-116.
  22. W. SooHoo, E.R. Jensen, A. Saadat, D. Nieto, R.B. Moss, D.J. Carlo, T. Moll. (2006). Vaccination with T cell immunoglobulin mucin-1 antibodies and inactivated influenza enhances vaccine-specific lymphocyte proliferation, interferon-γ production, and cross-strain reactivity. Clin. Exp. Immunol., 145, 123-129.
  23. S. Ferrari-Lacraz, X.X. Zheng, A. Sanchez Fueyo, W. Maslinski, T. Moll, T.B. Strom. (2006). CD8+ T cells resistant to costimulatory blockade are controlled by an antagonist IL-15/Fc protein. Transplantation, 82, 1510-1517.
  24. S. Xiao, N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A.C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R.A. Sobel, D.T. Umetsu, H. Yagita, H. Akiba, T. Strom, M.H. Sayegh, R.H. DeKruyff, S.J. Khoury, V.K. Kuchroo. (2007). Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J. Exp. Med., 204, 1691-1702

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