Dr. Carmen Domene

Department of Chemistry

University of Oxford, UK

Email: carmen.domene@chem.ox.ac.uk

Qualifications

1998 Ph.D., University of Exeter, UK

1996 PGCE, University of Seville, Spain

1990 B.Sc., University of Seville, Spain

Publications (Selected)

1. Gating at the selectivity filter of ion channels that conduct Na+ and K+    ions. S. Furini, C. Domene, Biophys. J. J. 2011, 101, 1623-1631.
2. Selectivity and permeation of alkali ions through K+ channels. S. Furini, C. Domene, J. Mol. Biol. 2011, 409(5), 867-78.
3. Structural and biochemical analysis on the binding of acidic and basic substrates to ornithine acetyl transferase. A. Iqbal, D. Ivison, I. Clifton, R. Chowdhury, C. Domene, C. J. Schofield, Org. Biomol. Chem. 2011 9(18), 6219-25.
4. Polarization effects and selectivity in K+ channels. C. Illingworth, S. Furini, C. Domene, J. Chem. Theory Comput. 2010, 6, 3780–3792.
5. Chiral Phosphine-Phosphite with substituted ethane backbones; structural studies and application in catalytic asymmetric olefin hydrogenation. I. Arribas, S. Vargas, M. Rubio, A. Suárez, C. Domene, E. Álvarez, A. Pizzano, Organometallics 2010, 29, 5791–5804.
6. On ionic conduction in potassium channels. C. Domene, S. Furini, Proc. Natl. Acad. Sci. USA, 2010; 107:E128.
7. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1α. C. Illingworth, C. Loenarz, C. J. Schofield, C. Domene,Biochem, 2010 49(32), 6936-44.
8. Insights into the sliding movement of the transcription factor LacI on nonspecific DNA S. Furini, C. Domene, S. Cavalcanti, J. Phys. Chem. B, 2010, 114(6), 2238-45.
9. Atypical mechanism of conduction in potassium channels. S. Furini, C. Domene, Proc. Natl. Acad. Sci. USA, 2009, 106 (38) 16074-16077.
10. Computational studies on the interactions of inhalational anesthetics with proteins, S. Vemparala, C. Domene, M. L. Klein, Acc. Chem. Res. 2010, 43(1), 103-10.
11. Examining ion channels properties using free energy methods, C. Domene, S. Furini, Methods in Enzymology; Biothermodynamics, 2009, 466, 155-177.
12. Structural and mechanistic basis for hypoxia inducible factor hydroxylation by the oxygen sensing prolyl hydroxylases. R. Chowdhury, M. A. McDonough, J. Mecinovic, C. Loenarz, E. Flashman, K. S. Hewitson, C. Domene, J. Schofield, Structure, 2009, 17(7), 981-989.
13. Dynamics, energetics and selectivity of the low-K+ KcsA channel structure. Domene, S. Furini, J. Mol. Biol. 2009, 389, 637-45.
14. Many body effects and simulations of ion channels. C. Illingworth and C. Domene, Proc. R. Soc. A, 2009, 465, 1701-1716.
15. Permeation of water through the KcsA K+ channel. S. Furini, O. Beckstein, C. Domene, Proteins, 2009, 74 (2), 437-448.C. Domene (Oxford) 5
16. Anatomy of a simple acyl enzyme intermediate in enzyme catalysis-combined biophysical and modelling studies on ornithine acetyl transferase, A. Iqbal, I. J. Clifton, M. Bagonis, N. J. Kershaw, C. Domene, T.D.W. Claridge, C.W. Wharton, C.J. Schofield, J. Am. Chem. Soc. 2009, 131 (2) 749-57.
17. Conformational changes and gating at the selectivity filter of potassium channels. C. Domene, M. L. Klein, D. Branduardi, F. L. Gervasio, M. Parrinello, J. Am. Chem. Soc.2008, 130 (29) 9474-9480.
18. Model-based prediction of the α-hemolysin structure in the hexameric state. S. Furini, C. Domene, M. Rossi, M. Tartagni, S. Cavalcanti, Biophys. J. 2008, 95, 1-10.
19. Ion permeation in a potassium channel: computational studies of a closed and an open model. C. Domene, S. Vemparala, S. Furini, K Sharp, M. L. Klein, J. Am. Chem. Soc.,2008, 130 (11), 3389-3398.
20. Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis. S. Vemparala, C. Domene, M. L. Klein, Biophys J. 2008, 94 (11), 4260-11.
21. Molecular Dynamics Simulations of Potassium Channels. C. Domene, Central European J. Chem. 2007, 5 (3) 635-671