Dr.
Jonathan R. Keller
Center For Cancer Research
National Cancer Institute-NIH, USA
Email: kellerjo@mail.nih.gov
Qualifications
1981-1985 Ph.D.,
George Washington University, USA
1974-1978 B.Sc.,
University of Maryland, College Park, USA
Publications(Selected)
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Suh H. C., Gooya J.,
Renn K., Friedman A. D., Johnson P. F. and Keller J. R.: C/EBPα determines
hematopoietic cell fate in multipotential progenitor cells by inhibiting
erythroid differentiation and inducing myeloid differentiation. Blood 107: 4308
– 4316, 2006.
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Berthet C.,
Klarmann K. D., Hilton M. B., Suh H. C., Keller J. R., Kiyokawa H., Kaldis P.: Combined
Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb
Hypophosphorylation. Dev. Cell 10: 563-573, 2006.
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Aiello F. B., Keller
J. R., Klarmann K. D., Dranoff G., Mazzucchelli R., Durum S. K.: IL-7 Induces Myelopoiesis and Erythropoiesis.
J. Immunology 78: 1553-1563, 2007.
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Jiang Q., Huang J.,
Li W., Cavinato T., Keller J. R., and Durum S. K.: Role of the intracellular
domain of IL-7 receptor in T cell development. J. Immunology 178: 228-232, 2007.
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Gudmundsson K. O.,
Thorsteinsson L., Sigurjonsson O. E., Keller J. R., Olafsson K., Egeland T.,
Gudmundsson S. and Rafnar T.: Dlg7, the homologue of the Drosophilia Dlg1 tumor
suppressor gene, has a role in stem cell survival and in maintaining stem cell
properties. Stem Cells 25: 1498-1506, 2007.
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Berthet C.,
Rodriguez-Galan M. C., Hodge D. L., Gooya J., Pascal V., Young H. A., Keller J.
R., Bosselut R., and Kaldis P.: Hematopoiesis and thymic apoptosis are not
affected by the loss of Cdk2. Molec. Cell. Bio. 27(14): 5079-5089, 2007.
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Ludlow L. E.,
Purton L. E., Klarmann K., Gough H. L. L., Trapani J. A., Keller J. R., Clarke
C. J. P., Johnstone R. W.: The role of p202 in regulating hematopoietic cell
proliferation and differentiation. J. Interferon & Cytokine Res. 28: 5-11,
2008.
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Fan T., Schmidtmann
A., Zhu H., Suh H. C., Gooya J., Keller J. R., Xi S., Hong X., Roayaei J., Anver
M., Ruscetti S., and Muegge K.: DNA hypomethylation caused by Lsh deletion
promotes erythroleukemia development. Epigenetics 3(3): 134-42, 2008.
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Ji M., Li H., Suh H.
C., Klarmann K. D., Yokota Y., and Keller J. R.: Id2 regulates lymphoid and
erythroid development via interaction with different target proteins. Blood
112(4): 1068-77, 2008.
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Cohen T. V.,
Klarmann K. D., Sakchaisri K., Kuhns D., Anver M., Johnson P. F., Williams S.,
Johnson P., Keller J. R., Stewart C. L.: The Lamin B receptor under the
transcriptional control of C/EBP-epsilon is required for morphological but not
functional maturation of neutrophils. Hum. Mol. Genet. 17(19): 2921-33, 2008.
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Suh H. C.,
Leeanansaksiri W., Ji M., Klarmann K. D., Renn K., Gooya J., Smith B. D.,
McNiece I., Lugthart S., Valk P., Delwel R., and Keller J. R.: Id1 Immortalizes
hematopoietic progenitors in vitro and promotes a myeloproliferative disease in
vivo. Oncogene 27: 5612-23, 2008.
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Suh H. C., Ji M.,
Gooya J., Lee M., Klarmann K. D., Keller J. R.: Cell-nonautonomous function of
Id1 in the hematopoietic progenitor cell niche. Blood 114(6): 1186-1195, 2009.
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Li H., Ji M.,
Klarmann K. D., Keller J. R.: Repression of Id2 expression by Gfi-1 is required
for B-cell and myeloid development. Blood 116(7): 1060-1069, 2010.
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Klarmann K., Ji M.,
Li H., Satyanarayana A., Kim W., Bowers E., Gudmundsdottir B., Keller J. R.:
Novel Targets in Myelogenous Leukemia: The Id Family of Proteins. In Tech – Myeloid
Leukemia – Basic Mechanisms of Leukemogenesis, Chapter 12: 215-238, 2011.
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Satyanarayana A.,
Klarmann K., Gavrilova O., Keller J. R.: Ablation of the transcriptional
regulator Id1 enhances energy expenditure, increases insulin sensitivity and
protects against age and diet induced insulin resistance and hepatosteatosis. FASEB
J. 26(1): 309-323, 2011.
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Satyanarayana A.,
Gudmundsson K. O., Chen X., Coppola V., Tessarollo L., Keller J. R.*, Hou S. X.:
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult
hematopoiesis. *Corresponding author. Blood 116(16): 2921-2931, 2011.
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Gudmundsson K. O.,
Stull S. W., Keller J. R.: Transplantation of mouse fetal liver cells for
analyzing the function of hematopoietic stem and progenitor cells. Methods Mol.
Biol. 879: 123-133, 2012.
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Oakley K., Han Y.,
Vishwakarma B., Bhatia R., Gudmundsson K., Keller J. R., Vasko V., Jenkins N. A.,
Copeland N. G., and Yang Du: Setbp1 promotes the self-renewal of myeloid
progenitors via activation of Hoxa9 and Hoxa10. Blood 119(25): 6099-6108, 2012.
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Baba M., Keller J. R.,
Sun H. W., Resch W., Kuchen S., Suh H. C., Hasumi H., Hasumi Y., Kieffer-Kwon K.
R., Gonzalez C. G., Hughes R. M., Klein M. E., Oh H. F., Bible P., Southon E.,
Tessarollo L., Schmidt L. S., Linehan W. M., and Casellas R.: The
folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for
murine B-cell development. Blood 120(6): 1254-61, 2012.
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Balamurugan K.,
Sharan S., Klarmann K. D., Zhang Y., Coppola V., Summers G. H., Roger T.,
Morrison D. K., Keller J. R., Sterneck E.: FBXW7α attenuates inflammatory
signaling by downregulating C/EBPδ and its target gene Tlr4. Nat. Commun. 4:
1662, 2013.
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Singh, S. K.,
Williams C. A., Klarmann K. D., Keller J. R., and Philipp Oberdoerffer. Sirt1
ablation promotes stress-induced loss of genetic and epigenetic hematopoietic
stem cell maintenance. Journal Exp. Med. 210(5):987-1001, 2013.
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Aiello, F. B.,
Graciotti L., Procopio A. D., Keller J. R., Durum S. K. Stemness of T cells and
the hematopoietic stem cells: fate, memory, niche, cytokines. Cytokine Growth
Factor Review. 24(6): 485-501, 2013.
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Sun L., Mathews L. A.,
Cabarcas S. M., Zhang X., Yang A., Zhang Y., Young M. R., Klarmann K. D., Keller
J. R., Farrar W. L.: Epigenetic Regulation of SOX9 by the NF-κB Signaling
Pathway in Pancreatic Cancer Stem Cells. Stem Cells, Aug; 31(8), p1454-66, 2013.
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Kim W-I, Klarmann
K. D., Keller J. R., Gfi-1 regulates the erythroid transcription factor network
through Id2 repression in hematopoietic progenitor cells. Blood, 124 (10), p1586-96,
2014.
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Fan-ching L., Bahara
S., Hodge D. L., Boelte K., Keller J.R.*, Young H. A., IFN-gamma causes
aplastic anemia by altering HSC composition and interrupting lineage
differentiation. *Corresponding Author. Blood 124 (25), p3699-3708, 2014.