Prof. Xuebin Qin

Laboratory for Translational Research

Harvard Medical School, USA

Email: xuebin_qin@hms.harvard.edu

Qualifications

Publications(Selected)

1. Gao H, Boustany RM, Espinola JA, Cotman SL, Srinidhi L, Antonellis KA, Gillis T, Qin X, Liu S, Donahue LR, Bronson RT, Faust JR, Stout D, Haines JL, Lerner TJ, MacDonald ME. Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. American Journal of Human Genetics. 2002;70:324-335.
2. Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, Halperin JA. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003;18:217-227.
3. Acosta J, Qin X, Halperin JA. Complement and complement regulatory proteins as potential molecular targets for vascular diseases. Current Pharmaceutical Design. 2004;10:203-211.
4. Qin X, Goldfine A, Krumrei N,Grubissich L, Acosta J, Chorev M, Hays AP, Halperin JA. Glycation-inactivation of the complement regulatory protein CD59: A possible role in the pathogenesis of the vascular complications of human disease. Diabetes. 2004;53:2653-2661.
5. Qin X, Ferris X, Dobarro M, Grubissich J, and Halperin JA. Toward the generation of mouse models for studying the pathogenesis of complement mediated human diseases. Immunology 2004. 2004: pp. 63-67.
6. Qin X, Dobarro M, Bedford SJ, Ferris S, Miranda PV, Bronson RT, Visconti PE, & Halperin JA. Further characterization of the reproductive abnormalities in mCd59b knockout mice: A potential new function of mCd59 in male reproduction. Journal of Immunolgy. 2005;175(10):6294-9302.
7. Qin X, Ferris X, Hu W, Feng G, Ziegeler G, and Halperin JA. Analysis of the Promoters and 5’-UTR of Mouse Cd59 Genes, and of their Functional Activity in Erythrocytes. Genes and Immunity. 2006;7(4):287-297.
8. Qin X, Gao B. The complement system in liver diseases. Cell Mol Immunol. 2006;3(6):333-340.
9. Hu W, Ferris S, Tweten RK, Wu G, Bronson RT, Halperin JA and Qin X. Conditional, rapid and targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nature Medicine. 2008;14:98-103.
10. Zhou X, Hu W, and Qin X. The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy. The Oncologist. 2008;13(9):854-966.
11. Qin X, Hu W, Song W, Grubissich L, Hu X, Wu G, Ferris S, Dobarro M, and Halperin JA. Generation and phenotyping of a mCd59a and mCd59b double-knockout mice. American Journal of Hematology. 2008;84:65-70.
12. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. The balancing role of nitric oxide in complement-mediated platelet activation of mCd59a and mCd59b double-knockout mice. American Journal of Hematology. 2009;84(4):221-227
13. Pan H, Shen Z, Mukhopadhyay P, Wang H, Pacher P, Qin X, Gao B. Anaphylatoxin C5a Contributes to the Pathogenesis of Cisplatin-induced Nephrotoxicity. Am J Physiol Renal Physiol. 2009;296(3):F496-504
14. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X. Complement Regulator CD59 Protects Against Atherosclerosis by Restricting the Formation of Complement Membrane Attack Complex. Circulation Research. 2009; 104(4):550-558
15. Tang H, Lu D, Pan R, Qin X, Xiong H, Dong J. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sciences. 2009, 85(1-2), 1-10
16. Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, Shiramizu B, Halperin JA, Qin X. A High-Affinity Inhibitor of Human CD59 Enhances Complement-Mediated Virolysis of HIV-1: Implications for Treatment of HIV-1/AIDS.J Immunol. 2010:184(1):359-68.
17. Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010:121:1338-1346.
18. Yu Q, Yu R, Qin X. The good and evil of complement activation in HIV-1 infection. Cell Mol Immunol. 2010 Sep; 7(5):334-40.
19. Gurdrun Z, Ming J, Jane CJ, Sema S, Chen T, Qin X, Aktas H. ELAV like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin dependent kinase inhibitor p27KIP1. Journal of Biological Chemistry. 2010, 285(20):15408-19.
20. Hu W, Jin R, Zhang J, You T,Peng Z, Bronson RT, Halperin JA, Loscalzo J, Qin X. The Critical Roles of Platelet Activation and Reduced NO Bioavailability in Fatal Pulmonary Arterial Hypertension in a Murine Hemolysis Model. Blood, 2010 Sep 2;116(9):1613-22.
21. You T, Hu W, Ge X, Shen J, Qin X. Application of a novel inhibitor of human CD59 for the enhancement of complement-dependent cytolysis on cancer cells. Cell Mol Immunol. 2011, Mar; 8(2): 157-63. PMID: 21258360.
22. Hu X, Ge X, YouX, XuT, Zhang J, WuG, Peng Z, ChorevM, AktasH, HalperinJA, BrownJ, QinX. Human CD59 inhibitor sensitizes rituximab resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011 Mar 15; 71(6):2298-307. PMID: 21252115
23. Sun H, Li M, Lu J, Yan D, Zhou C, Fan J, Qin X, Tang H, Peng Z. Overexpression of Forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma. Oncol Rep. 2011 Jun;25(6):1533-9.
24. Sun H, Teng M, Liu J, Jin D, Wu J, Yan D, Fan J, Qin X, Tang H, Peng Z. FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria. Cancer Lett. 2011 Apr 9. [Epub ahead of print]
25. Ge X, Wu L, Hu W, Fernandes S, Wang C, Li X, Brown JR, Qin X. rILYd4, a Human CD59 Inhibitor Enhances Complement Dependent Cytotoxicity of Ofatumumab against Rituximab-resistant B-cell Lymphoma Cells and Chronic Lymphocytic Leukemia. Clin Cancer Res. 2011 Sep 14. [Epub ahead of print]. PMID: 21918174 (Highlighted paper)
26. Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He J. and Yu Q. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 19 SEP 2011 09:08AM EST. [Epub ahead of print].
27. Zhang J, Hu W, Xing W, You T, Xu, J, Qin, X, Peng Z. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. American Journal of Pathology, 2011, 21 SEP. [Epub ahead of print].