Biography

Dr. Yue Chen
University of Pittsburgh, USA 

Email: CHENY@pitt.edu

Qualifications


1992-1998    Ph.D., University of Pittsburgh, USA
1986-1989    M.S., Xian Medical University, China
1978-1983    M.D., Dalian Medical University, China

Publications
  1. Pegu P, Helmus R, Gupta P, Tarwater P, Caruso L, Shen C, Ross T, Yue Chen. Induction of Strong Anti-HIV Cellular Immunity by a Combination of Clostridium Perfringens Expressing HIV Gag and Virus Like Particles. Curr HIV Res. 2011 (available online).
  2. Biswas N, Wang T, Ding M, Tumne A, Chen Y, Wang Q, Gupta P. ADAR1 is a novel multi targeted anti-HIV-1 cellular protein. Virology 2011 (available online)
  3. Shen C, Craigo JL, Ding M, Chen Y, Gupta P. Origin and dynamics of HIV-1 subtype C infection in India. PloS One 2011;6(10):e25956.
  4. Ding M, Bullotta A, Caruso L, Gupta P, Rinaldo R, Chen Y. An optimized sensitive method for quantitation of DNA/RNA viruses in heparinized and cryopreserved plasma. Journal of Virological Methods 2011 Sep; 176(1-2):1-8.
  5. Shen C, Ding M, Craigo JK, Tarwater P, Chatterjee R, Roy P, Guha SK, Saha B, Modak D, Neogi D, Chen Y, Gupta P. Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments. Virology 2010 Jun 5;401(2):190-6.
  6. Helmus RA, Poonam P, Caruso L, Gupta P, Chen Y. Induction of SIV p27-specific multifunctional T Cells in the gut following prime-boost immunization with Clostridium perfringens and adenovirus vaccines expressing SIV-p27. Curr HIV Res. 2010 Mar 1:8(2):101-12.
  7. Chakrabarti AK, Caruso L, Ding M, Shen C, Buchanan W, Gupta P, Rinaldo CR, Chen Y. Detection of HIV-1 RNA/DNA and CD4 mRNA in feces and urine from chronic HIV-1 infected subjects with and without anti-retroviral therapy. AIDS Res Ther. 2009 Oct 2;6:20.
  8. Chen Y, Shen C, Wu H, Caruso L, Ratner D, Rodriguez M, Chen X, Gupta P. Biological Properties of HIV-1 subtype B’ isolates from infected Chinese blood donors at different disease stages. Virology 2009 Feb 5;384(1):161-8.
  9. Tumne A, Shridhar V, Chen Y, Stolz D, Saha K, Ratner D, Ding M, Watkins S, and Gupta P. Noncytotoxic Suppression of HIV-1Transcription by Exosomes Secreted from CD8+ T Cells. J Virol. 2009 May;83(9):4354-64.
  10. Rodriguez MA, Ding M, Ratner D, Chen Y, Tripathy SP, Kulkarni SS, Chatterjee R, Tarwater PM, Gupta P. High replication fitness and transmission efficiency of HIV-1 subtype C from India: Implications for subtype C predominance. Virology. 2009 Mar 15;385(2):416-24.
  11. Ding M, Tarwater P, Rodriguez M, Chatterjee R, Ratner D, Yamamura Y, Roy P, Mellors J, Neogi D, Chen Y, Gupta P. Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India. J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):119-25.
  12. Shen C, Gupta P, Wu H, Chen X, Huang X, Zhou Y, Chen Y. Molecular characterization of the HIV type 1 vpr gene in infected Chinese former blood/plasma donors at different stages of diseases. AIDS Res Hum Retroviruses. 2008 Apr;24(4):661-6.
  13. Sayeed S, Uzal FA, Fisher DJ, Saputo J, Vidal JE, Chen Y, Gupta P, Rood JI, McClane BA. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.
  14. Mol Microbiol. 2008 Jan;67(1):15-30.
  15. Gupta P, Chen Y. Chromosomal engineering of Clostridium perfringens using group II introns. Methods Mol Biol. 2008; 435:217-28.
  16. Chen Y, Caruso L, Shen C, Wu H, Zhou Y, Gupta P. Lack of differences in HIV-1 nef functional domains in infected chinese blood donors at different stages of disease. AIDS Res Hum Retroviruses. 2007 Sep;23(9):1150-4.
  17. Chen Y, Caruso L, McClane B, Fisher D, Gupta P. Disruption of a toxin gene by introduction of a foreign gene into the chromosome of Clostridium perfringens using targetron-induced mutagenesis. Plasmid. 2007 Sep;58(2):182-9.
  18. Yue Chen, Jodi K. Craigo, Ming Ding, Yan Guo, Shengli Shen, Yushen Zhou, Hao Wu, Phalguni Gupta. Characterization of the gp120 of Circulating HIV Type 1 in a Group of Infected Chinese Blood/Plasma Donors with Asymptomatic and Symptomatic Stages of the Disease. Aids Research And Human Retroviruses 2006 22:1167–1171.
  19. Milka Rodriguez, Yue Chen, Jodi Craigo, Ramdas Chatterjee, Deena Ratner, Masashi Tatsumi, Pratima Roy, Dhruba Neogi and Phalguni Gupta. Construction and characterization of a full length infectious molecular clone of subtype A HIV-1 from India. Virology, 2006 345, 328-336.
  20. Yue Chen, Bruce McClean, Derek Fisher, Julian Rood and Phalguni Gupta. Construction of an alpha toxin gene inactivated mutant of clostridia perfringens type A using a moblile II group II intron. Journal of Applied environmental Microbiology, 2005 71, 7542-7547.
  21. Yue Chen, Ruth Helmus, Bruce McClane, Rosemary Hoffman, Simon Watkins, Tom Wehrli, and Phalguni Gupta. Use of a Clostridium Perfringens vector to express high levels of SIV p27 protein for the development of an oral SIV vaccine. Virology, 2004 329, 226-233.
  22. Yue Chen, Ala Stanford, Richard Simmons, Henri Ford and Rosemary Hoffman. Nitric oxide protects thymocytes from -irradiation-induced apoptosigs in correlation with inhibition of p53 upregulation and mitochondrial damage. Cellular Immunology 2001, 214, 72-80
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