Dr. Zvi Kelman

University of Maryland, USA

Email: zkelman@umd.edu

Qualifications

1996  Ph.D., Sloan-Kettering Cancer Center, USA

1989  M.Sc., The Weizmann Institute of Science, Israel

1987  B.Sc., The Hebrew University of Jerusalem, Israel

Publications (selected)

1. Ladner, J. E., Pan, M., Hurwitz, J. and Kelman, Z. (2011). Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis. Proc. Natl. Acad. Sci. USA, 108, 2711-2716.
2. Pan, M., Kelman, L. M. and Kelman, Z. (2011). The archaeal PCNA proteins. Biochem. Soc. Trans. 39, 20-24.
3. Sakakibara, N., Kasiviswanathan, R. and Kelman, Z. (2011). Mutational analysis of conserved aspartic acid residues in the Methanothermobacter thermautotrophicus MCM helicase.  Extremophile, 15, 245-252.
4. Chen, C., Gorlatova, N., Kelman, Z. and Herzberg, O. (2011). Structures of p63 DNA binding domain in complexes with two different A/T rich response elements reveal DNA super helices. Proc. Natl. Acad. Sci. USA, 108, 6456-6461.
5. Chen, Y., Apolinario, E., Brachova, L., Kelman, Z., Li, Z., Nikolau, B. J., Showman, L., Sowers, K. and Orban, J. (2011). A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans. BMC Genomics 12, S7.
6. Li, Z., Pan, M., Santangelo, T.J., Chemnitz, W., Yuan, W., Edwards, J.L., Hurwitz, J., Reeve, J.N. and Kelman, Z. (2011). A novel DNA nuclease is stimulated by association with the GINS complex. Nucleic Acids Res. 39, 6114–6123.
7. Pan, M., Santangelo, T.J., Li, Z., Reeve, J.N. and Kelman, Z. (2011). Thermococcus kodakarensis encodes three MCM homologues but only one is essential. Nucleic Acids Res. In press.
8. Lee, C., Liachko, I., Bouten, R., Kelman, Z. and Tye, B.K. (2010). Alternative mechanisms for coordinating polymerase a and MCM helicase. Mol. Cell. Biol. 30, 423-435.
9. Kelman, L.M. and Kelman, Z. (2010). Cell cycle regulated genes in the three domains of life. Cell Cycle 9, 863-864.
10. Wang, X., Kelman, Z. and Culver, J.N. (2010) Helicase ATPase activity of the Tobacco mosaic virus 126-kDa protein modulates replicase complex assembly. Virology 402, 292-302.
11. Carmel, R., Bellevue, R. and Kelman, Z (2010). Low cobalamin levels associated with sickle cell disease: contrasting origins and clinical meanings in two instructive patients. Amer. J. Haematol. 85, 436-439.
12. Li, Z., Santangelo, T.J., Čuboňová, L., Reeve, J.N. and Kelman, Z. (2010). Affinity purification of an archaeal DNA replication protein network. MBio 1, e00221-10.
13. Sakakibara, N., Kasiviswanathan, R. and Kelman, Z. (2010). Different residues on the surface of the Methanothermobacter thermautotrophicus MCM helicase interact with single and double stranded DNA. Archaea Article ID 505693.
14. Fatscher, T. (2010). An internship experience annotating poorly understood genes in Methanosarcina acetivorans. BIOS 81, 105–107.
15. Shin, J.-H., Heo, G.-Y. and Kelman, Z. (2009). The Methanothermobacter thermautotrophicus MCM helicase is active as a hexameric ring. J. Biol. Chem. 284, 540-546.
16. Haugland, G.T., Rollor, C.R. Birkeland, N.-K. and Kelman, Z. (2009). Biochemical characterization of the minichromosome maintenance (MCM) protein from the archaeon Thermoplasma acidophilum. Extremophiles 13, 81-88.
17. Sakakibara, N., Kelman, L.M. and Kelman, Z. (2009). How is the archaeal MCM helicase assembled at the origin? Possible mechanisms. Biochem Soc Trans. 37, 7-11.
18. Sakakibara, N., Schwarz, F.P. and Kelman, Z. (2009). ATP hydrolysis and DNA binding confer thermostability on the MCM helicase. Biochemistry 48, 2330-2339.
19. Sakakibara, N., Kelman, L.M. and Kelman, Z. (2009). Unwinding the structure and function of the archaeal MCM helicase. Mol. Microbiol. 72, 286-296.
20. Samuels, M., Gulati, G., Shin, J.-H., Opara, R., McSweeney, E., Kirkland, N., Sekedat, M., Long, S., Kelman, Z. and Jeruzalmi, D. (2009). A biochemically active MCM-like helicase in Bacillus cereus. Nucleic Acids Res. 37, 4441-4452.