Dr. Sheng-He Huang

Keck School of Medicine

University of Southern California (USC), Los Angeles, USA

Associate Professor

Email: shhuang@hsc.usc.edu

Qualifications

1986–1989 Postdoctoralfellow, Children’s Hospital Los Angeles, USC, USA

1978–1981 M.D., Institute of Basic Med. Sci., Chinese Academy of Medical Sciences (CAMS)/Peking Union Medical College (PUMC), Beijing, China

1970-1973 B.S,The First Medical University of the PLA (Southern Medical University), Guangzhou, China

1. Huang SH, Wu CH, Jiang SB, Bahner I, Lossinksy AS, Jong A. (2011) HIV-1 gp41 ectodomain enhancesC. neoformansbinding to human brain microvascular endothelial cells via gp41 core-induced membrane activities.Biochemical J.438:457-66, 2011.
2. Huang SH, Long M, Wu CH, Kwon-Chung KJ, Chang YC, Chi F, Lee S, Jong A. Invasion ofcryptococcus neoformansinto human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway viadual specificity tyrosine-phosphorylation-regulated kinase 3(dyrk3).J Biol Chem. 286:34761-9, 2011.
3. Che X, Chi F, Wang L, Jong TD, Wu CH, Wang X, Huang SH.Involvement of IbeA in meningiticEscherichia coliK1-induced polymorphonuclear leukocyte transmigration across brain endothelial cells.Brain Pathol21:389-404, 2011.
4. Chi F, Jong T, Wang L, Ouyang Y, Wu C, Li W, Huang SH.Vimentin-mediated signaling is required for IbeA+E. coliK1 invasion of human brain microvascular endothelial cells.Biochem J. 427:79-90, 2010.
5. Jong A, Wu CH, Prasadarao, NV, Kwon-Chung J, Chang Y, Chen HM, Ouyang Y, Shackleford GM, Huang SH. Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-alpha activation.Cell Microbiol10:1854-65, 2008.
6. Huang SH, Triche T, Jong AY.Infectomics: genomics and proteomics of microbial infections.Funct. Integr. Genomics. 1:331-44, 2002.
7. Huang, S.H., Wan, Z.S., Chen, Y.H, Jong, A.Y., andKim, K.S. Further characterization ofEscherichia colibrain endothelial cell invasion geneibeAby deletion, complementation andprotein expression.J. Infect. Dis. 183:1071-8, 2001.
8. Huang, S.H., Wass, C.A., Fu, Q., Prasadarao, N.A., Stins, M.F., and Kim, K.S.: Escherichia coli invasion of brain microvascular endothelial cells in vitro andin vivo: molecular cloning and characterization of invasion gene ibe10,Infect. Immun.63:4470-4475, 1995.
9. Huang,S.H., and Jong, A.: Efficient Induction and preparation of fusion proteins from recombinant lambda gt11 clones.Trends in Genetics, 10:183, 1994.

Books:

1. Callaos N, Lesso W, Zinn CD, Tominaga D, Hashimoto S, Huang SH, Truta M. Proceedings of WMSCI 2007, Volume IV,Orlando, Florida, USA
2. Huang SH. and Ma J.J.: Clinical Enzymology, Scientific and Technical Press, Tianjin, China, 1984

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