Biography

Prof. Juan Sastre

Physiology, University of Valencia, Spain

Full Professor


Email:
Juan.Sastre@uv.es

 

Qualifications

1989   Ph.D., Pharmacy, University of Valencia, Spain

1986   B.S., Pharmacy at the University of Valencia, Spain

 

Publications

  1. Sastre J, Serviddio G, Pereda J, Minana JB, Arduini A, Vendemiale G, Poli G, Pallardo FV, Viña J. Mitochondrial function in liver disease. Front Biosci. 2007;12:1200-9.  
  2. Garcia-de-la-Asuncion J, Gomez-Cambronero LG, Del Olmo ML, Pallardo FV, Sastre J, Vina J. Vitamins C and E prevent AZT-induced leukopenia and loss of cellularity in bone marrow. Studies in mice. Free Radic Res. 2007;41(3):330-4. 
  3. Rodriguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, Garcia-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, Lopez-Rodas G.Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. Int J Biochem Cell Biol. 2007;39(4):842-50.  
  4. García de la Asuncion J, Belda FJ, Greif R, Barber G, Vina J, Sastre J. Inspired supplemental oxygen reduces markers of oxidative stress during elective colon surgery. Br J Surg. 2007;94(4):475-7. 
  5. Lloret A, Buj J, Badía MC, Sastre J, Morera J, Viña J.Obstructive sleep apnea: arterial oxygen desaturation coincides with increases in systemic oxidative stress markers measured with continuous monitoring. Free Radic Biol Med. 2007;42(6):893-4. 
  6. Markovic J, Borras C, Ortega A, Sastre J, Vina J, Pallardo FV. Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem. 2007;282(28):20416-24.  
  7. Martín JA, Pereda J, Martínez-López I, Escrig R, Miralles V, Pallardó FV, Viña JR, Vento M, Viña J, Sastre J. Oxidative stress as a signal to up-regulate gamma-cystathionase in the fetal-to-neonatal transition in rats. Cell Mol Biol 2007;53 Suppl:OL1010-7. 
  8. Aranda R, Doménech E, Rus AD, Real JT, Sastre J, Viña J, Pallardó FV. Age-related increase in xanthine oxidase activity in human plasma and rat tissues. Free Radic Res. 2007;41(11):1195-200. 
  9. Casado D, Sabater L, Calvete J, Mayordomo E, Aparisi L, Sastre J, Lledo S. Multiple intrahepatic pseudocysts in acute pancreatitis. World J Gastroenterol. 2007;13(34):4655-7. 
  10. Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J, Alonso MD. Mitochondrial oxidant signalling in Alzheimer's disease. J Alzheimers Dis. 2007;11(2):175-81.  
  11. Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J, Alonso MD. Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide. Antioxid Redox Signal. 2007;9(10):1677-90. 
  12. Viña J, Sastre J, Pallardó FV, Gambini J, Borrás C. Modulation of longevity-associated genes by estrogens or phytoestrogens. Biol Chem. 2008 Mar;389(3):273-7. 
  13. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Viña J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008;87(1):142-9.
  14. Serviddio G, Sastre J, Bellanti F, Viña J, Vendemiale G, Altomare E. Mitochondrial involvement in non-alcoholic steatohepatitis. Mol Aspects Med. 2008;29(1-2):22-35.  
  15. Lopez-Gines C, Gil-Benso R, Benito R, Mata M, Pereda J, Sastre J, Roldan P, Gonzalez-Darder J, Cerdá-Nicolás M. The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFRamplification. Neuropathology. 2008; 28(5):507-15.
  16. Vallés SL, Borrás C, Gambini J, Furriol J, Ortega A, Sastre J, Pallardó FV, Viña J. Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell. 2008;7(1):112-8.  
  17. Serviddio G, Bellanti F, Tamborra R, Rollo T, Capitanio N, Romano AD, Sastre J, Vendemiale G, Altomare E. UCP2 induces mitochondrial proton leak and increases susceptibility of NASH liver to ischemia/reperfusion injury. Gut. 2008; 57(7):957-65. 
  18. Pereda J, Escobar J, Sandoval J, Rodríguez JL, Sabater L, Pallardó FV, Torres L, Franco L, Viña J, López-Rodas G, Sastre J. Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis. Free Radic Biol Med. 2008; 44(8):1599-609. 
  19. Aparisi L, Sabater L, Del-Olmo J, Sastre J, Serra MA, Campello R, Bautista D, Wassel A, Rodrigo JM. Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects? World J Gastroenterol. 2008;14(40):6171-9. 
  20. Ledo A, Arduini A, Asensi MA, Sastre J, Escrig R, Brugada M, Aguar M, Saenz P,Vento M. Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants. Am J Clin Nutr. 2009;89(1):210-5.  
  21. Escobar J, Pereda J, Sandoval J, Sabater L, Aparisi L, Lopez-Rodas G, Sastre J. (2009) Cross-talk between oxidative stress and proinflammatory cytokines in acute pancreatitis: a key role for protein phosphatases. Curr. Pharm. Des.  15(26):3027-42. 
  22. Sandoval J, Escobar J, Pereda J, Sacilotto N, Rodriguez JL, Sabater L, Aparisi L, Franco L, Lopez-Rodas G, Sastre J. Pentoxifylline prevents loss of PP2A phosphatase activity and recruitment of histone acetyltransferases to pro-inflammatory genes in acute pancreatitis. J Pharmacol Exp Ther. 2009; 331: 609-617. 
  23. Vento M, Aguar M, Escobar J, Arduini A, Escrig R, Brugada M, Izquierdo I, Asensi MA, Sastre J, Saenz P, Gimeno A. Antenatal steroids and antioxidant enzyme activity in preterm infants: influence of gender and timing. Antioxid Redox Signal. 2009;11(12):2945-55.  
  24. Vento M, Moro M, Escrig R, Arruza L, Villar G, Izquierdo I, Roberts LJ 2nd, Arduini A, Escobar JJ, Sastre J, Asensi MA. Preterm Resuscitation With Low Oxygen Causes Less Oxidative Stress, Inflammation, and Chronic Lung Disease. Pediatrics. 2009;124(3):e439-49.  
  25. Sandoval J, Pereda J, Rodriguez JL, Escobar J, Hidalgo J, Joosten LA, Franco L, Sastre J, López-Rodas G. Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis. Cell Mol Life Sci. 2010; 67(10):1687-97. 
  26. Escobar J, Pereda J, Arduini A, Sandoval J, Sabater L, Aparisi L, Vento M, López-Rodas G, Sastre J. Role of redox signaling, protein phosphatases and histone acetylation in the inflammatory cascade in acute pancreatitis. Therapeutic implications. Inflammation & Allergy – Drug Targets 2010; 9(2):97-108.
  27. Caro P, Gómez J, Arduini A, González-Sánchez M, González-García M, Borrás C, Viña J, Puertas MJ, Sastre J, Barja G. Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age. Mitochondrion. 2010;10(5):479-86. 
  28. Romagnoli M, Gomez-Cabrera MC, Perrelli MG, Biasi F, Pallardó FV, Sastre J, Poli G, Viña J. Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Free Radical Biol Med. 2010; 49(2):171-7. 
  29. Serviddio G, Bellanti F, Sastre J, Vendemiale G, Altomare E. Targeting mitochondria: a new promising approach for the treatment of liver diseases. Curr Med Chem. 2010;17(22):2325-37. 
  30. Escobar J, Pereda J, Arduini A, Sandoval J, Sabater L, Aparisi L, López-Rodas G, Sastre J. Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis. World J Gastrointest. Pharmacol. Ther. 2010; 1(3): 75-80 
  31. Serviddio G, Sastre J. Measurement of mitochondrial membrane potential and proton leak. Methods Mol Biol. 2010;594:107-21. 
  32. Arduini A, Serviddio G, Escobar J, Tormos AM, Bellanti F, Vina J, Monsalve M, Sastre J. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Am J Physiol Gastrointest Liver Physiol. 2011; 301(1):G119-27.  
  33. Escobar J, Pereda J, Arduini A, Sandoval J, Moreno ML, Pérez S, Sabater L, Aparisi L, Cassinello N, Hidalgo J, Joosten L.A.B., Vento M, López-Rodas G, Sastre J. Oxidative and nitrosative stess in acute pancreatitis. Modulation by pentoxifylline and oxypurinol. Biochem. Pharmacol. (In press). 

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