Prof. Pablo Iván Nikel

Institute for Research in Biotechnology

University of San Martín, Argentina

Email: pnikel@unsam.edu.ar, pablo@qb.fcen.uba.ar

Qualifications

2009  Ph.D., University of San Martin, Molecular Biology & Biotechnology
2004  B.Sc., University of San Martin, Biotechnology

Publications (Selected)

1. Cabrera-Gomez JG, da Silva LF, Méndez BS, Nikel PI, Pettinari MJ, Prieto MA (2011) Making green polymers even greener: Towards sustainable production of poly(hydroxyalkanoates) from agroindustrial by-products. In: Biotechnology, M. Petre (Ed.). InTech-Open Access Publisher, Rijeka, Croatia. ISBN 978-953-307-635-5.
2. Nikel PI, Giordano AM, de Almeida A, Godoy MS, Pettinari MJ (2010) Elimination of D-lactate synthesis increases poly(3-hydroxybutyrate) and ethanol synthesis from glycerol and affects cofactor distribution in recombinant Escherichia coli. Applied & Environmental Microbiology, 76: 7400-6.
3. Nikel PI, Pettinari MJ, Galvagno MA, Méndez BS (2010) Metabolic selective pressure stabilizes plasmids carrying biosynthetic genes for reduced biochemicals in Escherichia coli redox mutants. Applied Microbiology & Biotechnology, 88: 563-73.
4. Nikel PI, Ramírez MC, Pettinari MJ, Méndez BS, Galvagno MA (2010) Ethanol synthesis from glycerol by Escherichia coli redox mutants expressing adhE from Leuconostoc mesenteroides. Journal of Applied Microbiology, 109: 492-504.
5. Nikel PI, de Almeida A, Giordano AM, Pettinari MJ (2010) Redox driven metabolic tuning: carbon source and aeration affect synthesis of poly(3-hydroxybutyrate) in Escherichia coli. Bioengineered Bugs, 1: 1-4.
6. de Almeida A, Giordano AM, Nikel PI, Pettinari MJ (2010) Effects of aeration on the synthesis of poly(3-hydroxybutyrate) from glycerol and glucose in recombinant Escherichia coli. Applied & Environmental Microbiology, 76: 2036-40.
7. Nikel PI, Zhu J, San KY, Méndez BS, Bennett GN (2009) Metabolic flux analysis of Escherichia coli creB and arcA mutants reveals shared control of carbon catabolism under microaerobic growth conditions. Journal of Bacteriology, 191: 5538-48.
8. Nikel PI (2009) Metabolites of biotechnological interest à la carte: Metabolic flux analysis as a relevant tool for industrial phenotypes evaluation. Live Chemistry, 8: 125-44.
9. Nikel PI, de Almeida A, Pettinari MJ, Méndez BS (2008) The legacy of HfrH: Mutations in the two-component system CreBC are responsible for the unusual phenotype of an Escherichia coli arcA mutant. Journal of Bacteriology, 190: 3404-7.
10. Kronberg MF, Nikel PI, Cerrutti P, Galvagno MA (2008) Modeling the freezing response of baker’s yeast pre-stressed cells: A statistical approach. Journal of Applied Microbiology, 104:716-27.
11. Nikel PI, Pettinari MJ, Ramírez MC, Galvagno MA, Méndez BS (2008) Escherichia coli arcA mutants: Metabolic profile characterization of microaerobic cultures using glycerol as a carbon source. Journal of Molecular Microbiology & Biotechnology, 15: 48-54.
12. Pettinari MJ, Nikel PI, Ruiz JA, Méndez BS (2008) ArcA redox mutants as a source of reduced bioproducts. Journal of Molecular Microbiology & Biotechnology, 15: 41-7.
13. Nikel PI, Pettinari MJ, Galvagno MA, Méndez BS (2008) Poly(3-hydroxybutyrate) synthesis from glycerol by a recombinant Escherichia coli arcA mutant in fed-batch microaerobic cultures. Applied Microbiology & Biotechnology, 77: 1337-43.
14. de Almeida A, Nikel PI, Giordano AM, Pettinari MJ (2007) Effects of granule-associated protein PhaP on glycerol-dependent growth and polymer production in poly(3-hydroxybutyrate)-producing Escherichia coli. Applied & Environmental Microbiology, 73: 7912-6.
15. Nikel PI, Pettinari MJ, Galvagno MA, Méndez BS (2006) Poly(3-hydroxybutyrate) synthesis by recombinant Escherichia coli arcA mutants in microaerobiosis. Applied & Environmental Microbiology, 72: 2614-20.
16. Nikel PI, de Almeida A, Melillo EC, Galvagno MA, Pettinari MJ (2006) New recombinant Escherichia coli strain tailored for the production of poly(3-hydroxybutyrate) from agroindustrial by-products. Applied & Environmental Microbiology, 72: 3949-54.
17. Ruiz JA, Fernández RO, Nikel PI, Méndez BS, Pettinari MJ (2006) dye (arc) mutants: Insights into an unexplained phenotype and its suppression by the synthesis of poly(3-hydroxybutyrate) in Escherichia coli recombinants. FEMS Microbiology Letters, 258: 55-60.
18. Nikel PI, Pettinari MJ, Méndez BS, Galvagno MA (2005) Statistical optimization of a culture medium for biomass and poly(3-hydroxybutyrate) production by a recombinant Escherichia coli strain using agroindustrial by-products. International Microbiology, 8: 243-50.