Prof. Hung-Jen Liu

Institute of Molecular Biology
National Chung Hsing University, Chinese Taipei

Professor

Email: hjliu5257@nchu.edu.tw

Qualifications

1993 M.Sc., Auburn University, USA

1984 DVM, National Pingtung University of Science and Technology, Chinese Taipei

Publications (Selected)

1. Wu YY, Sun TK, Chen MS, Munir M, Liu HJ*. Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response. Frontiers in Cellular and Infection Microbiology13:1142172, 2023.
2. Huang WR, Wu YY, Liao TL, Nielsen BL, Liu HJ*. Cell entry of avian reovirus modulated by cell-surface annexin A2 and adhesion G protein-coupled receptor latrophilin-2 triggers Src and p38 MAPK signaling enhancing caveolin-1- and dynamin 2-dependent endocytosis. Microbiology Spectrum 11: 3, 2023.
3. Hsu CY, Yang CH, Tung MC, Liu HJ*, Ou YC*. Robot-assisted urologic cancer surgery: current standards and future trends. Cancers , 15, 4288, 2023.
4. Sitinjak MC, Chen JK, Lee MY, Liu HJ, Wang CY. Characterization of a novel reporter system for beak and feather disease virus. Gene 867: 147371, 2023.
5. Hsu CY, Huang JW, Huang WR, Chen IC, Chen MS, Liao TL, Chang YK, Munir M, Liu HJ*. Oncolytic avian reovirus σA-modulated upregulation of the HIF-1α/C-myc/glut1 pathway to produce more energy in different cancer cell lines benefiting virus replication. Viruses 15:523, 2023.
6. Hsu CY, Hsieh CY, Yang CY, Chang YK, Shih WL, Yeh CM, Hu NJ, Chen MS, Nielsen BL, Liu HJ*. Sortase A fusion expression and mIFc2 co-expression of bovine lactoferricin and analysis of its antibacterial activity. Processes 10: 2470, 2022
7. Chen TM, Liu PY, Tang KT, Liu HJ, Liao TL. TWEAK-Fn14 axis induces calcium-associated autophagy and cell death to control Mycobacterial survival in macrophages. Microbiology Spectrum 10(6):e0317222, 2022.
8. Li JY, Huang WR, Liao TL, Nielsen BL, Liu HJ*. Oncolytic avian reovirus p17-modulated inhibition of mTORC1 by enhancement of the endogenous mTORC1 inhibitors binding to mTORC1 to disrupt its assembly and accumulation on lysosomes. Journal of Virology 96 (17), e0083622, 2022.
9. Huang WR, Li JY, Wu YY, Liao TL, Nielsen BL, Liu HJ*. p17-modulated Hsp90/Cdc37 complex governs avian reovirus replication by chaperoning p17 that promotes viral protein synthesis and accumulation of proteins σA and σC in viral factories. Journal of Virology 96(6): e0007422, 2022.
10. Hsu CY, Chen YH, Huang WR, Huang JW, Chen IC, Chang YK, Wang CY, Chang CD, Liao TL, Nielsen BL, Liu HJ*. Avian reovirus σA‐modulated fatty acid synthesis and oxidation through the PSMB6/Akt/REBP1/acetyl-CoA arboxylase pathway to increase energy production for virus replication. Veterinary Microbiology 273: 109541, 2022.
11. Wei‐Ru Huang, Jyun-Yi Li, Tsai-Ling Liao, Chuan-Ming Yeh, Chao-Yu Hsu, Yu-Kang Chang, Ching-Dong Chang, Brent L. Nielsen, Hung-Jen Liu*. Molecular chaperone TRiC governs avian reovirus replication by preventing outer-capsid protein σC and core protein σA and non-structural protein σNS from ubiquitin-proteasome degradation. Veterinary Microbiology 264: 109277, 2022.
12. Liu FL, Chang SP, Liu HJ, Liu PC, Wang CY. Genomic and phylogenetic analysis of avian polyomavirus Taiwan isolates. Virus Research 08: 196834, 2022.
13. Liao TL, Chen YM, Hsieh SL, Tang KT, Chen DY, Yang YY, Liu HJ, Yang SS. Hepatitis C virus-induced exosomal microRNAs and TLR7 polymorphism regulate B-cell activating factor. mBio12(6): e02764-21, 2021.
14. Liao TL, Chen YM, Tang KT, Chen PK, Liu HJ, Chen DY. MicroRNA 223 inhibits neutrophil extracellular traps formation through regulating calcium infux and Small extracellular vesicles transmission. Scientific Report 11:15676, 2021.
15. Wen HW, Liu HJ. A rapid lateral flow assay using immunomagnetic nanoparticles for detecting mango allergen residues in processed foods. Journal of Food Safety e:12929, 2021.
16. Chen IC, Kuo PH, Yang AC, Tsai SJ, Liu TH, Liu HJ*, Lan TH, Chen HM, Huang HN, Chung RH, Liu YL*. CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific Report 10: 18118, 2020.
17. Tseng HH, Huang WR, Cheng CY, Chiu HC, Liao TL, Nielsen BL, Liu HJ*. Aspirin and 5-aminoimidazole-4- carboxamide riboside attenuate bovine ephemeral fever virus replication by inhibiting BEFV-induced autophagy. Frontier in Immunology 11: 556838, 2020.
18. Chen YY, Yang WC, Chang YK, Wang CY, Huang WR, Li JY, Wu HY, Chang CD, Nielsen BL, Liu HJ*. Construction of polycistronic baculovirus surface display vectors to express the PCV2 Cap(d41) protein and its immunogenicity of the expressed proteins in mice and swine. Veterinary Research 51:112, 2020.
19. Santos HＭ, Tsai CY, Catulin GEM, Trangia KCG, Tayo LL, Liu HJ, Chuang KP. Common bacterial, viral and parasitic diseases in pigeons (Columba livia): A review of diagnostic and treatment strategies. Veterinary Microbiol. 247:108779, 2020.
20. Tung MC, Lu HY, Chang YK, Huang WR, Liao TL, Wu HY, Chang CD, Nielsen BL, Liu HJ*. Baculovirus surface display of the HA protein of H5N2 avian influenza virus and its immunogenicity against a lethal challenge with H5N1 virus in chickens. Veterinary Microbiology 243, 108640, 2020.
21. Chen DY, Chen YM, Lin CF, Lo CM, Liu HJ, Liao TL. MicroRNA-889 inhibits autophagy to maintain mycobacterial survival in patients with latent tuberculosis infection by targeting TWEAK. mBio 11(1), e03045-19, 2020.
22. Chen IC, Teng G, Chen CJ, Lan TH, Liu HJ*. The autonomic progress bar motivates treatment completion for patients of stimulant use disorder and cannabis use disorder. Frontiers in Psychiatry 10, 944, 2020.
23. Chiu HC, Huang WR, Wang YY, Li JY, Liao TL, Nielsen B, Liu HJ*. Heterogeneous nuclear ribonucleoprotein A1 and lamin A/C modulate nucleocytoplasmic shuttling of avian reovirus p17. Journal of Virology 93(20): 00851-19, 2019.
24. Cheng CY, Tseng HH, Chiu HC, Chang CD, Nielsen BL, Liu HJ*. Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway. Veterinary Research 50: 79, 2019.
25. Wang Q, Huang WR, Chih WY, Chuang KP, Chang CD, Wu Y, Huang Y, Liu HJ*. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis. Veterinary Microbiology 235:151-163, 2019.
26. Wang Q, Liu M, Chen Y, Xu L, Wu B, Wu Y, Huang Y, Huang WR, Liu HJ*. Muscovy duck reovirus p10.8 protein induces ER stress and apoptosis through the Bip/IRE1/XBP1 pathway. Vet. Microbiol. 228: 234-245, 2019.