Dr. Wange Lu

Department of Biochemistry and Molecular Biology

University of Southern California, USA
Assistant Professor




1990   B.S., Nankai University, China
1993   M.S., Beijing University, China
1998   Ph.D., Harvard University, UK 


  1. Lu, W., Dang, W., Zhang, G., Zhu, Y and Chen, Z. (1994). Expression of Trichosanthin in Saccharomyces cerevisiae.   J Biotechnol  10(2), 173-177.
  2. Dang, W., Lu, W., Cao, X., Pan N. and Chen, Z. (1994). Cloning of tomato polygalacturonase cDNA and transforming plants with antisense RNA.  Acta Botanica Sinica 36, 171-177.  
  3. Lu, W., Katz, S., Gupta, R., and Mayer, B. J. (1997). Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol 7, 85-94.  
  4. Tanaka, M., Lu, W., Gupta, R., and Mayer, B. J. (1997). Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development. Proc Natl Acad Sci U S A 94, 4493-4498.  
  5. Evans, E. K., Lu, W., Strum, S. L., Mayer, B. J., and Kornbluth, S. (1997). Crk is required for apoptosis in Xenopus egg extracts. EMBO J 16, 230-241.  
  6. Nikolic, M., Chou, M. M., Lu, W., Mayer, B. J., and Tsai, L. H. (1998). The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 395, 194-198.  
  7. Anton, I. M., Lu, W., Mayer, B. J., Ramesh, N., and Geha, R. S. (1998). The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J Biol Chem 273, 20992-20995. 
  8. Manninen, A., Hiipakka, M., Vihinen, M., Lu, W., Mayer, B. J., and Saksela, K. (1998). SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 250, 273-282. 
  9. Lu, W., and Mayer, B. J. (1999). Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 18, 797-806.  
  10. Lei, M., Lu, W., Meng, W., Parrini, M. C., Eck, M. J., Mayer, B. J., and Harrison, S. C. (2000). Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102, 387-397.  
  11. Lu, W., Yamamoto, V., Ortega, B. and Baltimore, D. (2004). Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 119, 97-108.  
  12. Lyu, J, Yamamoto, V, and Lu. W. (2008) Cleavage of Wnt Receptor Ryk Regulates Neuronal Differentiation During Cortical Neurogenesis. Developmental Cell. 5(5):773-80.  
  13. Lyu, J., Wesselschmidt, RL and Lu, W (2009). Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain, Journal of Biological Chemistry, 284(19):12940-8 
  14. Wei, Z., Yang, Y., Zhang, P., Andrianakos, R., Hasigawa, K., Lyu, J., Chen, X., Bai, G., Liu, C., Pera, M. and Lu. W (2009). Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells, 27(12):2969-78.  
  15. Zhong, J.F., Weiner, L.P., Jin, Y, Lu W, Taylor, C.R. (2010): A real-time pluripotency reporter for human stem cell.  Stem Cells Dev., 19(1):47-52 
  16. Zhang, P., Adrianakos, R., Yang, Y. and Lu, W (2010), Kruppel-like factor 4 (KLF4) prevents embryonic stem (ES) cell differentiation by regulating nanog gene expression., Journal of Biological Chemistry, 285(12): 9180-9. 
  17. Hasegawa K, Zhang P, Wei Z, Pomeroy JE, Lu W, Pera MF (2010), Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. Stem Cells, 28(8):1338-48.
  18. Choi SH, Heo K, Byun HM, An W, Lu W, Yang AS (2011), Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Research. 39(1):104-18. 
  19. Zhong, J., Kim, H., Lyu, J., Yoshikawa, K Nakafuku, M. and Lu, W (2011), Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development. Development, 138(3):409-19. 
  20. Lyu, J., Jho, E. and Lu, W (2011), Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells, Cell Research, 21(6):911-21. 
  21. Choi J, Kim H, Kim K, Lee B, Lu W, An W. (2011), Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing, Nucleic Acids Res. epub Aug 16, 2011. 

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Last Updated: December 12, 2011.

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