Dr. Shile Huang

Department of Biochemistry and Molecular Biology
Louisiana State University Health Sciences Center, USA
Associate Professor





1994- 1997   Ph.D., Institute of Zoology, University of Salzburg, Austria

1984- 1987   M.S., Nanjing Agricultural, University, Nanjing, China

1980- 1984   B.S., Anhui Agricultural University, China



  1. Luo Y, Liu L, Rogers D, Su W, Zhou H, Chen W, Shen T, Alexander JS, Huang S* (2011) Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating VEGFR-3 protein expression. Cell Mol Life Sci. (submitted) 
  2. Lee YJ, Burlet E, Wang S, Xu B, Huang S, Galiano FJ, Witt SN. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem Biophys Res Commun. 2011 Sep 16. [Epub ahead of print] 
  3. Chen S, Xu Y, Xu B, Guo M, Zhang Z, Liu L, Ma H, Chen Z, Luo Y, Huang S*, Chen L*. CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal apoptosis. J Neurochem. 2011 Sep 20. [Epub ahead of print]. PMID: 21933187 
  4. Luo Y, Chen W, Zhou H, Liu L, Shen T, Alexander JS, Zheng S, Lu Y, Huang S* (2011) Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways. Cancer Prev Res. 2011 Aug 31. [Epub ahead of print]. PMID: 21881029 
  5. Chen L, Zheng SZ, Sun ZG, Wang AY, Huang CH, Punchard NA, Huang SL, Gao X, Lu Y (2011). Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother Pharmacol. 68:17-27. PMID: 20820782; PMCID: PMC3032829 
  6. Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L*, Huang S* (2011) Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS One 6: e19052. PMID:21544200 
  7. Luo Y, Zhou H, Liu L, Shen T, Chen W, Xu B, Han X, Alexander JS, Alam A, Huang S* (2011) The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene. 30:2098-2107. PMID: 21217783; PMCID: PMC3088775 
  8. Chen L, Xu B, Liu L, Luo Y, Zhou H, Chen W, Shen T, Han X, Kontos CD, Huang S* (2011) Cadmium induction of reactive oxygen species activates mTOR pathway, leading to neuronal cell death. Free Radic Biol Med. 50:624-632. PMID: 21195169; PMCID: PMC3032035 
  9. Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X, Huang S* (2010) Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem. 285:38362-38373. PMID: 20937815; PMCID: PMC2992269 
  10. 10. Zhou H, Shen T, Luo Y, Liu L, Chen W, Xu B, Han X, Rivera CA, Huang S* (2010) The antitumor activity of the fungicide ciclopirox. Int J Cancer 127:2467-2477. PMID: 20225320; PMCID: PMC2888914 
  11. Chen W, Luo Y, Liu L, Zhou H, Xu B, Han X, Shen T, Liu Z, Lu Y, Huang S* (2010) Cryptotanshinone inhibits cancer cell proliferation by suppressing mTOR-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res. 3:1015-1025. PMID: 20628002; PMCID: PMC2917475 
  12. Liu L, Chen L, Luo Y, Chen W, Zhou H, Xu B, Han X, Shen T, Huang S* (2010) Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. PLoS One 5:e10578. PMID: 20485667; PMCID: PMC2868031 
  13. Chen L, Xu B, Liu L, Luo Y, Yin J, Zhou H, Chen W, Shen T, Han X, Huang S* (2010) Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells. Lab Invest. 90:762-773. PMID: 20142804; PMCID: PMC2861733 
  14. Chen L, Liu L, Yin J, Luo Y, Huang S* (2009) Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol. 41:1284-1295. PMID: 19038359 
  15. Beevers CS, Chen L, Liu L, Luo Y, Webster NJG, Huang S* (2009) Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res. 69:1000-1008. PMID: 19176385 
  16. Kim HI, Huang H, Cheepala S, Huang S, Chung J (2008) Curcumin inhibition of integrin (α6β4) dependent cancer cell motility. Cancer Prev Res. 1:385-391. PMID: 19138983 
  17. Chen L, Liu L, Huang S* (2008) Cadmium activates MAPK pathway via induction of reactive oxygen species and inhibition of protein phosphatase 2A and 5. Free Radic Biol Med. 45:1035-1044. PMID: 18703135 
  18. Liu L, Chen L, Chung J, Huang S* (2008) Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene 27:4998-5010. PMID: 18504440; PMCID: PMC2562907 
  19. Chen L, Liu L, Luo Y, Huang S* (2008) MAPK and mTOR pathways are involved in cadmium- induced neuronal apoptosis. J Neurochem. 105:251-261. PMID: 18021293 
  20. Zhan J, Easton JB, Huang S, Mishra A, Xiao L, Lacy ER, Kriwacki R, and Houghton PJ (2007) Negative regulation of ASK1 by p21Cip1 involves a small domain that includes serine 98 that is phosphorylated by ASK1 in vivo. Mol Cell Biol. 27:3530-3541. PMID: 17325029; PMCID: PMC1899956 
  21. Liu L, Li F, Cardelli, JA, Martin KA, Blenis J, Huang S* (2006) Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 25:7029-7040. PMID: 16715128 
  22. Beevers CS, Li F, Liu L, Huang S* (2006) Curcumin inhibits the mammalian target of rapamycin- mediated signaling pathways in cancer cells. Int J Cancer 119:757-764. PMID: 16550606 
  23. Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ (2004) Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem. 279:36490-36496. PMID: 15218033 
  24. Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ (2003) Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1. Mol Cell. 11:1491-1501. PMID: 12820963 
  25. Thimmaiah KN, Easton J, Huang S, Veverka KV, Germain GS, Harwood FC, Houghton PJ (2003) Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling pathways. Cancer Res. 63: 364-374. PMID: 12543789 
  26. Huang S, Liu L, Hosoi H, Dilling MB, Shikata T, Houghton PJ (2001) p53/p21CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin. Cancer Res. 61:3373-3381. PMID: 11309295 
  27. Kerschbaum HH, Huang S, Xie M, Hermann A (2000) NADPH-diaphorase activity and nitric oxide synthase activity in the kidney of the clawed frog, Xenopus laevis. Cell Tissue Res. 301:405-411. PMID: 10994786

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Last Updated: December 9, 2011.

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