Dr. Andrew Craig

Department of Biomedical & Molecular Sciences

Queen’s University, Jamaica
Associate Professor 

Email: andrew.craig@queensu.ca

Qualifications

1998   Ph.D., Department of Biochemistry, McGill University, Canada
1993   B.Sc., Honours, Queen’s University, Jamaica 

Publications

1. Andrew W.B. Craig (2012) FES/FER kinase signaling in hematopoetic cells and leukemias. Frontiers in Bioscience, 17:861-875. 
2. Peilin Ma, Raghuveer Singh Mali, Veerendra Munugalavadla, Subha Krishnan, Baskar Ramdas, Emily Sims , Holly Martin, Joydeep Ghosh, Shou Li, Rebecca Chan, Gerald Krystal, Andrew W. Craig, Clifford Takemoto and Reuben Kapur (2011) The PI3K drives the maturation of mast cells via microphthalmia transcription factor, Blood, 118:3459-69. 
3. Jinghui Hu, Alka Mukhopadhyay, Peter Truesdell, UK Mukhopahyay, Alan Mak and Andrew WB Craig (2011) Cdc42-Interacting Protein 4 is a Src substrate that regulates invadopodia and breast tumor invasiveness via promoting MT1-MMP endocytosis, J. Cell Sci., 124: 1739-1751. 
4. Jinghui Hu, Alka Mukhopadhyay and Andrew WB Craig (2011) Transducer Of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness, J. Biol. Chem., 286:2261-72. 
5. Julie Smith, Lionel Samayawardhena and Andrew Craig (2010) Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and 1 integrin receptors, Cell. Signal, 22:427-436. 
6. Victor A. McPherson, Namit Sharma, Stephanie Everingham, Julie Smith,  Helen H. Zhu, Gen-Sheng Feng and Andrew W.B. Craig (2009) SHP2 Protein-Tyrosine Phosphatase Promotes FcεRI-induced Activation of Fyn and Erk Pathways Leading to TNFα Release from Bone Marrow-derived Mast Cells, J. Immunol., 183:4940-4947. 
7. Jinghui Hu, Flavia Troglio , Alka Mukhopadhyay, Stephanie Everingham, Ester Kwok, Giorgio Scita, and Andrew W.B. Craig (2009) F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation, Cell. Signal, 21, 1686-1697. 
8. Victor McPherson, Stephanie Everingham, Robert Karisch, Julie Smith, Chris Udell, Jimin Zheng, Zongchao Jia, and Andrew W.B. Craig (2009) Contributions of F-BAR and SH2 Domains of FES Protein-Tyrosine Kinase For Coupling to the FcRI Pathway in Mast Cells, Mol. Cell. Biol. 29:389-401. 
9. Lei Liu, Andrew W. Craig, Heather D. Meldrum, Bruce E. Elliott, and Marlys L. Koschinsky (2008) Integrin V 3 is Required for Apolipoprotein(a) Stimulation of Vascular Endothelial Cell Growth and Migration, Biochem. J., 418:325-36. 
10. Lionel A. Samayawardhena, Reuben Kapur and Andrew W.B. Craig (2007) Involvement of Fyn kinase in c-Kit and integrin-mediated Rac activation, cytoskeletal reorganization and chemotaxis of mast cells, Blood, 109:3679-3686. 
11. C.M. Udell, L.A. Samayawardhena, Y. Kawakami, T. Kawakami, and A.W.B. Craig (2006) Fer and Fps/Fes participate in a Lyn-dependent pathway from FcεRI to Platelet-Endothelial Cell Adhesion Molecule-1 to limit mast cell activation, J. Biol. Chem., 281:20949-20957. 
12. L. Samayawardhena, J. Hu, P. Stein, and A.W.B. Craig (2006) Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor, Cell. Signal, 18: 1447-54. 
13. W. Qi, K.V.J. Ebbert, A.W.B. Craig, P.A. Greer and D.M. McCafferty (2005) Absence of Fer protein-tyrosine kinase exacerbates endotoxin-induced intestinal epithelial barrier dysfunction in vivo, Gut, 54:1091-97. 
14. G. Xu, A.W.B. Craig, P. Greer, M. Miller, P.Z. Anastasiadis, J. Lilien and J. Balsamo (2004). Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine kinase Fer. J. Cell Sci,117:3207-3219. 
15. L. Fan, C. Di Ciano-Oliviera, S.A. Weed, A.W.B. Craig, P.A. Greer, O.D. Rotstein and A. Kapus (2004). Actin Depolymerization-Induced Tyrosine Phosphorylation of Cortactin: The Role of Fer Kinase. Biochem. J.,380:581-591. 
16. A. Vultur, J. Cao, R. Arulanandam, J. Turkson, R. Jove, P. Greer, A. Craig, B. Elliot and L. Raptis (2004) Cell to cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene, 23:2600-2616. 
17. Y.A. Senis*, A.W.B. Craig* and P.A. Greer (2003). Fps/Fes and Fer Protein-Tyrosine Kinases Play Redundant Roles in Regulating Hematopoiesis. Exp. Hematol., 31:673-81. *co-first authors
18. Y.A. Senis, W. Sangrar, R. Zirngibl, A.W.B. Craig, D.H. Lee and P.A. Greer (2003). Fps/Fes and Fer non- receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation. J. Thrombosis and Haemostasis, 1:1062-70. 
19. A.W.B. Craig and P.A. Greer (2002). Fer Kinase Is Required For Sustained p38 Kinase Activation and Maximal Chemotaxis of Activated Mast Cells. Mol. Cell. Biol., 22: 6363-6374. 
20. D-M. McCafferty, A.W.B. Craig, Y.A. Senis and P.A. Greer (2002).  Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J. Immunol., 168: 4930-4935. 
21. A.W.B. Craig, R. Zirngibl, K. Williams, L.A. Cole and P. Greer (2001).  Mice Devoid of Fer Protein-Tyrosine Kinase Activity are Viable and Fertile, But Display Reduced Cortactin Phosphorylation. Mol. Cell. Biol. 21: 603-613. 
22. Khaleghpour, Y.V. Svitkin, A.W. Craig, C.T. DeMaria, R.C. Deo, S.K. Burley and N. Sonenberg (2001)
23. Translational Repression by a Novel Partner of Human Polyadenylate Binding Protein. Mol. Cell 7: 9-20. 
24. A.W.B. Craig, R. Zirngibl and P. Greer (1999) Disruption of Coiled-Coil Domains in Fer Protein Tyrosine
25. Kinase Abolishes Trimerization But Not Kinase Activation. J. Biol. Chem. 274: 19934-4 
26. L.A. Cole, R. Zirngibl, A.W.B. Craig, Z. Jia and P. Greer (1999) Mutation of a highly conserved aspartate residue in subdomain IX abolishes FER protein-tyrosine kinase activity. Prot. Eng. 12:155-162. 
27. A.W.B. Craig, A. Haghighat, A.T.K. Yu and N. Sonenberg (1998) Enhanced translation via interaction of polyadenylate binding protein with the eIF4G homologue PAIP. Nature 392: 520-523. 
28. A.W.B. Craig, Y.V. Svitkin, H.S. Lee, G.J. Belsham and N. Sonenberg (1997) The La autoantigen contains a dimerization domain that is essential for enhancing translation. Mol. Cell. Biol . 17: 163-9.
29. A.W.B. Craig, G.P. Cosentino, O. Donze and N. Sonenberg (1996) The kinase insert domain of the interferon- induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L. J. Biol. Chem. 271: 24526-33. 
30. A. Lu, A. Craig, R. Casselman and E.B. Carstens (1996) Nucleotide sequence, insertional mutagenesis, and transcriptional mapping of a conserved region of the baculovirus Autographa californica nuclear polyhedrosis virus (map unit 64.8-64.9). Can. J. Microbiol. 42: 1267-73. 
31. A.E. Koromilas, C. Cantin, A.W.B. Craig, R. Jagus, J. Hiscott and N. Sonenberg (1995) The interferon- inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. J. Biol. Chem. 270: 25426-34.
32. T.R. Narasimhan, A. Craig, L. Arellano, N. Harper, L. Howie, M. Menache, L. Birnbaum and S. Safe (1994) Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fund. Appl. Toxicol. 23: 598-607. 
33. M. Moore, X. Wang, Y.F. Lu, M. Wormke, A. Craig, J.H. Gerlach, R. Burghardt, R. Barhoumi and S. Safe (1994) Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone. J. Biol. Chem. 269: 11751-9. 
34. N. Harper, L. Howie, K. Connor, L. Arellano, A. Craig, R. Dickerson and S. Safe (1993) Immuno-suppressive and monooxygenase activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice. Fund. Appl. Toxicol. 20: 496-502. 

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Last Updated: December 9, 2011.

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