Dr.
Kailash C. Chadha
Roswell
Park Cancer Institute, USA
Email:
kailash.Chadha@roswellpark.org
Qualifications
1968 Ph.D., University of Guelph, Canada
1965 M.Sc., I.A.R.I., India
1962 B.Sc., University of Rajasthan, India
Publications
(Selected)
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Chadha
KC, Sykes DE, Dembinski WE, Ambrus JL, Sr. Why do most cancer patients respond
poorly to interferon therapy? Proceedings Intl. Symposium on Recent aAdvances
in Molecular Biology, Allergy & Immunology, 3-5th Sept 2000 Baroda India,
pg. 179-185.
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Nair
MPN, Mahajan S, Chadha K, Nair N, Hewitt R, Pillai SK, Chadha P, Sukumaran PC,
Schwartz SA. Effect of cocaine on chemokine and CCR-5 gene expression by
mononuclear cells from normal donors and HIV-1 infected patients. In
“Neuroimmune Circuits, Drugs of Abuse and Infectious Diseases.” Adv Exp Med
Biol. 493:235-40, 2001.
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Chadha
KC, Kawinski E, Sulkowski E. Thiophilic interaction chromatography of
prostate-specific antigen. J Chromatog. B. 754(2): 521-525, 2001.
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Kawinski
E, Levine E, Chadha K. Thiophilic interaction chromatography facilities
detection of various molecular complexes of prostate-specific antigen in
biological fluids. Prostate 50(3): 145-153, 2002.
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Nair
MPN, Kaudaswami C, Mahajan S, Chadha KC, Chawda R, Nair N, Kumar N, Schwartz
SA. The flavonoid, Quecertin, differentially regulates Th-1 (IFN-y) and Th-2
(IL4) cytokine gene expression by normal peripheral blood mononuclear cells.
Biochem Biophys Acta 1593(1): 29-36, 2002.
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Aalinkeel
RK, Nair MPN, Sufrin G, Mahajan SD, Chadha KC, Schwartz, SA. Antisense
inhibition of the cyclo-oxygenase-2 gene modulates the expression of
pro-angiogenic molecules in prostate cancer cell lines. J Urol 169:220, 2003.
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Ambrus
JL Sr, Dembinski W, Ambrus JL Jr, Sykes DE, Akhter S, Kulaylat MN, Islam A,
Chadha KC. Free interferon -alpha/beta receptors in the circulation of patients
with adenocarcinomas. Cancer 98:2730-2733, 2003.
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Chadha
KC, Schwartz SA, Nair MPN, Demeter LR, Hewitt RG. Serum interferon inhibitor
declines in patients with HIV-1 infection after a change in antiretroviral
therapy. Immunol Invest 32:299-312, 2003.
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Ambrus
JL Sr, Dembinski W, Ambrus JL Jr, Sykes DE, Akhter S, Kulaylat MN, Islam A,
Chadha KC. Free interferon -alpha/beta receptors in the circulation of patients
with adenocarcinomas. Cancer 98:2730-2733, 2003.
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Chadha
KC, Ambrus JL Jr, Dembinski W, Ambrus JL Sr. Interferon and interferon
inhibitory activity in disease and therapy. Mini Review. Exp Biol Med 229(4):285-290,
2004.
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Sulkowski
E, Chadha K, Kawinski E. A method for detecting PSA and its
molecular forms using thiophilic gel on magnetic beads. U.S. Patent No.
6,692,643, issued February 17, 2004.
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Aalinkeel
R, Nair MPN, Sufrin G, Mahajan SD, Chadha KC, Chawda RP, Schwartz SA. Gene
expression of angiogenic factors correlates with metastatic potential of
prostate cancer cells. Cancer Res 64:5311-5321, 2004.
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Chadha
KC, Dembinski WE, Dunn CB, Ardi J, Bardos TJ, Dunn JA, Ambrus Sr JL. Effect of
increasing thiolation of the polycytidylic acid strand of poly I:poly C on the
alpha, beta and gamma interferon inducing properties, antiviral and
antiproliferative activities. Antiviral Res. 64: 171-177, 2004.
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Bindukumar
B, Kawinski E, Cherrin C, Gambino LM, Nair MPN, Schwartz SA, Chadha KC.
Two-step procedure for purification and characterization of enzymatically
active prostate-specific antigen from seminal plasma. J Chromatogr B. 813:
113-120, 2004.
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Ambrus
JL Sr, Dembinski WD, Chadha Kunal, Ambrus JL Jr, Chadha KC. Resistance to
interferons, Discovery Medicine, 4: 310-314, 2004.