Prof. Ildikó Rácz

Institute of Molecular psychiatry

University of Bonn, Germany

Email: iracz@uni-bonn.de

Qualifications

1996 Ph.D., Eötvös Lóránd University, Budapest, Hungary

1986 M.Sc., Eötvös Lóránd University of Sciences, Budapest, Hungary

Publications (Selected)

1. Pradier B, Erxlebe E, Markert A, Rácz I. Interaction of cannabinoid receptor 2 and social environment modulates chronic alcohol consumption Behav Brain Res. 2015 Mar 28;287:163-171. doi: 10.1016/j.bbr.2015.03.051.

2. Klauke A-L*, Racz I. * Pradier B, Markert A, Zimmer A, Gertsch J. Zimmer A. The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol. 2014 Apr; 24(4):608-20.

3. Pradier B, Jeub M, Markert A, Mauer D, Tolksdorf K, Van de Putte T, Seuntjens E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Huylebroeck D, Beck H, Zimmer A, Rácz I. Smad-interacting protein 1 affects acute and tonic, but not chronic pain. Eur J Pain. 2013.

4. Racz I, Markert A, Mauer D, Stoffel-Wagner B, Zimmer A. Long-term ethanol effects on acute stress responses: Modulation by dynorphin. Addict Biol. 2013 Jul;18(4):678-88.

5. Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013 Aug 1;123(8):3272-91.

6. Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int. (2011) Jul;31(6):862-72.

7. Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J. Requirement of the RNA editing enzyme ADAR2 for normal physiology in mice. J Biol Chem. 2011 Apr 5.

8. Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempel M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, Hrabě de Angelis M. Mouse phenotyping. Methods. 2010 Aug 12. (3,763)

9. Bilkei-Gorzo A, Berner J, Zimmermann J, Wickström R, Racz I, Zimmer A. Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene. Br J Pharmacol. 2010 Jul;160(6):1443-52.

10. Frisch P, Bilkei-Gorzó A, Rácz I, Zimmer A. Modulation of the CRH system by substance P/NKA in an animal model of depression. Behav Brain Res. 2010 Nov 12;213(1):103-8.

11. Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, de Angelis MH, Atkinson M, Heinzmann U, Graw J. Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome. 2010 Feb;21(1-2):13-27.

12. Drews E, Rácz I, Lacava AD, Barth A, Bilkei-Gorzó A, Wienker TF, Zimmer A Quantitative trait loci contributing to physiological and behavioural ethanol responses after acute and chronic treatment. Int J Neuropsychopharmacol. 2010 Mar;13(2):155-69.

13. Wirth EK, Roth S, Blechschmidt C, Hölter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Bräuer A, de Angelis MH, Köhrle J, Grüters A, Schweizer U. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci. 2009 Jul 29;29(30):9439-49.

14. Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71.

15. Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D, Zimmer A. Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6. Eur Neuropsychopharmacol. 2009 Sep;19(9):670-81.

16. Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 2009 Feb;10(2):236-43.

17. Racz I., X. Nadal, J. Alferink, J. E. Baños, J. Rehnelt, M. Martín, B. Pintado, A. Gutierrez-Adan, E. Sanguino, J. Manzanares, A. Zimmer, R. Maldonado, Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain J of Neuroscience (2008) 28(46):12125-35.

18. Racz I., X. Nadal, J. Alferink, J. E. Baños, J. Rehnelt, M. Martín, B. Pintado, A. Gutierrez-Adan, E. Sanguino, N. Bellora, J. Manzanares, A. Zimmer, R. Maldonado, Interferon-γ is a critical modulator of CB2 cannabinoid receptor signaling during neuropathic pain J of Neuroscience (2008) 28(46): 12136-45.

19. Rácz I., A. Bilkei-Gorzo, A. Markert, F. Stamer, M. Göthert and A. Zimmer, Anandamide effects on 5-HT3 receptors in vivo Eur J Pharmacol, (2008) 31;596(1-3):98-101.

20. Racz, I. B. Schürmann, A. Karpushova, M. Reuter, S. Cichon, C. Montag, R. Fürst, C. Schütz, P. E. Franke, J. Strohmaier, T. F. Wienker, L. Terenius, U. Ösby, A. Gunnar, W. Maier, A. Bilkei-Gorzó, M. Nöthen, A. Zimmer The opioid peptides enkephalin and β-endorphin in alcohol addiction Biol. Psychiatry (2008) 1;64(11):989-97.

21. Gertsch, J. M. Leonti, S. Raduner, I. Racz, J-Z Chen, X-Q Xie, K-H Altmann, M. Karsak, A. Zimmer Beta-Caryophyllene is a Dietary Cannabinoid PNAS (2008) 105(26):9099-104.

22. Bilkei-Gorzo A., I. Racz, K. Michel, D. Mauer, A. Zimmer, D. Klingmüller, A. Zimmer Control of hormonal stress reactivity by the endogenous opioid system. Psychoneuroendocrinology (2008) 33, 425–436.

23. Bilkei-Gorzo A, Racz I, Michel K, Darvas M, Maldonado R, Zimmer A. A Common Genetic Predisposition to Stress Sensitivity and Stress-Induced Nicotine Craving. Biol Psychiatry. (2008) 15;63(2):164-71.

24. Bailey A, Yoo JH, Racz I, Zimmer A, Kitchen I. Preprodynorphin mediates locomotion and D(2) dopamine and mu-opioid receptor changes induced by chronic 'binge' cocaine administration. J Neurochem. 2007 Sep;102(6):1817-30.

25. Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Muller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, de Angelis MH. Introducing the German Mouse Clinic: open access platform for standardized phenotyping.Nat Methods. 2005 Jun;2(6):403-4.

26. Rodd ZA, Anstrom KK, Knapp DJ, Racz I, Zimmer A, Serra S, Bell RL, Woodward DJ, Breese GR, Colombo G. Factors mediating alcohol craving and relapse: stress, compulsivity, and genetics. Alcohol Clin Exp Res. 2005 Jul;29(7):1325-33.

a) Bilkei-Gorzo, I. Racz, O. Valverde, M. Otto, K. Michel, M. Sarstre and A. Zimmer Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors PNAS 102 (43):15670-15675 (2005).

27. Racz I, Schutz B, Abo-Salem OM, Zimmer A (2005) Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice. Neuroreport 16:2025-2028.

29. Racz I, Bilkei-Gorzo A, Toth ZE, Michel K, Palkovits M, Zimmer A. A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. J. Neurosci. 2003 Mar 15;23(6):2453-8.

30. Bardos G, Moricz K, Jaszlits L, Rabloczky G, Tory K, Racz I, Bernath S, SumegiB, Farkas B, Lierati-Nagy B, Literati-Nagy P. BGP-15, a hydroximic acid derivative, protects against cisplatin- or taxol-induced peripheral neuropathy in rats. Toxicol. Appl. Pharmacol. 2003 Jul 1;190(1):9-16.

31. Hamar J, Racz I, Ciz M, Lojek A, Pallinger E, Furesz J. Time course of leukocyte response and free radical release in an early reperfusion injury of the superior mesenteric artery Physiol. Res. 2003;52(4):417-23.

32. Racz I, Tory K, Gallyas F Jr, Berente Z, Osz E, Jaszlits L, Bernath S, Sumegi B, Rabloczky G, Literati-Nagy P. BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem Pharmacol. 2002 Mar 15;63(6):1099-111.

33. Bilkei-Gorzo A, Racz I, Michel K, Zimmer A. Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene. J. Neurosci. 2002 Nov 15;22(22):10046-52.