Dr. Roberto Bei

Department of Experimental Medicine and Biochemical Sciences

University of Rome, Italy

Associate Professor

Email: bei@med.uniroma2.it

Qualifications

1998 Ph.D., University of Rome La Sapienza

1989 M.D., University of Rome La Sapienza

Publications (Selected)

1. Masuelli L, Marzocchella L, Focaccetti C, Tresoldi I, Palumbo C, Izzi V, Benvenuto M, Fantini M, Lista F, Tarantino U, Modesti A, Galvano F, Bei R. “Resveratrol and Diallyl disulfide potentiate curcumin-induced apoptosis in rabdomyosarcoma and osteosarcoma cell lines”. Front Biosci.-Landmark Ed. 17: 498-508, 2012.
2. Izzi V, Masuelli L, Tresoldi I, Sacchetti P, Modesti A, Galvano F, Bei R. “The effects of dietary flavonoids on the regulation of redox inflammatory networks. Front Biosci.-Landmark Ed. 17: 2396-2418, 2012.
3. Bei R, Palumbo C, Masuelli L, Turriziani M, Frajese GV, Li Volti G, Malaguarnera M, Galvano F. “Impaired expression and function of cancer-related enzymes by anthocyans: an update”. Curr. Enzyme Inhib. 8: 2-21, 2012.
4. Masuelli L, Budillon A, Marzocchella L, Mrozek M-A, Vitolo D, Di Gennaro E, Losito S, Sale P, Longo F, F, Lista F, Muraro R, Modesti A and Bei R. “Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/α-β catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas”. J. Cell Physiology 227: 3344-53, 2012.
5. Izzi V, Masuelli L, Tresoldi I, Foti C, Modesti A and Bei R. “Immunity and malignant mesothelioma: From mesothelial cell damage to tumor development and immune-response-based therapies”. Cancer Letters 32:18-34, 2012.
6. Turriziani M, Fantini M, Benvenuto M, Izzi V, Masuelli L, Sacchetti P, Modesti A, Bei R. “Carcinoembryonic Antigen (CEA)-Based Cancer Vaccines: Recent Patents and Antitumor Effects from Experimental Models to Clinical Trials”. Recent Pat Anticancer Drug Discov. 7: 265-296, 2012.
7. Giganti MG, Liuni F, Celi M, Gasbarra E, Zenobi R, Tresoldi I, Modesti A, Bei R and Tarantino U. “Changes in serum levels of TNF-alpha, IL-6, OPG, RANKL and their correlation with radiographic and clinical assesment in fragility fractures and high energy fractures”. Journal of Biological Regulators & Homeostatic Agents 26: 671-680, 2012.
8. Faggioni G, Pomponi A, De Santis R, Masuelli L, Ciammaruconi A, Monaco F, Di Gennaro A, Marzocchella L, Sambri V, Lelli R, Rezza G, Bei R and Lista F. “West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals”. Virol J 9 (1): 283, 2012.
9. Bei R. Are Alpha-Fetoprotein Based-Vaccines Potential Tools for Liver Cancer Therapy. J Liver 2013, 2: e103. (Editorial).
10. Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N. “Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans”. Exp Gerontol. 48: 191-201, 2013.
11. Ingrosso G, Fantini M, Nardi A, Benvenuto M, Sacchetti P, Masuelli L, Ponti E, Frajese GV, Lista F, Schillaci O, Santoni R, Modesti A and Bei R. “Local radiotherapy increases the level of autoantibodies to ribosomal P0 protein but not to heat shock proteins, extracellular matrix molecules and EGFR/ErbB2 receptors in prostate cancer patients”. Oncology Reports 29: 1167-1174, 2013.
12. Izzi V, Chiurchiù V, Doldo E, Palumbo C, Tresoldi I, Bei R, Albonici L. and Modesti A. “Interleukin-17 produced by malignant mesothelioma-polarized immune cells promotes tumor growth and invasiveness”. Eur J Inflammation 11: 203-214, 2013.
13. Masuelli L, Benvenuto M, Fantini M, Marzocchella L, Sacchetti P, Di Stefano E, Tresoldi I, Izzi V, Bernardini R, Palumbo C, Mattei M, Lista F, Galvano F, Modesti A and Bei R.  “Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary Tumors in neu transgenic mice”. Journal of Biological Regulators & Homeostatic Agents 27: 105-119, 2013.
14. Grosso G, Bei R, Mistretta A, Marventano S, Calabrese G, Masuelli L, Giganti MG, Modesti A, Galvano F, Gazzolo D. “Effects of Vitamin C on health: a review of evidence”. Front Biosci.-Landmark Ed. 18: 1017-1029, 2013.
15. Benvenuto M, Fantini M, Masuelli L, De Smaele E, Zazzeroni F, Tresoldi I, Calabrese G, Galvano F, Modesti A, Bei R. “Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer”. Front Biosci.-Landmark Ed. 18, 1290-1310, 2013.
16. Farina A, Santarelli R, Bloise R, Gonnella R, Granato M, Bei R, Modesti A, Cirone M, Bengtsson L, Angeloni A, and Faggioni A. KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution. Virus Research 175, 143-150, 2013.
17. Bei R, Romano M, Caputo MP, Sconocchia G, Capuani B, Coppola A, Nucci C, Pastore D, Bellia A,  Mancino R, Andreadi K, Cerilli M, Bertoli A, Modesti A and Lauro D. “A survey of autoantibodies to self antigens in Graves’ disease patients with thyroid associated ophthalmopathy“. Eur J Inflammation  11: 539-546, 2013.
18. Tresoldi I, Oliva F, Benvenuto M, Fantini M, Masuelli L, Bei R, Modesti A. Tendon's ultrastructure. Muscles Ligaments Tendons J. 3(1): 2-6, 2013.
19. Izzi V, Buler M, Masuelli L, Giganti MG, Modesti A and Bei R.”Poxvirus-Based Vaccines for Cancer Immunotherapy: New Insights from Combined Cytokines/Co-Stimulatory Molecules Delivery and “Uncommon” Strains”. Anti-Cancer Agents in Medicinal Chemistry, 14: 183-189, 2014.
20. Tresoldi I, Foti C, Masuelli L, Frajese G, Rossi P, Modesti A, Bei R, and Giganti M. Effects of Dragon Boat Training on Cytokine Production and Oxidative Stress in Breast Cancer Patients: A Pilot Study. Open Journal of Immunology, 4, 22-29. 2014
21. Masuelli L, Fantini M, Benvenuto M, Sacchetti P, Giganti MG, Tresoldi I, Lido P, Lista F, Cavallo F, Nanni P, Schlom J, Modesti A, Bei R. Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells. J Transl Med. 12: 122, 2014.
22. Giganti MG, Tresoldi I, Masuelli L, Modesti A, Grosso G, Liuni FM, Celi M, Rao C, Gasbarra E, Bei R, Tarantino U. Fracture healing: From basic science to role of nutrition. Front Biosci (Landmark Ed). 19: 1162-75, 2014.
23. Ceccarelli S, Bei R, Vescarelli E, D'Amici S, di Gioia C, Modesti A, Romano F, Redler A, Marchese C, Angeloni A. Potential Prognostic and Diagnostic Application of a Novel Monoclonal Antibody Against Keratinocyte Growth Factor Receptor. Mol Biotechnol. 2014 Oct; 56(10): 939-52.
24. Faggioni G, De Santis R, Pomponi A, Fantini M, Savini G, Monaco F, Polci A, Bei R and Lista F. Rapid molecular detection and genotyping of West Nile Virus lineages 1 and 2 by Real Time PCR and Melting Curve Analysis. Journal of Virological Methods. 2014 Oct; 207: 54-59.
25. Masuelli L, Di Stefano E, Fantini M, Mattera R, Benvenuto M, Marzocchella L, Sacchetti P, Focaccetti C, Bernardini R, Tresoldi I, Izzi V, Mattei M, Frajese GV, Lista F, Modesti A, and  Bei R. Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget. 2014; 5(21): 10745-62
26. Tarantino U, Piccirilli E, Fantini M, Baldi J, Gasbarra E, Bei R. Sarcopenia and fragility fractures: molecular and clinical evidence of the bone-muscle interaction. Journal of Bone and Joint Surgery. 2015; 97(5): 429-437.
27. Benvenuto M, Sileri P, Rossi P, Masuelli L, Fantini M, Nanni M, Franceschilli L, Sconocchia G, Lanzilli G, Arriga R, Faggioni G, Lista L, Orlandi A, Manzari V, Gaspari A, Modesti A, Bei R. Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients. J Transl Med 2015, 13: 101.
28. Fantini M, Benvenuto M, Masuelli L, Frajese GV, Tresoldi I, Modesti A and Bei R. In Vitro and In Vivo Antitumoral Effects of Combination of Polyphenols or Polyphenol/s and Anticancer Drugs: Perspectives on Cancer Treatment. Int J Mol Sci. 2015; 16: 9236-9282.
29. De Amicis A, De Sanctis S, Di Cristofaro S, Franchini V, Lista F, Regalbuto E, Giovenale E, Gallerano GP, Nenzi P, Bei R, Fantini M, Benvenuto M, Masuelli L, Coluzzi E, Cicia C, Antonella Sgura A. Biological effects of in vitro THz radiation exposure in human foetal fibroblasts. Mutation Research (Genetic Toxicology and Environmental Mutagenesis). 2015. In press.
30. Frajese GV, Benvenuto M, Fantini M, Ambrosin E, Sacchetti P, Masuelli L, Giganti MG, Modesti A and Bei R. Potassium increases the in vitro antitumor effects of ascorbic acid in breast cancer cell lines. Oncology Rep. 2015. In press