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Biography

Prof. Jian Li

Monash University, Australia

 

Email: Jian.Li@monash.edu

 

Qualifications

 

2002  Ph.D., University of South Australia, Australia

1999  M.Sc., Shandong University, China

1996  B.Sc., Shandong University, China

 

Publications (Selected)

  1. Li, J., Coulthard, K., Milne, R.W., Nation, R.L., Conway, S., Peckham, D., Etherington, C., and Turnidge, J.D. Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis. Journal of Antimicrobial Chemotherapy. 2003, 52(6):987-992.
  2. Li, J., Nation, R.L., Milne, R.W., Turnidge, J.D., Smeaton, T.C., and Coulthard, K. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. Journal of Antimicrobial Chemotherapy. 2004, 53:837-840.
  3. Li, J., Rayner, C.R., Nation, R.L., Owen, R.J., Spelman, D., Tan, K.E. and Liolios L. Hetero-resistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 2006, 50(9):2946-2950.
  4. Li, J., Nation, R.L., Turnidge, J.D., Milne, R.W., Coulthard, K., Rayner, C.R. and Paterson, D.L. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. The Lancet Infectious Diseases. 2006, 6:589-601.
  5. Li, J., Nation, R.L., Owen, R.J., Wong, S., Spelman, D. and Franklin, C. Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of colistin-resistant strains. Clinical Infectious Diseases. 2007, 45(5):594-598.
  6. Zavascki, A.P., Goldani, L.Z., Cao, G.Y., Superti, S.V., Lutz, L., Barth, A.L., Ramos, F., Boniatti, M.M., Nation, R.L., Li, J. Pharmacokinetics of intravenous polymyxin B in critically-ill patients. Clinical Infectious Diseases. 2008, 47(10):1298-1304.
  7. Soon, R., Nation, R.L., Hartley, P.G., Larson, I. and Li, J. Atomic force microscopy investigation of the morphology and topography of colistin hetero-resistant Acinetobacter baumannii as a function of growth phase, and in response to colistin treatment. Antimicrobial Agents and Chemotherapy. 2009, 53(12):4979-4986.
  8. Velkov, T., Thompson, P., Nation, R.L. and Li, J. Structure-activity relationships of polymyxin antibiotics. Journal of Medicinal Chemistry. 2010, 53(5):1898-1916.
  9. Dudhani, R.V., Turnidge, J.D., Nation, R.L. and Li, J. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic Index of colistin against Acinetobacter baumannii in murine thigh and lung infection models. Journal of Antimicrobial Chemotherapy. 2010. 65(9):1984-1990.
  10. Moffatt, J.H., Harper, M., Harrison, P., Hale, J.D.F., Vinogradov, E., Seemann, T., Henry, R., Crane, B., Michael, F. St., Cox, A.D., Adler, B., Nation, R.L., Li, J. and Boyce, J.D. Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide. Antimicrobial Agents and Chemotherapy. 2010. 54(12):4971-4977.
  11. Soon, R., Velkov, T., Chiu, F., Thompson, P.E., Roberts, K., Larson, I., Nation, R.L. and Li, J. Design, synthesis and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions. Analytical Biochemistry. 2011. 66(1):126-133.
  12. Sandri, A.M., Landersdorfer, C.B., Jacob, J., Boniatti, M.M., Dalarosa, M.G., Falci, D.R., Behle, T.F., Bordinhão, R.C., Wang, J., Forrest, A., Nation, R.L., Li, J., Zavascki AP. Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clinical Infectious Diseases. 2013 57(4):524-531.
  13. Azad, M.A.K., Finnin, B.A., Poudyal, A., Davis, K., Li, J.H., Hill, P.A., Nation, R.L., Velkov, T., Li, J. Polymyxin B induces apoptosis in kidney proximal tubular cells. Antimicrobial Agents and Chemotherapy. 2013. 57(9):4329-4335.
  14. Velkov, T., Roberts, K.D., Nation, R.L., Wang, J., Thompson, P.E., Li, J. Teaching ‘old’ polymyxins new tricks: New-generation lipopeptides targeting Gram-negative ‘superbugs’. ACS Chemical Biology. 2014. 9(5):1172-1177.
  15. Henry, R., Crane, B., Powell, D., Deveson Lucas, D., Li, Z., Aranda, J., Harrison, P., Nation, R.L., Adler, B., Harper, M., Boyce, J.D., Li, J. The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model. Journal of Antimicrobial Chemotherapy. 2015. 70(5):1303-1313.
  16. Azad, M.A., Roberts, K.D., Yu, H.H., Liu, B., Schofield, A.V., James, S.A., Howard, D.L., Nation, R.L., Rogers, K., de Jonge, M.D., Thompson, P.E., Fu, J., Velkov, T., Li, J. Significant accumulation of polymyxin in single renal tubular cells: A medicinal chemistry and triple correlative microscopy approach. Analytical Chemistry. 2015. 87(3):1590-1595.