Dr. Mei-Zhen Cui

University of Tennessee, USA



1990 Ph.D., Molecular Biology, Tokyo Institute of Technology, Japan

1985 M.Sc., Biochemistry, Jilin University, China

1982 B.Sc., Chemistry, Jilin University, China

Publications (Selected)

  1. Wu, DD, Zhang, F, Hao, F, Chun, J, Xu, X and Cui, M.-Z., Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and Integrin Pathways Leading to Cell Migration, J. Biol. Chem. 2014, 289(9): 5774-5783.
  2. Li, Ting, Zeng, L., Gao, W., Cui, M.-Z., Fu, X. and Xu, X. PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins. Biochim Biophys Acta- Molecular Basis of Disease. 2013 Mar;1832(3):453-74.
  3. Shi, J., Dong, Y., Cui, M.-Z. and Xu, X., Lysophosphatidic acid induces increased BACE1 expression and Abeta formation, Accepted for publication on Biochim Biophys Acta- Molecular Basis of Disease, 2013, Jan;1832(1):29-38.
  4. Hao, F., Wu, DD. Xu, X. and Cui, M.-Z., Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells. American Journal of Physiology-Heart and Circulatory Physiology, 2012, 303(11):H1344-52.
  5. Mao, G, Cui M.-Z, Li, T, Jin, Y, Xu, X. Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment. J. Neurochem. 2012,123(5):837-44.
  6. Zeng L, Li T, Xu DC, Liu J, Cui M-Z, Fu X, Xu X. Death Receptor 6 Induces Apoptosis Not through Thype I or Type II Pathways, but via a Unique Mitochondria-dependent Pathway by Interacting with Bax Protein. J. Biol. Chem. 2012, 287(34):29125-33.
  7. Takuya, I., Zhang, F., Sun, L., Hao, F., Schmitz, C., Xu, X. and Cui, M.-Z., Lysophosphatidic Acid Induces Early Growth Response-1 (Egr-1) Protein Expression via Protein Kinase Cδ-regulated Extracellular Signal-regulated Kinase (ERK) and c-Jun N-terminal Kinase (JNK) Activation in Vascular Smooth Muscle Cells. J. Biol. Chem. 2012, 287: 22635-22642.
  8. Cui, M.-Z., (review) Lysophosphatidic acid effects on atherosclerosis and thrombosis. Clinical Lipidology, 2011, 6(4), 413-426.
  9. Wang, K., Cai, L., Hao, F., Xu, X., Cui, M.-Z., Wang, S., Distinct Cell Responses to Substrates Consisting of Poly(ε-caprolactone) and Poly(propylene fumarate) in the Presence or Absence of Crosslinks. Biomacromolecules, 2010, 11(10):2748-2759.
  10. Hao, F. Tan, M. Wu, D. Xu, X. and Cui, M.-Z., Lysophosphatidic acid induction of interleukin 6 secretion from aortic smooth muscle cells via LPA1 regulated, PKC dependent and p38alpha mediated pathway, American Journal of Physiology-Heart and Circulatory Physiology, 2010, 298(3):H974-983.
  11. Tan, J., Mao, G., Cui, M.-Z. Lamb, B., Sy, M.-S. and Xu, X. Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta amyloid peptide. Neurobiology of Disease. 2009, 36(3):453-460.
  12. Mao, G., Tan, J., Cui, M.-Z. Chui, D. and Xu, X. The GxxxG Motif in the Transmembrane Domain of AβPP Plays an Essential Role in the Interaction of CTFb with the γ-secretase Complex and the Formation of Ab. Journal of Alzheimer’s Disease, 2009, 18(1):167-176.
  13. Tan, M., Hao, F., Xu, X., Chisolm, G. and Cui, M.-Z., Lysophosphatidylcholineactivates a novel PKD2-mediated signaling pathway that controls monocytic THP-1 cell migration, Arterioscler Thromb Vasc Biol., 2009, 29:1376-1382.
  14. Tan, J., Mao, G., Cui M.-Z., Kang, S.C., Lamb, B., Wong, B.S., Sy, M.S., Xu, X. Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model. J. Neurochem., 2008, 107, 722-733.
  15. Hao, F., Tan, M., Xu, X., and Cui, M.-Z., Histamine Induces Egr-1 Expression in Human Aortic Endothelial Cells via the H1 Receptor-mediated Protein Kinase C?-Dependent ERK Activation Pathway, J. Biol. Chem., 2008, 283(40): 26928–26936.
  16. Mao, G., Dong, Y., Tan, J., Cui, M. Z. and Xu, X.Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP, Biochim Biophys Acta-gen subjects, 2008, 1780(4):696-708.
  17. Hao, F., Tan, M., S., Xu, X., Han, J., Miller, D., Tigyi, G. and Cui, M.-Z., Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38, Biochim Biophys Acta-Mol and Cell Bio Lipid, 2007, 1771: 883-892.
  18. Zhao, G., Tan, J., Mao, G., Cui, M.-Z., and Xu, X., The sequential relationship of themulti intramembrane cleavages of APP suggests a single enzyme model, J. Neurochem, 2007, 100: 1234-1246.
  19. Cui, M. Z., Laag, E., Sun, L., Tan, M., Zhao G., and Xu, X., Lysophosphatidic Acid Induces Early Growth Response Gene 1 Expression in Vascular Smooth Muscle Cells, CRE and SRE Mediate the transcription, Artherioscler, Thromb and Vasc Biol., 2006, 26: 1029-1035.
  20. Xie, Z., Dong, Y., Zhang, M., Cui, M. Z., Cohen, R.. Riek, U., Neumann, D., Schlattner, U., Zou, M.-H. Activation of Protein kinase C-zetaby Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinasein Cultured Endothelial Cells. J. Biol. Chem., 2006, 281(10): 6366 –6375.
  21. Dong, Y., Tan, J. Cui, M. Z., Zhao, G.,Mao, G. Singh, N. and Xu, X., Calpain inhibitor MDL28170 modulates A? formation by inhibiting the formation of intermediate A? 46 and protecting A? from degradation. The FASEB Journal, 2006, 20: 331-333.
  22. Zhao, G., Cui M.-Z., Mao, G., Tan, J,, Dong Y, Sun, L. and Xu, X. (2005), cleavage is dependent on-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J. Biol. Chem., 2005, 280(45): 37689-37697.
  23. Zhao G, Mao G, Tan J, Dong Y, Cui M.-Z., Kim SH, Xu X. Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem., 2004, 279(49): 50647-50650.
  24. Liang, SL, Cui, M.-Z., Penn MS, Chisolm, GM. Oxidized lipoprotein regulation of tissue factor in smooth muscle cells. International Congress Series 2004, 1262: 83-86.
  25. Tan, M., Xu, X., Ohba, M. and Cui, M.-Z., Protein kinase C delta mediates Angiotensin II-induced protein kinase D phosphorylation in aortic smooth muscle cells. Artherioscler, Thromb and Vasc Biol. 2004, 24:2271-2276.
  26. Cui, M.-Z. and Xu, X., (invited commentary) Lysophosphatidic Acid, Tissue Factor and Atherosclerosis, 2003, at:
  27. Tan, M., Xu, X., Ohba, M., Ogawa W. and Cui, M.-Z., Thrombin rapidly induces protein kinase D phosphorylation and protein kinase C delta mediates the activation. J. Biol. Chem., 2003, 278(5): 2824-2828.
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