Dr. Steven N. Fiering
Dartmouth Medical School, USA
Email: Fiering@Dartmouth.edu
Qualifications
1990 Ph.D., Stanford University
1985 M.Sc., Eastern Michigan University
1974 B.Sc., University of Michigan
Publications (Selected)
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Hug, B. A., R. L. Wesselschmidt, S. Fiering, M. A. Bender, E. Epner, M. Groudine, T.J. Ley; Analysis of Mice Containing a Targeted Deletion of ß-globin Locus Control Region 5’ Hypersensitive Site 3; Molecular and Cellular Biology, 16, 2906-2912, 1996.
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Walters, M., W. Magis, S. Fiering, J. Eidemiller, D. Scalzo, M. Groudine; Transcriptional Enhancers Act to Suppress Position Effect Variegation in Cis; Genes and Development, 10, 185-196, 1996.
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Diecken, E., E.Epner, S. Fiering, K. Fournier, M. Groudine; Efficient Gene Targeting of the Human ß-globin in Recombination-Proficient Chicken/Human Microcell Hybrids; Nature Genetics, 12, 174-182, 1996.
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Magis, W., S. Fiering, M. Groudine, D. I. K. Martin; An Upstream Activator of transcription Coordinately Increases the Level and Epigenetic Stability of Gene Expression; Proceedings of the National Academy of Sciences USA, 93: 13914-13918, 1996.
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Zambrowicz, B. P., A. Imamoto, S. Fiering, L. A. Herzenberg, W. G. Kerr, P. Soriano; Disruption of Overlapping Transcripts in the ROSA ßgeo 26 Gene Trap Strain Leads to Widespread Expression of ß-galactosidase in Mouse Embryos and Hematopoietic Cells; Proceedings of the National Academy of Sciences USA, 94: 3789-3794, 1997.
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Garrick, D., S. Fiering, D. I. K. Martin, E. Whitelaw; Cremediated Reduction of Copies within a Transgene Array Provides Evidence for Repeat-induced Gene Silencing in Mammals; Nature Genetics 18:56-59, 1998.
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Seibler, J., D. Schubeler, S. Fiering, M. Groudine, J. Bode; DNA Cassette Exchange in ES cells Mediated by FLP Recombinase: An Efficient Strategy for Repeated Modification of Tagged Loci by Marker-free Constructs; Biochemistry, 37:6229-6234, 1998.
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Ley, T. J., B. Hug, S. Fiering, E. Epner,. M. A. Bender, M. Groudine; Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5’ HS-2 or 5’ HS-3; Annals of the New York Academy of Sciences, 850:45-53, 1998.
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Epner, E, A. Reik, D. Cimbora, A. Telling, M. A. Bender, S. Fiering, T. Enver, D. I. K. Martin, M. Kennedy, G. Keller, M. Groudine; The ß-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse ß-globin locus; Molecular Cell 2:447-455, 1998.
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Bender, M. A., A. Reik, J. Close, A. Telling, E. Epner, S. Fiering, R. Hardison, M. Groudine; Description and targeted deletion of 5’ hypersensitive site 5 and 6 of the mouse ß-globin locus control region; Blood, 92:4394-4403, 1998.
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Howell, AL, T. N. Thacker, F. Li, S. Fiering, R. F. Graziano, J. Goldstein, and M. W. Fanger. Targeting HIV-1 gp120 to the high affinity Fc receptor (FcgRI, CD64) on myeloid antigen presenting cells: implications for enhancing vaccine responses. Current Topics in Virology 1:62-70, 1999.
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Feng Y-Q, J. Seibler, R. Alami, A. Eisen, K. A. Westerman, P. Leboulch, S. Fiering, E. Bouhassira; Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange. Journal of Molecular Biology, 292: 779-785, 1999.
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Alami, R., J. M. Greally, K. Tanimoto, S. Hwang, Y.Q. Feng, J.D. Engel, S. Fiering, E. Bouhassira; The ß-globin LCR controls expression levels but does not block heterocellular position effects. Human Molecular Genetics 9:631-6, 2000.
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Alami, R., M. A. Bender, Y-Q. Feng, T. J. Ley, S. Fiering, M. Groudine, EE Bouhassira; Deletions within the mouse ß-globin LCR preferentially reduce ß-minor expression. Genomics 63:417-424, 2000.
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Bender, M. A., M.G. Mehaffey, A. Telling, B. Hug, T.J. Ley, M. Groudine, S. Fiering; Independent formation of DNaseI hypersensitive sites in the murine ß-globin locus control region. Blood, 95:3600-4, 2000.
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Feng, YQ, M. Lorincz, S. Fiering, J.M. Greally, E.E. Bouhassira;Position effects are influenced by the orientation of a transgene with respect to flanking chromatin. Molecular and Cellular Biology, 21, 298-309, 2001.
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Bender, MA, J. N. Roach, J. Halow, J. Close, R. Alami, E. E. Bouhassira, M. Groudine, S. Fiering; Targeted deletion of 5’HS1 and 5’HS4 of the ß-globin LCR reveals additive activity of DnaseI hypersensitive sites, Blood (plenary paper), 98, 2022-7, 2001
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Schneider, MJ, S. Fiering, S. E. Pallud, A.E. Parlow, D. L. St. Germain, V. A. Galton; Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in phenotype of pituitary resistance to thyroxine, Molecular Endocrinology, 15, 2137-48, 2001.
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Eszterhas, S, D. I. K. Martin, E.E. Bouhassira, S. Fiering; Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position, Molecular and Cellular Biology 22:469-79, 2002.
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Krieser, R.J., KS. MacLea, DS Longnecker, JL Fields, S. Fiering and A. Eastman. Deoxyribonuclease IIa is required for DNA digestion during the phagocytic phase of apoptosis and its loss causes perinatal lethalality, Cell Death Different., 9: 956-962, 2002.
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Hernandez, A., S. Fiering, E. Martinez, V.A. Galton, D. St.Germain;The gene locus encoding idothyroxine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology, 143:4483-6, 2002.
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Hu, X., M. Bulger, J.N. Roach, S.K. Eszterhas, E. Olivier, E.E. Bouhassira, M. Groudine, S. Fiering; Promoters of the murine embryonic ß-like globin genes Ey and ßh1 do not compete for interaction with the ß-globin locus control region. Proceedings of the National Academy of Sciences USA 100:1111-5, 2003.
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Sutter, N.B., D. Scalzo, S. Fiering, M. Groudine, D. I. K. Martin; Chromatin insulation by a transcriptional activator. Proceedings of the National Academy of Sciences USA 100:1105-10, 2003.
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Rosenbauer, F., K. Wagner, J.L. Kutok, H. Iwasaki, M. LeBeau, Y. Okuno, K. Akashi, S. Fiering, D.G. Tenen, Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1. Nature Genetics, 36: 624-30, 2004.
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Kato, KC, S. Martinez, P. Russel, Nurden, A. Nurden, S. Fiering, J. Ware; Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood, 104: 2339-44, 2004.
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Kang, HC, JH Chae, YH Lee, M-A Park,JH Shin, S-H Kim, S-K Ye, YS Cho, S Fiering, CG Kim; Erythroid cell specific a-globin gene regulation by the CP2 transcription factor family. Molecular and Cellular Biology, 25:6005-20, 2005.
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Schneider, M., S. Fiering, B. Thai, S-Y Wu, E St. Germain, AF Parlow, DL St. Germain, VA Galton; Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology, 147:580-9, 2006.
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Hernandez, A, ME Martinez, S Fiering, VA Galton, D St. Germain: Type 3 deiodinase is critical for the maturation and function of the thyroid axis. Journal of Clinical Investigation, 116:476-84, 2006.
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Hu, X, M. Bulger, M. A. Bender, J. Fields, M. Groudine, S. Fiering: Deletion of the core region of 5’HS2 of the mouse ß-globin locus control region reveals a distinct effect in comparison with human ß-globin transgenes. Blood, 107:821-6, 2006.
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Hu, X, Eszterhas, S, Pallazzi, N, Bouhassira, EE, Fields, J, Tanabe, O, Gerber, SA. Bulger, M, Engel JD, Groudine, M, Fiering, S: Transcriptional Interference among the murine-like globin genes. Blood 109:2210-2216, 2007.
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Barre, L, C. Richardson, M. F. Hirshman, J. Brozinick, S. Fiering, B. E. Kemp, L. J. Goodyear,L.A. Witters A genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.American Journal of Physiology: Endocrinology and Metabolism 292: E802-E811, 2007.
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Ma, Y, S. Fiering, C. Black, X. Liu, Z. Yuan, V. A. Memoli, D. J. Robbins, H. A. Bentley, G. J. Tsongalos, E. Dimidenko, S. J. Freemantle, E. Dmitrovsky. Transgenic Cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proceedings of the National Academy of Sciences USA, 104:4089-94, 2007.
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Hsu, Y. M., R. Mabaera, C. H. Lowrey, D. I. K. Martin, S. Fiering. CpG hypomethylation inlarge domain encompassing the embryonic eta-like globin genes in primitive erythrocytes. Molecular and Cellular Biology 27:5047-54, 2007.
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Srinivasulu, S., S. A. Acharya, M. Prabhakaran, M.E. Fabry, R. Alami, S. Fiering, E. E. Bouhassira, R.L. NagelHbS-Savaria: The antipolymerization effect of a single mutation in human alpha-chains. Protein Journal. 26: 523-32, 2007.
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Jain, S, Vinukonda, G, Fiering, SN, Kumar, A: A halotype of human angiotensinogen gene containing-217A increases blood pressure in transgenic mice as compared to 217G. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 295(6):R1849-57, 2008.
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Hsu, M, C. A. Richardson, E. Olivier, C. Qui, E. E. Bouhassira, C. H. Lowrey, S. Fiering: Complex developmental patterns of histone modifications associated with the human eta-globin switch in primary cells. Experimental Hematology. 37:799-806, 2009.
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Coon, C. I., S. Fiering, J. Gaudet, C.A. Wyatt, C. E. Brinckerhoff: Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP, Matrix Biology 28:425-31 (2009).
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Fromm, G., C. de Vries, R. Byron, J. Fields, S. Fiering, M. Groudine, M. A. Bender, J. Palis, and M. Bulger: Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression. Blood, 114:3479-88 (2009).
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Guan, Z., C. M. Hughes, S. Kosiyatrukul, P. Norio, R. Sen, S. Fiering, C. D. Allis, E. E, Bouhassira, C. L. Schildkraut. Decreased replication origin activity in temporal transition regions. Journal of Cell Biology 187:623-35 (2009).
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Liu, X, L. F. Sempere, F. Galimberti, S.J. Freemantle, C. Black, K. H. Dragnev, Y. Ma, S. Fiering, V. Memoli. J. Li, S. Kauppinen E. Dmitrovsky: Uncovering Growth-Suppressive MicroRNAs in Lung Cancer. Clinical Cancer Research 15: 1177-83, (2009).
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Crane-Godreau, M, M.M. Maccani, S.K.Eszterhas, S.L. Warner, J.A. Jukosky, S. Fiering: Exposure to cigarette smoke disrupts CCL20-mediated antimicrobial activity in respiratory epithelial cells. Open Immunology Journal 2: 86-93, (2010).
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Lathrop, MJ, L Chakrabarti, J Eng, CH Rhodes, T. Lutz, A. Nieto, HD. Liggitt, S Warner, J. Fields, R. Stoger, S. Fiering: Deletion of the Chd6 exon 12 affects motor coordination. Mammalian Genome 3-4: 130-42 (2010).
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Akada, H, D. Yan, H. Zou, S. Fiering, RE Hutchinson, MG Mohi:Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood, 115: 3589-97, (2010).
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Berland, R., S. Fiering, H. Wortis: A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells. Journal of Immunology 185:7537-43, (2010).
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Jain, S., A. Tillinger, B. Mopidevi, VG Pandey, C Chauhan, S Fiering, S Warming, A. Kumar: Transgenic mice with -6A haplotype of the human angiotensinogen gene have increased blood pressure compared to -6G haplotype, Journal Biol. Chem, 285:41172-86, 2010.
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Fromm G, Cadiz-Rivera B, de Vries C, Getman M, McGrath KE, Kingsley PD, Fields J, Fiering S, Bulger M.; An embryonic stage-specific enhancer within the murine {beta}-globin locus mediates domain-wide histone hyperacetylation. Blood 117; 52-7-14 2011.