Dr. Olga Vinogradova

Department of Pharmaceutical Sciences, School of Pharmacy

Email: olga.vinogradova@uconn.edu

Qualifications

Publications (Selected)

1. C. R. Sanders, L. Czerski, O. Vinogradova, P. Badola, D. Song, and S.O. Smith, "E.Coli Diacylglycerol Kinase is ana-Helical Polytopic Membrane Protein and Can Spontaneously Insert into Preformed Lipid Vesicles”, Biochemistry 1996, 35, 8610-8618.
2. O. Vinogradova, P. Badola, L. Czerski, F.D. Sonnichsen, and C. R. Sanders, "E.Coli Diacylglycerol Kinase: A Case Study in the Application of Solution NMR Methods to an Integral Membrane Protein”,Biophysical J.1997, 72, 2688-2701.
3. O. Vinogradova, C. Carlin, F.D. Soennichsen, and C.R. Sanders, "A Membrane Setting for the Sorting Motifs Present in the Adeno virus E3-13.7 Protein which Down-Regulates the Epidermal Growth Factor Receptor", J. Biol. Chem.1998, 273, 17343-17350.
4. O. Vinogradova, F. Soennichsen, and C.R. Sanders, "On Choosing a Detergent for Solution NMR Studies of Membrane Proteins”, J. of BioMol. NMR 1998,4, 381-386.
5. L. Tsai, P.A. Szweda, O. Vinogradova, and L.I. Szweda, "Structural Characterization and Immunochemical Detection of a Fluorophore Derived from 4-Hydroxy-2-nonenal and Lysine”, Proc. Natl. Acad. Sci. USA 1998,95, 7975-7980.
6. O. Vinogradova, T. Haas, E.F. Plow, J. Qin, "Structural Basis for Integrin Activation by the Cytoplasmic Tail of the aIIb Subunit”, Proc. Natl. Acad. Sci. USA 2000, 97, 1450-1455.
7. L. Czerski, O. Vinogradova, C.R. Sanders, "NMR-Based Amide Hydrogen-Deuterium Exchange Measurements for Complex Membrane Proteins: Development and Critical Evaluation”, J. of. Mag. Res.2000, 142, 111-119.
8. O. Vinogradova, A. Velyvis, A. Velyviene, B. Hu, T. Haas, E.F. Plow, J. Qin, “A structural mechanism of integrin aIIbb3 “inside-out” activation as regulated by its cytoplasmic face”, Cell 2002, 110, 587-97.
9. A. Velyvis, J. Vaynberg, Y. Yang, O. Vinogradova, Y. Zhang, C. Wu, J. Qin, “Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling”, Nature Structural Biology 2003, 10(7), 558-64.
10. O. Vinogradova, J. Vaynberg, X. Kong, T. Haas, E.F. Plow, J. Qin, “Membrane-mediated structural transition at the cytoplasmic face during integrin activation”, Proc. Natl. Acad. Sci. 2004, 101, 4094-99.
11. J. Qin, O. Vinogradova, E.F. Plow, “Integrin bidirectional signaling: a molecular view”, PLoS Biol., 2004, 6, 726-9. Review.
12. J. Vaynberg, T. Fukuda, K. Chen, O. Vinogradova, A. Velyvis, Y. Tu, L. Ng, C. Wu, and J. Qin, “Structure of an Ultraweak Protein-Protein Complex and Its Crucial Role in Regulation of Cell Morphology and Motility”, Molecular Cell 2005, 17, 513-523.
13. Y. Mao, J. Yang, M. Pesho, O. Vinogradova, J. Qin, and E. Plow, “Regulation of Integrin AlphaIIbBeta3 Activation by Distinct Regions of its Cytoplasmic Tails”, Biochemistry 2006, 45, 6656-62.
14. L. Deshmukh, S. Tyukhtenko, J. Liu, J.E.B. Fox, J. Qin and O. Vinogradova, “Structural Insight into the Interaction between Platelet Integrin aIIbb3 and Cytoskeletal Protein Skelemin”, JBC 2007, 288, 32349-32356.
15. S. Tyukhtenko, L. Deshmukh, V. Kumar, J. Lary, J. Cole, V. Lemmon, O. Vinogradova, “Characterization of neuron specific L1-CAM cytoplasmic tail: Naturally disordered in solution it exercises different binding modes for different adaptor proteins”,Biochemistry 2008, 47, 4160-4168.
16. L. Deshmukh, L. Wu, R. P. Guttmann, O. Vinogradova, “NMR Structural Characterization of the Penta-Peptide Calpain Inhibitor”, FEBS Letters 2009, 583, 135-40.
17. J. M. Beierlein, L. Deshmukh, K. M. Frey, O. Vinogradova, A. C Anderson. “The Solution Structure of Bacillus anthracis Dihydrofolate Reductase Yields Insight into the Analysis of Structure-Activity Relationships for Novel Inhibitors”, Biochemistry 2009, 48, 4100-4108.
18. E. Tiburu, S. Tyukhtenko, L. Deshmukh, O. Vinogradova, D. Janero, A. Makriyannis, “Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments”, BBRC 2009, 384, 243-248.
19. S. Tyukhtenko,E. Tiburu, L. Deshmukh, O. Vinogradova, D. Janero, A. Makriyannis “NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: Candidate electrostatic interactions and microdomain formation”, BBRC 2009, 390, 441-446.
20. L. Deshmukh, V. Gorbatyuk, O. Vinogradova, “Integrin β3 Phosphorylation Dictates its Complex with Shc PTB Domain”, JBC 2010, 285, 34875-84.
21. L. Deshmukh, N. Meller, N. Alder, T. Byzova, O. Vinogradova, “Tyrosine Phosphorylation as a Conformational Switch: A Case Study of Integrin β3 Cytoplasmic Tail”, JBC 2011, in press (published on September 28 as Manuscript M111. 231951).
22. P. D. Bona, L. Deshmukh, V. Gorbatyuk, O. Vinogradova, D. A. Kendall, “Structural Studies of a Signal Peptide in Complex with Signal Peptidase I Cytoplasmic Domain: the Stabilizing Effect of Membrane-Mimetics on the Acquired Fold”, Proteins 2011.
23. X. Z. West, N. Meller, N. L. Malinin, L. Deshmukh, J. Meller, G.H. Mahabeleshwar, M.E. Weber, B.A. Kerr, O. Vinogradova, T.V. Byzova, “Integrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch”, PLos One 2012, 7, e31071.
24. R. Puthenveetil and O. Vinogradova, “Optimization of the Design and Preparation of Nanoscale Phospholipid Bilayers for its Application to Solution NMR”, Proteins2013, 81, 1222-1231.
25. P. Katyal, R. Puthenveetil and O. Vinogradova, “Structural Insights into the Recognition of β3Integrin Cytoplasmic Tail by SH3 Domain of Src Kinase”, Protein Science 2013, 22, 1358-65.
26. C. C. Hsiao, X. Lin, R.J. Barney, R. R. Shippy, J. Li, O. Vinogradova, D. F. Wiemer, and A. J. Wiemer, “Synthesis of a novel phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes”, Chemistry & Biology 2014, 21, 945–954.
27. V. Gorbatyuk, K. Nguyen, N. P. Podolnikova, L. Deshmukh, X. Lin, T. P. Ugarova and O.Vinogradova, “Skelemin Association with IIbβ3 Integrin: A Structural Model”,Biochemistry 2014,  53, 6766−6775.
28. X. Lin and O. Vinogradova, “Phospho-Tyrosine(s) vs. Phos­phatidylinositol Binding in Shc Mediated Integrin Signaling”, AJMB 2015, 5, 17-31.
29. Anand, M. LeDoyt, C. Karanian, A. Luthra, M. Koszelak-Rosenblum3, M. G. Malkowski,  R. Puthenveetil, O. Vinogradova, and J.D. Radolf “Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: Outer Membrane Insertion and Porin Function Requires a C-terminal β-barrel Domain”, JBC 2015.