Dr. Jing Zheng

Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine

Northwestern University, USA

Associate Professor

Email: jzh215@northwestern.edu

Qualifications

1992 Ph.D., Physiology, Michigan State University, USA

1985 M.Sc, Virology, Wuhan University, China

1982 B.Sc., Biology, Wuhan University, China

Publications (Selected)

1. Zheng, J., Furness, D., Duan, C., Miller, K.K., Edge, R.M., Chen, J., Homma, K., Hackney,C.M., Dallos, P., and Cheatham, M.A. Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti.Biology Open. 2(11) 1192-1202 (2013). PMCID: PMC3828766
2. Wong PC, Morgan-Short K, Ettlinger M, Zheng J., Linking neurogenetics and individual differences in language learning: The dopamine hypothesis. Cortex. 2012 48 (9):1091-1102. PMID: 22565204
3. Wong, C.M. P., Ettlinger, M., Zheng, J. Linguistic Grammar Learning and DRD2 TAQ-IA Polymorphism. PLoS One. 2013 May 31;8(5):e64983. PMID: 23741438
4. Homma, K., Duan, C., Zheng J., Cheatham, MA., Dallos P. Impairment of prestin’s fast motor kinetics by the V499G/Y501H mutation and its significance for defining functional independence of individual prestin subunits. J Biol Chem. (2013);288(4):2452-2463. doi: 10.1074/jbc.M112.411579. PubMed PMID: 23212912.
5. Cheatham, MA., Homma, K., Zheng J., Dallos P, What can prestin mouse models tell us about cochlear amplification? 2012, Proc. Auditory Res. Meeting, The Acoustical Society of Japan, Vol. 41
6. Wong, C.M. P., Chandrasekaran, B., Zheng, J. The Derived Allele of ASPM is Associated with Lexical Tone Perception. PloS One. 2012. 7 (4):e34243.
7. Zheng, J., Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, Scheetz TE,Drummond J, Scherer SE, Legan PK, Goodyear RJ, Richardson GP, Cheatham MA, Smith RJH, Dallos P. Carcinoembryonic antigen-related cell-cell adhesion molecule 16 interacts with α−tectorin and is mutated in autosomal dominant hearing loss (DFNA4). PNAS. 2011. Mar 8;108(10):4218-23.
8. Zheng L, Zheng J, Whitlon DS, García-Añoveros J, Bartles JR. Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model. J Neurosci. 2010 May 26;30(21):7187-201.
9. Sengupta S, Miller KK, Homma K, Edge R, Cheatham MA, Dallos P, Zheng J. Interaction between the motor protein prestin and the transporter protein VAPA. Biochim Biophys Acta-Molecular Cell Research. 2010 Jul;1803(7):796-804. PMC2878928.
10. Homma K, Miller KK, Anderson CT, Sengupta S, Du GG, Aguiñaga S, Cheatham M, Dallos P, Zheng J. Interaction between CFTR and prestin (SLC26A5). Biochim Biophys Acta-Biomembranes. 2010 Jun;1798(6):1029-40. PMC2862844.
11. Cheatham, MA., Low-Zeddies, S., Naik, K., Edge, R., Zheng, J., Anderson CT., Dallos, P.,A Chimera Analysis of Prestin knock-out Mice. J. Neurosci., 29(38):12000-12008., 2009.
12. Sengupta, S., George, M., Miller, KK., Naik, K., Chou, J., Cheatham, MA., Dallos, P., Naramura. M., Band, H., Zheng, J., EHD4 is an interacting partner for inner ear hair cell tiplink protein CDH23. J Biol Chem. 284(30):20121-9, 2009.
13. Zheng J, Anderson CT., Miller, KK., Cheatham, MA., Dallos, P., Identifying components of the hair-cell interactome involved in cochlear amplification BMC Genomics 10:127, 2009.
14. Dallos, P., Wu, X., Cheatham, MA., Gao, J., Zheng, J., Anderson, CT., Jia, S., Wang, X.,Cheng, HYW., Sengupta, S., He, DZZ., Zuo, J., Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron, May 8;58 (3):333-9, 2008.
15. Wu, X., Wang, X., Gao, J., Yu, Y., Jai, S., Zheng, J., Dallos, P., He, DZZ, Cheatham, MA.,Zuo, J., Glucose transporter 5 is not required for outer hair cell electromotility and cochlear amplification. Brain Research May 19;1210 :20-8, 2008.
16. Gao J, Wang X, Wu X, Aguinaga S, Huynh K, Jia S, Matsuda K, Patel M, Zheng J, Cheatham M, He DZ, Dallos P, Zuo J., Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. Proc Natl Acad Sci U S A, 30: 12542-12547, 2007.
17. Cheatham, M.A., Zheng, J., Huynh, K.H., Du, GG., Edge, R.M., Anderson, C.T., Zuo, J.,Ryan, A.F. and Dallos, P., Evaluation of an independent prestin mouse model derived from the 129S1 strain Audiology & Neurotology 12(6):378-90, 2007.
18. Tóth, T., Deák, L., Fazakas, F., Zheng, J., Muszbek, L. and Sziklai, I. A new mutation in the human pres gene and its effect on prestin function. International Journal of Molecular medicine, 20:545-550, 2007.
19. Anderson CT., Zheng J., Isolation of outer hair cells from the cochlear sensory epithelium in whole-mount preparation using laser capture microdissection. J Neurosci Methods, 162: 229-236, 2007.
20. Dallos P, Zheng J, Cheatham MA., “Prestin and the cochlear amplifier.” J Physiol., 1;576 (Pt 1):37-42, 2006.
21. He, D.Z.Z., Zheng, J., Kalinec, F., Kakehata, S., Santos-Sacchi J., Tuning in to the amazing outer hair cell: membrane wizardry with a twist and shout. J. Membrane Biol., 209: 119-34,2006.
22. Zheng J, Du GG, Anderson CT, Keller JP, Orem A, Dallos P, Cheatham M.“Analysis of the oligomeric structure of the motor protein prestin.” J Biol Chem., 281(29):19916-24., 2006