Dr. Rujun
Gong
Division of
Kidney Disease and Hypertension, School of Medicine
Brown University,
USA
Associate
Professor
Email: Rujun_Gong@Brown.edu, RGong@Lifespan.org
Qualifications
2001 Ph.D., Nanjing University School
of Medicine, China, Renal Physiology
1999 M.D., Nanjing University School of Medicine, China, Clinical Medicine
Publications
-
Andrew Brem,
David Morris, Rujun Gong*. Aldosterone induced fibrosis in the kidney:
Questions and controversies. American Journal of Kidney Disease 58(3):471-479,
2011.
-
Yan Ge, Jin Si,
Li Tian, Shougang Zhuang, Lance Dworkin, Rujun Gong*. Conditional ablation
of glycogen synthase kinase 3b in postnatal mouse kidney. Laboratory
Investigation 91(1):85-96, 2011.
-
Murugavel
Ponnusamy, Na Liu, Rujun Gong, Haidong Yan, Shougang Zhuang. ERK pathway
mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed
to necrotic renal epithelial cells. American Journal of Physiology Renal
Physiology 301(3):F650-9, 2011.
-
Murugavel
Ponnusamy, Li Ma, Rujun Gong, Pang M, Chin YE, Shougang Zhuang. P2X7
receptors mediate deleterious renal epithelial-fibroblast cross talk. American
Journal of Physiology Renal Physiology 300(1):F62-70., 2011.
-
Junming Luo,
Yingxin Li, Rujun Gong*. The mechanism of atopic march may be the social
event of cells and molecules. [Review] Journal of International Molecular
Medicine 26(12):779-785, 2010.
-
Maoyin Pang, Li
Ma, Rujun Gong, Tolbert E, Mao H, Ponnusamy M, Chin YE, Haidong Yan, Lance
Dworkin, Shougang Zhuang. A novel STAT3 inhibitor, S3I-201, attenuates renal
interstitial fibroblast activation and interstitial fibrosis in obstructive
nephropathy. Kidney International 78(3):257-268, 2010.
-
Andrew S. Brem, David
J. Morris, Yan Ge, Lance Dworkin, Evelyn Tolbert, Rujun Gong*. Direct
fibrogenic effects of aldosterone on -HSD activity.bnormotensive kidney: An
effect modified by 11 American Journal of Physiology Renal Physiology 298(5):
F1178-F1187, 2010.
-
Jin Si, Yan Ge,
Shougang Zhuang, Rujun Gong*. Inhibiting nonmuscle myosin II
impedes inflammatory infiltration and ameliorates progressive renal
disease. Laboratory Investigation 90(3): 448-458, 2010.
-
Featured article
with commentary: Putting the brakes on inflammatory cell motility. Laboratory
Investigation 90(3): 346-347, 2010.
-
Ponnusamy M,
Maoyin Pang, Annamaraju PK, Zhu Zhang, Rujun Gong, Y. Eugene Chin,
Shougang Zhuang. Transglutaminase-1 protects renal epithelial cells from
hydrogen peroxide-induced apoptosis through activation of STAT3 and Akt
signaling pathways. American Journal of Physiology Renal Physiology 297(5):F1361-70,
2009.
-
Zhu Zhang,
Jingping Xing, Li Ma, Rujun Gong, Y. Eugene Chin, Shougang Zhuang.
Transglutaminase-1 regulates renal epithelial cell proliferation through
activation of Stat-3. Journal of Biological Chemistry 284(5):3345-3353,
2009.
-
Rujun Gong*.
Multi-target anti-inflammatory action of hepatocyte growth factor. [Invited
Review] Current Opinion in Investigational Drugs 9(11):1163-1170,
2008.
-
Rujun Gong, Syed
Latif, David J. Morris, Andrew S. Brem. Co-localization of glucocorticoid
metabolizing and prostaglandin synthesizing enzymes in rat kidney and liver. Life
Sciences 83(21-22):725-731, 2008.
-
Shan Chen, Yan
Ge, Jin Si, Abdalla Rifai, Lance D. Dworkin, Rujun Gong*. Candesartan
suppresses chronic renal inflammation via a novel antioxidant action
independent of AT1R blockade. Kidney International 74(9):1128-1138,
2008.
-
Rujun Gong*, Yan
Ge, Shan Chen, Elizabeth Liang, Alfredo Esparza, Edmont Sabo, Agelito Yango,
Regional Gohh, Abdalla Rifai, Lance D. Dworkin. Glycogen synthase kinase 3b: a
novel marker and modulator of inflammatory injury in chronic renal allograft
disease. American Journal of Transplantation 8(9):1852-1863, 2008.
-
Rujun Gong*,
Abdalla Rifai, Yan Ge, Shan Chen, Lance D. Dworkin. Hepatocyte growth factor
suppresses proinflammatory NF-kB activation through GSK3b inactivation in renal
tubular epithelial cells. Journal of Biological Chemistry 283(12):7401-7410,
2008.
-
Rujun Gong,
David J. Morris, Andrew A. Brem. Variable Expression of 11ß Hydroxysteroid
Dehydrogenase (11b-HSD) Isoforms in Vascular Endothelial Cells. Steroids 73(11):1187-1196,
2008.
-
Rujun Gong,
David J. Morris, Andrew S. Brem. Human renal 11beta-hydroxysteroid
dehydrogenase 1 functions and co-localizes with COX-2. Life Sciences 82(11-12):631-637,
2008.
-
Rujun Gong,
Zhihong Liu, Leishi Li. Epistatic effect of plasminogen activator inhibitor 1
and b-fibrinogen genes on risk of glomerular microthrombosis in lupus
nephritis: Interaction with environmental/clinical factors. Arthritis and
Rheumatism57(5):1608-1617, 2007.
-
Chen Yu, Rujun
Gong, Abdalla Rifai, Evelyn M. Tolbert, Lance D. Dworkin. Long-term,
high-dosage candesartan suppresses inflammation and injury in chronic kidney
disease: nonhemodynamic renal protection. Journal of the American Society of
Nephrology 18(3):750-759, 2007.
Profile
Details
directly: http://www.Brown.edu/Research/Gong_Lab