Prof. Gabriele Nicolini

International & Late Phase Studies for Chiesi Farmaceutici, Italy




2009 Ph.D., University of Parma, Italy

1997 B.Sc., University of Milan, Italy

Publications (selected)

  1. M.Profita, R Gagliardo, R. Di Giorgi, F. Pompeo, M. Gjomarkaj, G. Nicolini, J. Bousquet, A. M. Vignola ; Biochemical interactions between beclomethasone, salbutamol or formoterol in sputum cells of mild to moderate asthmatics. Allergy 2005: 60: 323–329
  2. Papi A, Paggiaro P, Nicolini G, Vignola AM and Fabbri LM Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma. European Respiratory Journal 2007; 29: 682-689
  3. A.Papi, G.W. Canonica, P. Maestrelli, P. Paggiaro, D. Olivieri, E. Pozzi, N. Crimi, A.M. Vignola, P. Morelli, G. Nicolini and L.M. Fabbri, for the BEST Study Group Rescue Use of Beclomethasone and Albuterol in a Single Inhaler for Mild Asthma.N Engl J Med 2007;356:2040-52.
  4. Papi A, Paggiaro PL, Nicolini G, Vignola AM, Fabbri LM .Beclomethasone/formoterol versus fluticasone/salmeterol inhaled combination in moderate to severe asthma.Allergy 2007: 62: 1182–1188
  5. Descalzi D, Folli C, Nicolini G, Riccio AM, Gamalero C, Scordamaglia F, Canonica GW.Anti-proliferative and anti-remodelling effect of beclomethasonedipropionate, formoterol and salbutamol alone or in combination in primary human bronchial fibroblasts. Allergy. 2008 Apr;63(4):432-7.
  6. Fabbri LM, Nicolini G, Olivieri D, Papi A. Inhaled beclometasonedipropionate/formoterol extra-fine fixed combination in the treatment of asthma: evidence and future perspectives.Expert OpinPharmacother. 2008 Feb;9(3):479-90. Review
  7. Pierluigi Paggiaro, Gabriele Nicolini and Alberto Papi.Extrafinebeclomethasonedipropionate/formoterolhydrofluoroalkane-propelled inhaler in asthma. Expert Rev. Resp. Med. 2(2), 161–166 (2008)
  8. Gabriele Nicolini, Nicola Scichilone, Andrea Bizzi, Alberto Papi, Leonardo M Fabbri.Beclomethasone/formoterol fi xed combination for the management of asthma: patient considerations. Therapeutics and Clinical Risk Management 2008:4(5) 1–11
  9. Inhaled steroid/tobacco smoke particle interactions: a new light on steroid resistance.Invernizzi G, Ruprecht A, De Marco C, Mazza R, Nicolini G, Boffi R.Respir Res. 2009 Jun 11;10:48.
  10. A. Papi, G. Nicolini, E. Baraldi, A. L. Boner, R. Cutrera, G. A. Rossi, L. M. Fabbri. Regular vs prnnebulized treatment in wheezepreschoolchildren. Allergy 2009: 64: 1463–1471
  11. Zanini A, Chetta A, Saetta M, Baraldo S, Castagnetti C, Nicolini G, Neri M, Olivieri D.Bronchialvascularremodelling in COPD patients and its relationship with inhaled steroid treatment. Thorax 2009 64: 1019-1024
  12. Nicolini G, Cremonesi G, Melani AS.Inhaled corticosteroid therapy with nebulized beclometasonedipropionate. PulmPharmacolTher. 2010 Jun;23(3):145-55
  13. Scichilone N, Battaglia S, Sorino C, Paglino G, Martino L, Paternò A, Santagata R, Spatafora M, Nicolini G, Bellia V. Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma.Allergy. 2010 Jul;65(7):897-902
  14. Nicolini G, Chetta A, Simonazzi A, Tzani P, Aiello M, Olivieri D. Bothbronchial and alveolarexhalednitricoxide are reduced with extrafine beclomethasonedipropionate in asthma. AllergyAsthmaProc. 2010 Sep;31(5):85-90.
  15. Müller V, Gálffy G, Eszes N, Losonczy G, Bizzi A, Nicolini G, Chrystyn H, Tamási L. Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation. BMC Pulm Med. 2011 Jul 15;11:40
  16. Allegra L, Cremonesi G, Girbino G, Ingrassia E, Marsico S, Nicolini G, Terzano C; On behalf of the PRISMA (PRospectIve Study on asthMA control) Study Group. Real-life prospective study on asthma control in Italy: Cross-sectional phase results. Respir Med. 2012 Feb; 106(2): 205-214.
  17. Tzani P, Crisafulli E, Nicolini G, Aiello M, Chetta A, Clini EM, Olivieri D. Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients. Int J Chron Obstruct Pulmon Dis. 2011;6:503-9
  18. Peter J. Barnes, Gabriele Nicolini, Andrea Bizzi, Monica Spinola, and DaveSingh.Do inhaled corticosteroid/long-acting beta2-agonist fixed combinations provide superior clinical benefits compared with separate inhalers? A literature reappraisal.AllergyAsthmaProc. 2012 Mar;33(2):140-4
  19. Davide Paleari, Giovanni A Rossi, Gabriele Nicolini, Dario Olivieri.Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood.Expert Opinion on DrugDiscovery,Nov 2011, Vol. 6, No. 11: 1203-1214
  20. Alberto Papi, Gabriele Nicolini, Nunzio Crimi, Leonardo M Fabbri, Dario Olivieri, Andrea Rossi and Pierluigi Paggiaro.Step-down from high dose fixed combination therapy in asthma patients: a randomized controlled trial.RespiratoryResearch 2012, 13(1):54
  21. Claudio Terzano, Giovanni Cremonesi, Giuseppe Girbino, Eleonora Ingrassia, Serafino Marsico, Gabriele Nicolini and Luigi Allegra.1-year prospective real life monitoring of asthma control and quality of life in Italy.RespiratoryResearch 2012 Dec 6;13:112.
  22. Roberta Pisi, PanagiotaTzani, Marina Aiello, Enrico Martinelli, Emilio Marangio, Gabriele Nicolini, Dario Olivieri, and Alfredo Chetta.Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values. Allergy Asthma Proc 2013 Jan;34(1):14-20.
  23. Braido F, Brusselle G, Ingrassia E, Nicolini G, Price D, Roche N, Soriano JB, Worth H; LIAISON study group. InternationaLcross-sectIonAl and longItudinal assessment on aSthmacONtrol in European adult patients--the LIAISON study protocol. BMC Pulm Med. 2013 Mar 25;13:18
  24. de Marco R, Pesce G, Marcon A, Accordini S, Antonicelli L, Bugiani M, Casali L, Ferrari M, Nicolini G, Panico MG, Pirina P, Zanolin ME, Cerveri I, Verlato G. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PLoS One. 2013 May 10;8(5):e62985.
  25. Paggiaro P, Patel S, Nicolini G, Pradelli L, Zaniolo O, Papi A. Stepping down from high dose fluticasone/salmeterol to extrafine BDP/F in asthma is cost-effective. Respir Med. 2013, Oct;107(10):1531-7.
  26. Montalbano AM, Anzalone G, Albano GD, Sano CD, Gagliardo R, Bonanno A, Riccobono L, Nicolini G, Ingrassia E, Gjomarkaj M, Profita M. Beclomethasonedipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.

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