Dr. Honglian Shi

Department of Pharmacology & Toxicology

University of Kansas, USA



1995 Ph.D., Biophysics, Institute of Biophysics, Chinese Academy of Sciences
1993 M.Sc., Biophysics, Institute of Biophysics, Chinese Academy of Sciences
1990 B.Sc., Chemistry, Huazhong University of Science and Technology

Publications (Selected)

  1. Shi H, Noguchi N, and Niki E. Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol and alpha-tocopherol.Free Radic Biol Med 27:334-346; 1999.
  2. Shi H, Noguchi N, Xu Y, and Niki E. Formation of phospholipid hydroperoxides and its inhibition of alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite.Biochem Biophys Res Commun257:651-656; 1999.
  3. Shi H, Noguchi N, Xu Y, and Niki E. 1-Methyl-4- phenyl-2, 3-dihydro-pyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenyl- pyridinium. FEBS Lett461:196-200; 1999.
  4. Miyauchi K, Urakami T, Abeta H, Shi H, Noguchi N, and Niki E. Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution.Antioxidants & Redox Signaling1: 547-554; 1999.
  5. Noguchi N, Watanabe A, and Shi H. Diverse functions of antioxidants.Free Radic Res33:809-817; 2000.
  6. Shi H, Noguchi N, and Niki E. Galvinoxyl method for standardizing electron and proton donation activity.Methods in Enzymology 335:155-166; 2001.
  7. Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Attention to relative response across sequential electrodes improves quantitation of coulometric array. Anal Biochem 302:239-245; 2002.
  8. Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS.Characterization of diet-dependent metabolic serotypes: proof of principle in female and male rats.J Nutrition 132: 1031-1038; 2002.
  9. Shi H, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Characterization of diet-dependent metabolic serotypes: primary validation of male and female serotypes in independent cohorts of rats.J Nutrition132: 1039-1046; 2002.
  10. Burdick AD, Davis JW II, Liu KJ, Hudson LG, Shi H, Monske ML, and Burchiel SW. Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in MCF-10A cells.Cancer Res63: 7825-7833; 2003.
  11. Liu S, Shi H, Liu W, Furuichi T, Timmins G, and Liu K.Interstitial pO2in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats.J Cerebr Blood Flow Metab24: 343-349; 2004.
  12. Liu W, Rosenburg GA, Shi H, Furuichi T, Timmins G, Cunningham LA, and Liu KJ. Xanthine oxidase activates gelatinase A (MMP-2) in cultured rat vascular smooth muscle cells through proteolytic activities.Arch Biochem Biophys426: 11–17; 2004.
  13. Shi H, Hudson LG, Ding W, Wang S, Cooper KL, Liu S, Shi X, and Liu KJ.  Free radical generation and DNA damage by arsenite in keratinocytes. Chem Res Toxicol17: 871-878; 2004.
  14. Liu S, Timmins G, Shi H, Gasparovic CM, and Liu KJ. Application ofin vivoEPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress. NMR in Biomedicine17:327–334; 2004.
  15. Shi H, Paolucci U, Vigneau-Callahan KE, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: practical issues in development of expert system-based classification models in metabolomic studies. OMICS J Integr Biol8 (3): 197-208; 2004.
  16. Paolucci U, Vigneau-Callahan KE, Shi H, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: concerns and approaches for cohort and gender issues in serum metabolome studies. OMICS J Integr Biol8 (3): 209-220; 2004.
  17. Paolucci U, Vigneau-Callahan KE, Shi H, Shestopalov AI, Milbury PE, Matson WR, and Kristal BS. Development of biomarkers based on diet-dependent metabolic serotypes: characteristics of component-based models of metabolic serotypes.OMICS J Integr Biol8 (3): 221-238; 2004.
  18. Furuichi T, Liu W, Shi H, Miyake M, and Liu K. Generation ofhydrogen peroxide during brief oxygen-glucose deprivation induces preconditioning neuronal protection in primary cultured neurons. J Neurosci Res79 (6):816 – 824; 2005.
  19. Liu Z, Lu H, Shi H, Du Y, Yu J,Gu S, Chen X, Liu K, and Hu C. PUMA Overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells.Cancer Res65(5): 1647-54; 2005.
  20. Shi H, Timmins G, Monske1 M, Burdick A, Kalyararaman B, Liu Y, Clément J, Burchiel S, and Liu J. Evaluation of spin trapping agents and trapping conditions for detection of cell-generated superoxide.Arch Biochem Biophys437(1):59-68; 2005.
  21. Shi H, Liu S, Miyake M, and Liu K. Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.Chem Res Toxicol19: 655-660; 2006.
  22. Miyake M, Shen J, Liu S, Shi H, Liu W, Yuan Z, Pritchard A, Kao J, Liu K, and Rosen GM. Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2levels in mouse brain: A pharmacokinetic and pharmacodynamic study.J Pharmacol Exp Ther318:1187-1193; 2006.
  23. Shi H, and Liu K. Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia. Neurosci Lett410: 57-61; 2006.
  24. Ju W, Wang X, Shi H,Belinsky SA, and Lin Y. A critical role of luteolin-inducedreactive oxygen species in blockage of tumor necrosis factor-activatednuclear factor-kB pathway and sensitization of apoptosis in lung cancer cells.Mol Pharmacol71:1381-1388; 2007.
  25. Guo S, Wharton W, Moseley P, and Shi H. Overexpression of heat shock protein 70 reduces cell injury induced by oxygen and glucose deprivation through enhancing cellular reducing capacity. Cell Stress Chaper12(3):245-254; 2007.
  26. Guo S, Bragina O, Cao Z, Xu Y, Chen H, Jiang BH, Lin Y, Liu K, and Shi H. Glucose upregulates HIF-1α expression in primary cultured cortical neurons in response to hypoxia.J Neurochem105(5):1849-1860; 2008.
  27. Chen H, andShi H.A reducing environment stabilizes HIF-2α in SH-SY5Y cells under hypoxic conditions. FEBS lett582: 3899-3902; 2008. (PMCID: PMC2586911)
  28. Guo S, Miyake M, Liu K, and Shi H.Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced byin vitroischemia through deteriorating cellular redox environment.J Neurochem108(5):1309-1321; 2009. (PMCID: PMC2666308)
  29. Bragin DE, Zhou B, Ramamoorthy P, Müller WS, Connor JA, and Shi H. Differential changes of glutathione levels in astrocytes and neuronsin ischemic brains by two-photon imaging.J Cerebr Blood Flow Metab30(4):734-738; 2010. (PMCID: PMC2848708)
  30. Bao L, and Shi H. Arsenite induces endothelial cell permeability increase through a ROS-VEGF pathway.Chem Res Toxicol23(11): 1726-1734; 2010.
  31. (Featured in Chemical and Engineering News,October 27, 2010 DOI:10.1021/CEN102610120918)
  32. Yan J, Zhang Z, and Shi H. HIF-1 is involved in hyperglycemia-induced paracellular permeability of brain endothelial cells. Cell Mol Life Sci.
  33. Graham S, Gorin Y, Abboud H, Ding M, Lee DY, Shi H, Ding Y, Pulse M, and Ma R. Diabetes down-regulates TRPC6 protein expression in glomerular mesangial cells via a ROS and PKC Pathway.Am J Physiol Cell Physiol301:C304-C315, 2011.
  34. Zhang Z, Yan J, Chang YZ, SD Yan, and Shi H. Hypoxia inducible factor-1 for neurodegenerative diseases. Curr Med Chem. 18:4335-4343; 2011. PubMed#21861815.NIHMSID #329576.
  35. Ding H, Yan C, Shi H, Yu P, Zhao C, Chang SY, Zhao YS, Duan XL, and Chang YZ. Hepcidin is involved in the iron regulation in an ischemic brain.PLoS One6(9):e25324; 2011.
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