Dr. Nelson W. Chong
Department of Human and Health Sciences
University of Leicester, UK
Email: n.chong@westminster.ac.uk
Qualifications
Ph.D., Physiology, King’s
College
M.Sc., Pharmacology, King’s College
B.Sc., Biological Sciences, University of
Westminster
Publications (Selected)
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Ounzain S, Kobayashi
S, Peterson R, He Aibin, Samani NJ, Menick DR, Pu WT, Liang Q, Chong, N.W.
(2012) Cardiac
expression of STARS, a novel gene involved in cardiac development and
disease, is regulated by GATA4. Mol Cell Biol. 32,
1830-1843.
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Chong, N.W. Kokemoer, AL., Samani, N.J., Shin JT., Shaw, S. (2012)
STARS (Striated muscle Activator of Rho Signalling) is essential to
maintain cardiac development and functionin vivo viaa SRF pathway. PLoS One 7, e40966.
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Haque, R., Chong,
N.W., et al. (2011)
cAMP-dependent transcriptional regulation of the chicken arylalkylamine
N-acetyltransferase gene by novel regulatory elements of the proximal
promoter. J Neurochem 119, 6-17.
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Koekemoer, AL, Chong, NW et al (2009)
Myocyte stress 1 plays an important role in cellular hypertrophy and
protection against apoptosis. FEBS Lett. 583, 2964-2967.
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Ounzain, S., Dacwag, C.S., Samani, N.J.,
Imbalzano, A.N. and Chong, N.W. (2008) Comparative in silico analysis
identifies bona fide MyoD binding sites within the
Myocyte Stress 1 gene promoter. BMC Molecular Biology 9:50.
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Singletary, J.H., Chan, D., Samani,
N.J., and Chong, N.W. (2008) The canonical E-box motif: a target for
glucocorticoid action that drives rhythmic mouse Pai-1 transcription in
vitro. Gene 420, 42-47.
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Chong, N.W., Codd, V., Chan, D. and
Samani, N. J. (2006) Circadian clock genes cause activation of the human
PAI-1 gene promoter with 4G/5G allelic preference. FEBS Lett. 580, 4469-4472.
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Hartman, S., Touchton, G., Wynn, J.,
Geng, T., Chong, N.W., and Smith, E. (2005) Characterization of expressed
sequence tags from Gallus gallus pineal gland cDNA
library. Comp Funct Genom., 6, 301 -306.
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Chong, N.W., Chaurasia, S.C., Haque, R.,
Klein, D.C. and Iuvone, P.M. (2003) Temporal-spatial Characterization of
Chicken Clock Genes: Circadian Expression in Retina, P ineal Gland and
Peripheral Tissues. J. Neurochem 85, 851 -860.
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Mahadeva, H., Brooks, G., Lodwick, D.,
Chong, N.W. and Samani, N.J. (2002) ms1, a novel stress-responsive,
musclespecific gene that is up-regulated in early stages of pressure
overload -induced left ventricular hypertrophy. FEBS Lett 521, 100-104.
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*Bailey, M.J., *Chong, N.W., Xiong, J.
and Cassone, V.M. (2002) Chickens' Cry2: molecular analysis of an avian
cryptochrome in retinal and pineal photoreceptors. FEBS Letts 513, 169
-174. *Contributed equally.
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Chong, N.W.S., Bernard, M. and Klein,
D.C. (2000) Characterization of the chicken serotonin N-acetyltransferase
gene: activation via clock gene heterodimer: E-box interaction. J. Biol.
Chem. 275, 32991 -32998.
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Iuvone, P.M., Chong, N.W.S., Bernard,
M., Brown, A.D., Thomas, K.B. and Klein, D.C. (2000) Melatonin
biosynthesis in chicken retina: regulation of tryptophan hydroxylase and
arylalkylamine N-acetyltransferase. Advances in Experimental Medicine and
Biology 460, 31 -42.
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Bernard, M., Guerlotte, J., Greve, P.,
Grechez-Cassiau, A., Iuvone, P.M., Zatz, M., Chong, N.W.S., Klein, D.C.
and Voisin, P. (1999) Melatonin synthesis pathway: circadian regulation of
the genes encoding the key enzymes in the chicken pineal gland and retina.
Reprod. Nutr. Dev., 39, 325-334.
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Chong, N.W.S., Klein, D.C. and P. M.
Iuvone. (1998) Circadian expression of tryptophan hydroxylase mRNA in the
chicken retina. Mol. Brain Res., 61, 243 -250.
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Akbar, M.T., Rattray, M., Chong, N.W.S.
& Meldrum, B.S. (1998) Reduction of GABA and glutamate transporter
messenger RNAs in the severe-seizure genetically epilepsy-prone rat,
Neuroscience, 85, 1235-1251.
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Chong, N.W.S., Cagampang, F.R.A.,
Campbell, I.C., Coen, C.W. and Powell, J.F. (1996) Rapid identification of
novel genes expressed in a circadian manner in rat suprachiasmatic nuclei,
NeuroReport 7, 1199 -1203.
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Cagampang, F.R.A., Rattray, M., Powell,
J.F., Chong, N.W.S., Campbell, I.C. and Coen, C.W. (1996) Circadian
variation of EAAC1 glutamate transporter mRNA in the rat suprachiasmati c
nucleus. Mol. Brain Res. 35, 190-196.
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Sugden, D., Chong, N.W.S., Lewis, D.
(1995) Structural Requirements at the Melatonin Receptor, Br. J.
Pharmacol. 114, 618-623.
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Chong, N.W.S. and Sugden, D. (1994)
Thermodynamic analysis of agonist and antagonist binding to the chicken
brain melatonin receptor, Br. J. Pharmacol., 111, 295 -301.
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Chong, N.W.S. & Sugden, D. (1993)
Antigonadal effects of two novel melatonin analogues in adult Djungarian
hamsters. J Pineal Res. 15, 104-107.
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Chong, N.W.S., Evans, J.E. & Sugden,
D. (1993) N-Bromoacetyl 5-methoxytryptamine: an irreversible melatonin
ligand? Biochem. Biophy. Res. Commun., 193, 1355 -1361.
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Chong, N.W.S. & Sugden, D. (1991)
Ontogeny of chick brain melatonin receptors. Neurosci. Lett., 138, 37 -40.
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Paterson, A., Chong, N.W.S., Brinklow,
B., Loudon, A.L., & Sugden, D. (1991) Characterization of 2-[125I] iodomelatonin binding sites in the brain of a marsupial, Bennett's
wallaby (Macropus rufogriseus rufogriseus). Comp.
Biochem. Physiol., 102A, 55 -58.
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Chong, N.W.S. & Sugden, D. (1991)
Guanine nucleotides regulate 2-[125I] iodomelatonin binding sites in chick
retinal pigment epithelium but not in neuronal retina. J. Neurochem., 57,
685 -689.
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Sugden, D. & Chong, N.W.S. (1991)
Pharmacological identity of 2-[125I] iodomelatonin binding sites in chicken
brain and sheep pars tuberalis, Brain Res., 539, 151 -154.
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Moore, P.K., al-Swayeh, O.A., Chong,
N.W.S., Evans, R.A. & Gibson, A. (1990) L-NG-nitroarginine (L-NOARG),
a novel, L-arginine-reversible inhibitor of endothelium-dependent
vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.